Results 131 to 140 of about 1,977,355 (211)
Critical realism as a fractal philosophy [PDF]
There are two overarching questions that guide this paper: What are some potential issues with the criterion for judgemental rationality as developed by Bhaskar?
Isaksen, Karl Robert
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Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
"Critical Realism and the Political Economy of the Euro" [PDF]
This paper is concerned with two issues. First, it discusses some of the main problems and inferences the methodological approach of critical realism raises for empirical work in economics, while considering an approach adopted to try to overcome these ...
Malcolm Sawyer +2 more
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Can van Fraassen's anti-realism give an account of novel predictions of unexpected phenomena? [PDF]
, 2011 In this paper it will be addressed the possibility of an account of novel predictions of unexpected phenomena by physical theories within van Fraassen's anti-realism.
Bacelar Valente, Mario
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Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Thinking About the Ultimate Argument for Realism [PDF]
, 2003 The aim of this paper is to rebut two major criticisms of the No-Miracles Argument for Realism. The first comes from Musgrave (1988). The second comes from Colin Howson (2000).
Psillos, Stathis
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ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy
Molecular Oncology, EarlyView.We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen +19 more
wiley +1 more source
, 2005 This paper first revisits the discussion between Tony Lawson and Sandra Harding in the journal Feminist Economics in light of the author’s own research into basic mechanisms of capitalist economies, research that has been influenced by feminist ...
Brown, G. +2 more
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