Results 221 to 230 of about 2,167,076 (286)

Niche‐Mediated Neural Priming Enables Robust and Scalable Generation of Human Choroid Plexus Organoids

Advanced Science, EarlyView.
Compared to E8, mTeSR1 culture downregulated WNT and TGF‑β signaling, and upregulated neural differentiation pathways, enhancing neural priming. Under skin organoid induction conditions, mTeSR1‑cultured hESCs generated organoids with significantly higher neuroepithelial differentiation.
Zhongliang Chen, Liangxia Jiang, Xianbin Wang, Lili Zhong, Rongcan Luo, Min Su, Liangzhao Chu, Peng Luo   +7 more
wiley   +1 more source

Automated right ventricle-to-left ventricle diameter ratio predicts ICU stay for acute pulmonary embolism on CTPA examinations in the emergency department. [PDF]

Cardiovasc Diagn Ther
Batra K, Xi Y, Anderson K, Shah T, Wiessman M, Govindu SR, Vajramani A, Peshock RM.   +7 more
europepmc   +1 more source

Nrsn1–Smarcc1 Coupling Regulates Neural Stem Cell Differentiation and Chronic‐phase Recovery After Ischemic Stroke

Advanced Science, EarlyView.
In the post‐stroke brain, Foxa2 induces the transcriptional upregulation of Nrsn1 in NSCs. Nrsn1 functionally couples with Smarcc1, modulating its nuclear availability and protein abundance, thereby influencing Smarcc1‐associated regulatory programs linked to neuronal lineage commitment. Through this coupling, Nrsn1 promotes the differentiation of NSCs
Ruolin Zhang, Chang Liu, Yuneng Zhou, Kaichen Zhao, Muyang Li, Bingcheng Cai, Ying Wang, Zhiyuan Yuan, Zhaoxin Liu, Zilong Yuan, Yao Xiao, Peiyang Zhou, Ke Shui, Wendai Bao, Min Zhang, Jun Qin, Jun Chen, Xin Yang, Zhiqiang Dong   +18 more
wiley   +1 more source

Double-Chambered Left Ventricle: How Cardiac Magnetic Resonance Overturned the Diagnosis. [PDF]

JACC Case Rep
Pomiato E, Cavaliere A, Bobbo M, Reffo E, Di Salvo G.   +4 more
europepmc   +1 more source

Mitochondria‐Targeted Multimodal Nanotherapeutics Suppress Oxidized mtDNA‐Driven Inflammation at the Source

Advanced Science, EarlyView.
Ox‐mtDNA fragments escaping from mitochondria drive robust inflammatory responses. A targeted nanoplatform simultaneously inhibits mitochondrial FEN1‐mediated mtDNA cleavage and scavenges ROS, preventing the generation of immunogenic Ox‐mtDNA fragments. The released SeNPs further promote autophagic clearance of cytosolic mtDNA. Consequently, cGAS‐STING,
Wen‐Ling Li, Juan Cao, Yu‐Lin Wang, Yu‐Han Fan, Jia‐Qi Xu, Xian Wu Cheng, Lei Xing, Hu‐Lin Jiang   +7 more
wiley   +1 more source

Impact of global work index on obesity paradox in heart failure with advanced left ventricle remodeling. [PDF]

Front Cardiovasc Med
Pan R, Tudi X, Jiang W, Zong X, Ni Y, Tao R, Fan Q.   +6 more
europepmc   +1 more source

Neuromorphic Deep‐Ultraviolet Signal Processing Using a‐Ga2O3

Advanced Electronic Materials, EarlyView.
Amorphous gallium oxide (a‐Ga2O3) metal‐semiconductor‐metal photodetectors exhibit paired‐pulse facilitation arising from charge trapping. Four‐bit UVC binary sequences are encoded into separable conductance states. An RC equivalent circuit model of the device is deployed in single‐ and composite multi‐node reservoir computers, achieving ∼95% accuracy ...
Sidhant Sharma, Arthur Robert, Florian Wilke, Martin W. Allen, Valentina Baccetti, Jim G. Partridge, Hiep N. Tran   +6 more
wiley   +1 more source

Surgical treatment of postinfarction thrombosed left ventricle aneurysm formed from coronary artery dissection. [PDF]

Am Heart J Plus
Gogayeva OK, Nudchenko OO, Rudenko ML, Rudenko AV.   +3 more
europepmc   +1 more source

Chinese Expert Consensus on the Clinical Application of Finerenone in Geriatric Comorbidities

AGING MEDICINE, EarlyView.
Mineralocorticoid receptor (MR) overactivation drives inflammation, oxidative stress, and fibrosis in the heart, kidneys, and vasculature, leading to cardiorenal dysfunction. MR signaling promotes hypertrophy, remodeling, and injury through pathways like oxidative stress and inflammation, resulting in vascular stiffness and progressive organ damage ...
Xiaoming Wang, Cuntai Zhang
wiley   +1 more source