British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Ventricular fibrillation (VF) in coronary heart disease accounts for up to 70% of sudden cardiac death. We examined whether diltiazem N‐oxide (DNO) has ischaemia‐selective antiarrhythmic activity. Experimental Approach Randomised and blinded experiments were performed in rat isolated hearts and in anaesthetised rats to ...
Louise M. Hesketh +5 more
wiley +1 more source
Correlation Between Estimated Glomerular Filtration Rate and Asymptomatic Left Ventricular Diastolic Dysfunction in Patients With Type 2 Diabetes Mellitus. [PDF]
AACE Endocrinol DiabetesLiu Y +6 more
europepmc +1 more source
Physiological Basis of Sex Differences in Human Performance and Exercise‐Associated Pathology
Clinical Endocrinology, EarlyView.ABSTRACT The presence of sex differences in human physical performance is well‐established and shaped by distinct endocrine, anatomical and physiological mechanisms. Despite sustained advances, our understanding of how inherent biological factors drive variations in exercise capacity and related pathologies is still developing.
David A. Holdsworth +7 more
wiley +1 more source
Metabolic syndrome, left ventricular diastolic dysfunction and heart failure with preserved ejective fraction. [PDF]
Front Endocrinol (Lausanne)Zhou D +7 more
europepmc +1 more source
Obesity in Classic Congenital Adrenal Hyperplasia: Mechanisms, Complications and Management
Clinical Endocrinology, EarlyView.ABSTRACT Classic congenital adrenal hyperplasia (CCAH) is an autosomal recessive genetic disorder primarily caused by 21‐hydroxylase deficiency. Although the survival rate of patients has significantly improved with glucocorticoid replacement therapy, long‐term use of supraphysiological doses and multiple factors inherent to the disease itself have led
Jialin Mu +5 more
wiley +1 more source
Iconoclasts topple adaptive myocardial hypertrophy in aortic stenosis
, 2005 Paulus, W.J.S., Buermans, H.P.J.
core +1 more source
4D flow MRI-based grading of left ventricular diastolic dysfunction: a validation study against echocardiography. [PDF]
Eur RadiolReiter C +6 more
europepmc +1 more source
Prediabetes, Malignant Ventricular Hypertrophy and Stroke: The SPRINT Trial
Diabetes, Obesity and Metabolism, EarlyView.ABSTRACT Aims Prediabetes and left ventricular hypertrophy (LVH) are common risk factors in adults with hypertension. Whether their coexistence, particularly in the presence of subclinical myocardial injury or stress (malignant LVH), confers a heightened stroke risk is unknown.
Arnaud D. Kaze +7 more
wiley +1 more source
Left ventricular diastolic dysfunction in non-myocardial disorders. [PDF]
Eur Heart J Cardiovasc ImagingSmiseth OA +3 more
europepmc +1 more source
GIP in Cardiovascular and Kidney Disease: From Physiology to Pharmacology
Diabetes, Obesity and Metabolism, EarlyView.ABSTRACT Aims To provide a comprehensive overview of the cardiovascular and renal effects of glucose‐dependent insulinotropic polypeptide (GIP) by integrating its physiological role with recent human trial data on tirzepatide, the first dual GIP and glucagon‐like peptide‐1 (GLP‐1) receptor agonist.
Michelantonio De Fano +4 more
wiley +1 more source