Terapêutica de Ressincronização Cardíaca e Efeito Pró-Arrítmico: um Problema que Deve Ser Lembrado [PDF]
, 2014 The demonstrated benefits of cardiac resynchronization therapy (CRT) in reducing mortality and hospitalizations for heart failure, improving NYHA functional class and inducing reverse remodeling have led to its increasing use in clinical practice ...
Branco, LM +8 more
core +1 more source
Advanced Science, EarlyView.Pulmonary hypertension (PH) is a progressive condition with high morbidity and mortality, largely owing to right ventricular (RV) failure resulting from maladaptive remodeling. Our study provides strong evidence in support of a critical, detrimental role for AXL as a previously unrecognized determinant driving RV fibrotic pathology in PH.
Li‐Wei Wu +17 more
wiley +1 more source
Revascularization in Severe Left Ventricular Dysfunction
Journal of the American College of Cardiology, 2015 The highest-risk patients with heart failure with reduced ejection fraction are those with ischemic cardiomyopathy and severe left ventricular systolic dysfunction (ejection fraction≤35%). The cornerstone of treatment is guideline-driven medical therapy for all patients and implantable device therapy for appropriately selected patients.
Velazquez, Eric J., Bonow, Robert O.
openaire +2 more sources
Advanced Science, EarlyView.Lipid droplets (LDs) protect the heart against lipotoxicity in cardiac ischemia/reperfusion (I/R) injury; however, they are insufficient to prevent cardiomyocyte death. Seipin plays a central role in the insufficient formation of LDs, subsequent lipotoxicity, and myocardial injury during cardiac I/R injury.
Changyun Liu +13 more
wiley +1 more source
Exercise echocardiography predicts development of left ventricular dysfunction in medically and surgically treated patients with asymptomatic severe aortic regurgitation [PDF]
, 2000 S. Wahi +5 more
openalex +1 more source
Off-pump coronary artery bypass grafting is safe and effective in patients with severe left ventricular dysfunction [PDF]
, 2021 Mateo Marín-Cuartas +6 more
openalex +1 more source
Advanced Science, EarlyView.In Yoo and Mainkar et al., we present a minimally invasive, CM‐selective modRNA delivery system encapsulated in lipid nanoparticles for intravenous (IV) administration. This platform enables selective cardiac translation of therapeutic modRNA but suppresses expression in off‐target tissues, including tumors.
Jimeen Yoo +19 more
wiley +1 more source
Fenofibrate prevents isoproterenol-induced left ventricular hypertrophy and pump dysfunction in rats [PDF]
, 2011 MSc (Med), University of the Witwatersrand, Faculty of Health Sciences, School of PhysiologyThe role of metabolic remodelling in heart failure is not fully understood, significant evidence has accumulated to suggest that it may be central to the ...
Maswanganyi, Tlangelani
core
Left ventricular systolic dysfunction after acute myocardial infarction is associated with a high symptom burden and worse secondary prevention [PDF]
, 2023 Elisha J. Hamilton +8 more
openalex +1 more source
Temporal Transcriptional Regulation of Human Neuronal Differentiation via Forward Programming
Advanced Science, EarlyView.Single‐cell profiling of TF‐induced forward programming versus stepwise dual‐SMAD differentiation reveals that divergent trajectories set the pace of neurogenesis. OLIG TFs advance cell‐cycle exit via NOTCH modulation, while NEUROD2 later accelerates maturation. The study elucidates transcriptional mechanisms governing differentiation timing, providing
Lingling Zhu +13 more
wiley +1 more source