Results 71 to 80 of about 2,930,669 (250)

Overweight and obesity impair left ventricular systolic function as measured by left ventricular ejection fraction and global longitudinal strain

Cardiovascular Diabetology, 2018
Aims Obesity is associated with type 2 diabetes mellitus, left ventricular diastolic dysfunction and heart failure but it is unclear to which extent it is related to left ventricular systolic dysfunction.
Peter Blomstrand, Peter Sjöblom, Mats Nilsson, Magnus Wijkman, Martin Engvall, Toste Länne, Fredrik H. Nyström, Carl Johan Östgren, Jan Engvall   +8 more
doaj   +1 more source

Prognostic impacts of changes in left ventricular ejection fraction in heart failure patients with preserved left ventricular ejection fraction

Open Heart, 2020
BackgroundIt has been reported that recovery of left ventricular ejection fraction (LVEF) is associated with better prognosis in heart failure (HF) patients with reduced EF (rEF).
Tetsuro Yokokawa, Akiomi Yoshihisa, Yu Sato, Yuki Kanno, Mai Takiguchi, Satoshi Abe, Tomofumi Misaka, Takamasa Sato, Masayoshi Oikawa, Atsushi Kobayashi, Takayoshi Yamaki, Hiroyuki Kunii, Yasuchika Takeishi   +12 more
doaj   +1 more source

Chinese Expert Consensus on the Clinical Application of Finerenone in Geriatric Comorbidities

AGING MEDICINE, EarlyView.
Mineralocorticoid receptor (MR) overactivation drives inflammation, oxidative stress, and fibrosis in the heart, kidneys, and vasculature, leading to cardiorenal dysfunction. MR signaling promotes hypertrophy, remodeling, and injury through pathways like oxidative stress and inflammation, resulting in vascular stiffness and progressive organ damage ...
Xiaoming Wang, Cuntai Zhang
wiley   +1 more source

Towards Phenotyping Characteristics and Mechanism of Conduction Delay in Patients With Nonischemic Heart Failure With Reduced Ejection Fraction: Insights From Cardiac Magnetic Resonance Imaging

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Considering that 30% to 40% of patients do not benefit from cardiac resynchronization therapy implantation, it is insufficient to evaluate patients with heart failure with reduced ejection fraction solely based on QRS duration and morphology ...
Di Zhou, Mengdi Jiang, Leyi Zhu, Huaying Zhang, Weichun Wu, Jing Xu, Wenjing Yang, Yining Wang, Xinqiao Lian, Wenli Zhou, Tingting Zheng, Arlene Sirajuddin, Andrew E. Arai, Xiaohan Fan, Shihua Zhao, Minjie Lu   +15 more
doaj   +1 more source

Refining a preclinical model of viral myocarditis in accordance with biotech standards

Animal Models and Experimental Medicine, EarlyView.
This study aimed to refine a murine model of Coxsackievirus B3‐induced myocarditis by integrating dietary and imaging innovations to improve animal welfare, data quality, and clinical applicability. The refined diet significantly reduced animal health burden, reduced weight loss, and stabilized blood glucose during development of cardiac inflammation ...
Jonas Stewen, Julia Riedesel, Juliane Stein, Brandon H. Greene, Svenja Rohde, Sonja Suess, Bjoern Keiner, Priya Panjwani, Padmapriya Ponnuswamy, Juan E. Camacho Londoño   +9 more
wiley   +1 more source

Aortic valve disease: Novel animal models for advancing our understanding of the underlying mechanisms

Animal Models and Experimental Medicine, EarlyView.
Due to the complex pathophysiology of aortic valve disease (AVD) and the resulting lack of effective pharmacotherapy, existing animal models are valuable research tools, but each has its own strengths and limitations. This review systematically surveys the major AVD models, compares their induction methods, pathological features, advantages and ...
Liya Hou, Xue Liu, Wangxing Hu, Xianbao Liu, Wei Zhu   +4 more
wiley   +1 more source

Evidence regarding clinical use of microvolt T-wave alternans [Accuracy of microvolt T-wave alternans testing] [PDF]

, 2011
Background: Microvolt T-wave alternans (MTWA) testing in many studies has proven to be a highly accurate predictor of ventricular tachyarrhythmic events (VTEs) in patients with risk factors for sudden cardiac death (SCD) but without a prior history of ...
Hohnloser, Stefan H., Cohen, Richard J., Ikeda, Takanori   +2 more
core   +1 more source

Silk Fibroin for Cardiovascular Medical Devices: Review of Material Properties, Applications, and Clinical Potential

Advanced NanoBiomed Research, EarlyView.
Silk fibroin is an attractive natural biomaterial that can be engineered into diverse cardiovascular constructs, including vascular grafts, cardiac patches, heart valves, and stent coatings. Its tunable biological and mechanical properties have driven substantial preclinical progress; however, widespread clinical translation in cardiovascular ...
Mahsa Haghighattalab, Matt Govendir, Kristina Andelovic, Zachary Och, Fatemeh Karimi, Munira Xaymardan, Tomasz Jungst, Jelena Rnjak‐Kovacina, Nona Farbehi   +8 more
wiley   +1 more source

Heart Failure Treated with Low-dose Milrinone in a Full-term Newborn

Prague Medical Report, 2012
A term newborn with a hypocontractile myocardium complicating persistent pulmonary hypertension of the newborn was successfully treated with a low-dose phosphodiesterase III inhibitor milrinone.
S. Šebková, V. Tomek, P. Zemanová, Jan Janota   +3 more
doaj   +1 more source

SpartanAnatomy.org: Evaluating a new interactive neuroradiology tool for early medical education

Anatomical Sciences Education, EarlyView.
Abstract Teaching neuroanatomy through the lens of magnetic resonance imaging (MRI) offers medical students a strong foundation for success. However, many existing MRI learning resources lack interactivity and user‐friendliness, require payment, or include an overwhelming number of labeled structures.
Halie Kerver, Cody Lee, Danielle Keller, Ruxin Shi   +3 more
wiley   +1 more source