Results 241 to 250 of about 555,285 (355)

Curved Bistable Origami‐Inspired Flexible Transcatheter Mitral Valve Clamping

Advanced Science, EarlyView.
A lightweight bistable curved origami dilator combines reversible deformation and high stability, offering a promising solution for minimally invasive mitral valve repair. Abstract Curved origami exhibits remarkable potential for minimally invasive medical applications owing to its unique geometric programmability and mechanical tunability. Building on
Siyu Gao, Fan Jiang, Xiuting Sun, Peng Qi, Jian Xu   +4 more
wiley   +1 more source

Latent Cytomegalovirus Infection Is Associated With Impaired Left Ventricular Function After ST-Segment-Elevation Myocardial Infarction. [PDF]

J Am Heart Assoc
Spray L, McIntosh A, McCartney PJ, Macfarlane PW, Maznyczka A, Welsh P, Berry C, Spyridopoulos I.   +7 more
europepmc   +1 more source

Colchicine Improves Survival, Left Ventricular Remodeling, and Chronic Cardiac Function After Acute Myocardial Infarction

, 2017
Koichiro Fujisue, Koichi Sugamura, Hirofumi Kurokawa, Junichi Matsubara, Masanobu Ishii, Yasuhiro Izumiya, Koichi Kaikita, Seigo Sugiyama   +7 more
openalex   +2 more sources

AXL Promotes Ischemic Myelin Repair Through Alleviating Myelin Debris Deposition and Lipid Droplets Accumulation

Advanced Science, EarlyView.
Microglial AXL drives white matter repair after stroke by orchestrating the cleanup of myelin debris. Mechanistically, AXL signals through EGR1 to boost Smpd1 transcription, regulating sphingolipid metabolism and preventing lipid droplet toxicity. Restoring the pathway with ASM therapy mitigates damage, positioning AXL as a key node for therapeutic ...
Junqiu Jia, Yonghui Gan, Jia Li, Lilin Li, Hailan Meng, Min Sun, Lei Ye, Rui Mao, Xiang Cao, Shengnan Xia, Xinyu Bao, Renyuan Liu, Meijuan Zhang, Yun Xu   +13 more
wiley   +1 more source

Ultrasound Evaluation of Left Ventricular Function in Coronary Artery Ectasia: The Added Value of 2D Speckle-tracking Echocardiography. [PDF]

J Saudi Heart Assoc
Elshaer OA, Gomaa M, Elgamal RM, Fahmy MS, Dawoud RN, Biomy R, Ahmed AM, Salama MK.   +7 more
europepmc   +1 more source

Single‐Cell Mitochondrial Lineage Tracing Decodes Fate Decision and Spatial Clonal Architecture in Human Hematopoietic Organoids

Advanced Science, EarlyView.
This study repurposes mitochondrial DNA mutations as endogenous barcodes for lineage tracing in human pluripotent stem cell‐derived organoids. Integrated with transcriptomic and spatial data, it reveals NOTCH‐mediated stromal‐progenitor crosstalk orchestrates clonal dynamics and spatial zonation during early hematopoietic development, offering a non ...
Yan Xue, Junhao Su, Yiming Chao, Lu Liu, Xinyi Lin, Yang Xiang, Mun Kay Ho, Zezhuo Su, Junyi Chen, Zhuojuan Luo, Chengqi Lin, Ruibang Luo, Theo Aurich, Jianfeng Wu, Kelvin Sin Chi Cheung, Yuanhua Huang, Joshua W. K. Ho, Ryohichi Sugimura   +17 more
wiley   +1 more source

Leucine‐Dependent SLC7A5–PGAM5 Interaction Promotes Advanced Atherosclerosis Through Hindering Mitochondrial Function of Macrophages

Advanced Science, EarlyView.
Higher plasma leucine is associated with increased risk of new‐onset myocardial infarction. Leucine deprivation alleviates advanced atherosclerosis in mice. Tumor‐induced leucine deprivation reprograms macrophage metabolism and increases CD5Lhi macrophages in mouse plaques. Mechanistically, leucine deficiency reduced SLC7A5‐PGAM5 binding in macrophages,
Shan Zhong, Xueyu Wang, Qingsong Li, Siqi Wang, Bin Sun, Wenjun Ni, Gengyu Zhou, Fan Wang, Xianwei Xie, Cheng Jin, Gang Xu, Peng Zhao, Xiang Peng, Feiyuan Han, Xiangwen Xi, Yidan Wang, Juan Xu, Yue Wang, Xia Gu, Shuo Li, Jian Zhang, Shuijie Li, Jinwei Tian   +22 more
wiley   +1 more source

Evaluation of left ventricular function using various echocardiographic techniques in hypoxic neonates during therapeutic hypothermia and after rewarming. [PDF]

J Ultrason
Brunets N, Brunets V, Wójcik-Sęp A, Bokiniec R.   +3 more
europepmc   +1 more source

Phocaeicola coprophilus‐Derived 6‐Methyluracil Attenuates Radiation‐Induced Intestinal Fibrosis by Suppressing the IDO1‐Kynurenine‐AHR Axis

Advanced Science, EarlyView.
IR‐induced dysbiosis depletes P. coprophilus and its metabolite 6‐methyluracil, leading to disinhibition of the IDO1‐Kyn‐AHR axis. This results in sustained fibroblast activation and collagen deposition, driving radiation induced intestinal fibrosis. ABSTRACT Therapeutic options for radiation‐induced intestinal fibrosis (RIF) remain limited. This study
Jiaxin Zhang, Zhen Wang, Shuang Li, Chao Luo, Han Li, Shengjie Ma, Pai Wang, Heshi Liu, Lijun Sun, Yue Yin, Weizhen Zhang, Quan Wang   +11 more
wiley   +1 more source

Mortality After Non-ST-Segment Elevation Myocardial Infarction: Impact of Left Ventricular Function and Coronary Artery Disease. [PDF]

JACC Adv
Stødkilde-Jørgensen N, Olesen KK, Gyldenkerne C, Hansen MK, Nørgaard BL, Thim T, Nielsen RR, Maeng M.   +7 more
europepmc   +1 more source