Results 81 to 90 of about 585,525 (398)

Cardiomyocyte‐Enriched USP20 Ameliorates Pathological Cardiac Hypertrophy by Targeting STAT3 Deubiquitination

Advanced Science, EarlyView.
Cardiomyocyte‐enriched USP20 regulates the K63‐linked ubiquitination of STAT3, and the cardiomyocyte‐specific USP20‐STAT3‐CARM1 axis exerts a protective role in cardiac hypertrophy. Targeting USP20 through cardiac‐specific gene therapy presents a promising strategy for the treatment of cardiac hypertrophy.
Lingfeng Zhong, Shanshan Dai, Fan Yu, Guo‐Ping Shi, Qinyan Gong, Yucong Zhang, Jingsi Duan, Zhengyin Lou, Zhixuan Tang, Fuzhe Gong, Derong Chen, Liya Hou, Xinyang Hu, Jinghai Chen, Jian'an Wang, Deling Yin   +15 more
wiley   +1 more source

Leucine‐Rich Repeat‐Containing G Protein‐Coupled Receptor 6 Ameliorates Pressure Overload‐Induced Cardiac Hypertrophy by Regulating Cardiomyocyte Metabolic Reprogramming

Advanced Science, EarlyView.
LGR6 overexpression ameliorates cardiac hypertrophy by regulating metabolic reprogramming through USP4‐PPARα pathway. Abstract Metabolic reprogramming is a pivotal mechanism in the pathogenesis of pathological cardiac hypertrophy. Leucine‐rich repeat‐containing G protein‐coupled receptor 6 (Lgr6) has emerged as a significant player in cardiovascular ...
Mengmeng Zhao, Jianfang Liu, Shanshan Peng, Zihui Zheng, Siqi Liu, Jun Wan, Yao Xu, Menglong Wang   +7 more
wiley   +1 more source

An analysis of electrocardiographic criteria for determining left ventricular hypertrophy

Arquivos Brasileiros de Cardiologia, 2002
OBJECTIVE: To determine the most sensitive criterion for the detection of left ventricular hypertrophy according to echocardiographically defined left ventricular mass.
Carlos Alberto Gasperin, Helio Germiniani, Carlos Roberto Facin, Admar Moraes de Souza, Cláudio Leinig Pereira da Cunha   +4 more
doaj   +1 more source

Exploring the Influence of Parametrized Pulsatility on Left Ventricular Washout under LVAD Support: A Computational Study Using Reduced-Order Models [PDF]

arXiv, 2023
Medical therapy for patients with severe heart disease often relies on left ventricular assist devices (LVADs). It is an ongoing topic of research how complications like stagnation and thrombosis can be prevented by using artificial pulsatility. We study a parametric pulse profile and its effect on the left ventricular washout using a computational ...
arxiv  

Hyperaldosteronism and Left Ventricular Hypertrophy [PDF]

Hypertension, 2010
To the Editor: In their prospective study, Gaddam et al1 have examined the effects of spironolactone on cardiac structure in 34 patients with resistant hypertension who were separated according to their plasma aldosterone levels. At baseline, cardiac volume overload was detected in patients with higher aldosterone levels that was significantly and ...
SECHI, Leonardo Alberto, COLUSSI, Gian Luca, CATENA, Cristiana   +2 more
openaire   +2 more sources

Flavonifractor Plautii or Its Metabolite Desaminotyrosine as Prophylactic Agents for Alleviating Myocardial Ischemia/Reperfusion Injury

Advanced Science, EarlyView.
The gut microbiome is a potential target for treating cardiovascular disease. It is found that prophylactic administration of Flavonifractor plautii or its metabolite desaminotyrosine (DAT) exerts pleiotropic cardioprotective effects via promoting cardiomyocyte survival and attenuating cardiac inflammation against myocardial ischemia/reperfusion (I/R ...
Heng Du, Xu Liu, Jianghua Shen, Hailong Yuan, Hao Zhang, Gan Xi, Yujing Li, Yuhan Wang, Jiahe Zhang, Chaofan Yang, Pengfei Xu, Jiawan Wang, Fang Wang, Siqi Liu, Yanan Zhou, Qi Gu, Jingjing Lu, Tuo Wei, Zeyu Gao, Jingyi Zang, Jun Wang, Moshi Song   +21 more
wiley   +1 more source

Aortic calcification and femoral bone density are independently associated with left ventricular mass in patients with chronic kidney disease [PDF]

, 2012
Background Vascular calcification and reduced bone density are prevalent in chronic kidney disease and linked to increased cardiovascular risk. The mechanism is unknown.
Chue, Colin D., Crabtree, Nicola J., Edwards, Nicola C., Ferro, Charles J., Moody, William E., Steeds, Richard P., Townend, Jonathan N., Wall, Nadezhda A., Zehnder, Daniel   +8 more
core   +3 more sources

Fish Swim Bladder‐Derived ECM Hydrogels Effectively Treat Myocardial Ischemic Injury through Immunomodulation and Angiogenesis

Advanced Science, EarlyView.
A unique hydrogel based on extracellular matrix from fish swim bladder, which is suitable for transcatheter delivery and possesses remarkable reparative capabilities for treating heart failure, is developed. It emerges as a multi‐effect factor profoundly influencing inflammation regulation, angiogenesis, and myocardial metabolism.
Yulong Fu, Canran Gao, Hailing Zhang, Jing Liu, Boxuan Li, Wei Chen, Xiuping Chen, Xue Lin, Ligang Fang, Zhihong Wang   +9 more
wiley   +1 more source

Impaired Ca2+-handling in HIF-1α+/− mice as a consequence of pressure overload [PDF]

, 2009
The hypoxia-inducible factor (HIF)-1 is critically involved in the cellular adaptation to a decrease in oxygen availability. The influence of HIF-1α for the development of cardiac hypertrophy and cardiac function that occurs in response to sustained ...
A Robinson, A Siddiq, Adam G. Rokita, AK Neumann, Anke Zieseniss, AY Yu, D Tirziu, DM Katschinski, Dörthe M. Katschinski, G Kissling, G Loor, Gerhard Breves, GL Semenza, GL Semenza, H Liu, H Witt, Harald Kögler, HE Ryan, HH Marti, J Krishnan, J Krishnan, JR Resar, Jörg Wilting, Karl Toischer, Katrin Schäfer, Lars S. Maier, LS Maier, M Huang, M Ivan, M Kido, M Sano, MA Hlatky, Monique Silter, N Masson, O Baranova, P Fraisl, P Hill, P Jaakkola, PH Maxwell, RH Wenger, T Eckle, WG Kaelin Jr, WM Bernhardt, WM Bernhardt, Y Huang, Y Jiang, Z Cai   +46 more
core   +2 more sources

Left ventricular hypertrophy in emphysema [PDF]

Thorax, 1974
Edwards, C. W. (1973) . Thorax , 29 , 75-80. Left ventricular hypertrophy in emphysema . The role of systemic hypertension in 10 emphysematous subjects with left ventricular hypertrophy was investigated. The medial thickness of the internal mammary artery was used as a parameter of raised systemic blood pressure during life.
openaire   +3 more sources