Results 111 to 120 of about 301,871 (346)

PARPi Combining Nanoparticle LIN28B siRNA for the Management of Malignant Ascites

Advanced Science, EarlyView.
This study demonstrates that co‐inhibition of LIN28B and PARP using siLin28b/DSSP@lip‐PEG‐FA nanoparticles in combination with the PARP inhibitor BMN673 effectively suppresses the accumulation of malignant ascites associated with advanced cancers.
Yan Fang, Qian Shen, Yao Lin, Jing Zhu, Xiaolan Zhu, Rui Huang, Yijia Wu, Feiyang Shen, Qian Li, Guopei Zheng, Zhe Zhang, Qian Chu, Junhao Hu, Jianfeng Shen   +13 more
wiley   +1 more source

Prenatal hypoxia induces increased cardiac contractility on a background of decreased capillary density. [PDF]

, 2009
Background: Chronic hypoxia in utero (CHU) is one of the most common insults to fetal development and may be associated with poor cardiac recovery from ischaemia-reperfusion injury,yet the effects on normal cardiac mechanical performance are poorly ...
A Heintz, A Huang, AL Greene, AM Coney, AM Lewis, AM Shah, AM Ziada, C Muhlfeld, CS Broberg, D Song, DA Myers, David Hauton, DG Hemmings, DJ Barker, DL Baker, DS Loose, EP Tsagalou, G Li, GA Haywood, GL Engelmann, H He, H Luss, HB Corstius, JE Baker, JL Balligand, JL Morrison, JW Phillis, KA Schenkman, L Kuo, LP Thompson, M Felaco, MA Talukder, MP Kingsbury, NV Iyer, P Knaapen, PJ Fletcher, R Chaoui, R Grocott-Mason, S Bae, S Batra, S Fujita, S Siedner, SKL Ellington, SM Wildhirt, SR Kayar, SR Powell, T Mattfeldt, T Murashita, TH Shepard, V Guarner, Victoria Ousley, WJ Paulus, Y Chen, Y Dong, Y Xu, YZ Cheng   +55 more
core   +4 more sources

The Mitochondrial Guardian α‐Amyrin Mitigates Alzheimer's Disease Pathology via Modulation of the DLK‐SARM1‐ULK1 Axis

Advanced Science, EarlyView.
Dietary habits play a key role in chronic diseases, and higher annual consumption of fruit and vegetable may lower risk of dementia. Artificial intelligence predicts the lipid‐like compound α‐Amyrin (αA) from plants with edible peels as a drug candidate against Alzheimer's disease.
Shu‐Qin Cao, Juan Ignacio Jiménez‐Loygorri, Yunguang Qiu, You Jung Kang, Khanh Van Do, Annabel E. Smith, Junjie Huang, Jun‐ping Pan, Lipeng Mao, Ang Li, Hangge Yang, Yahyah Aman, Maria Jose Donate Lagartos, Sofie Hindkjær Lautrup, Anbin Chen, Kristina Xiao Liang, Hailong Zhang, Juan Yi, Xurui Jin, Tin Cho Cheung, Olympia Apokotou, Florentia Papastefanaki, Rebecca Matsas, William A. McEwan, Feixiong Cheng, Hansang Cho, Guobing Chen, Huanxing Su, Konstantinos Palikaras, Oscar Junhong Luo, Qian Hua Zhao, Ding Ding, Cornelia van Duijn, Nektarios Tavernarakis, Patricia Boya, Tewin Tencomnao, Evandro F. Fang   +36 more
wiley   +1 more source

Cardiac Remodeling from Middle Age to Senescence

Frontiers in Physiology, 2017
Background: The data on cardiac remodeling outside the scope of myocardial infarction and heart failure are limited.Methods: A cohort of middle-aged hypertensive subjects with age- and gender-matched control subjects without hypertension (n = 1,045, aged
Mikko J. Möttönen, Olavi Ukkola, Jarmo Lumme, Y. Antero Kesäniemi, Heikki V. Huikuri, Juha S. Perkiömäki   +5 more
doaj   +1 more source

Tracking of structural and functional cardiac measures from infancy into school-age [PDF]

, 2017
Objective Cardiac structure and function are important predictors for cardiovascular disease in adults. Not much is known about tracking of cardiac measures, other than left ventricular mass, from early life onwards.
Gaillard, R. (Romy), Helbing, W.A. (Willem), Hofman, A. (Albert), Jaddoe, V.W.V. (Vincent), Osch-Gevers, M. (Lennie) van, Toemen, L. (Liza)   +5 more
core   +1 more source

Diagnostic value of troponin T for alterations in left ventricular mass and function in dialysis patients [PDF]

, 2002
Francesca Mallamaci, Carmine Zoccali, Saverio Parlongo, Giovanni Tripepi, Francesco Benedetto, Sebastiano Cutrupi, Grazia Bonanno, Pasquale Fatuzzo, Francesco Rapisarda, Giuseppe Seminara, Benedetta Stancanelli, Ignazio Bellanuova, Alessandro Cataliotti, Lorenzo Malatino   +13 more
openalex   +1 more source

Assessing the Relative Importance of Imaging and Serum Biomarkers in Capturing Disability, Cognitive Impairment, and Clinical Progression in Multiple Sclerosis

Advanced Science, EarlyView.
Using machine‐learning analyses in two independent multiple sclerosis cohorts, spinal cord atrophy and cortical degeneration emerged as key predictors of disability and progression independent of relapses. Deep gray matter damage further improved prediction, while serum biomarkers of brain damage provided complementary information, highlighting the ...
Alessandro Cagol, Pascal Benkert, Sabine Schaedelin, Mario Ocampo‐Pineda, Noemi Montobbio, Po‐Jui Lu, Batuhan Ayci, Antonia Wenger, Alfi Aran Shukur, Kornelius Kaim, Lester Melie‐Garcia, Matthias Weigel, Alessio Signori, Pasquale Calabrese, Ludwig Kappos, Maria Pia Sormani, Jens Kuhle, Cristina Granziera   +17 more
wiley   +1 more source

Normative reference ranges for echocardiographic chamber dimensions in a healthy Central European population: results from the Czech post-MONICA survey

Cardiovascular Ultrasound, 2019
Background Normative reference values for echocardiographic chamber quantification are of great importance; however, this can be challenging. Our aim was to derive these values including degrees of abnormality from a random Central European population ...
Josef Marek, Jean-Claude Lubanda, Renata Cifkova, Petr Kuchynka, Lubor Golan, Eduard Nemcek, Ales Linhart   +6 more
doaj   +1 more source

Neurohumoral and mechanical factors in the modulation of left ventricular mass [PDF]

The goals for the research were to define, describe, and study those neuroendocrine and mechanical mechanisms that may play a role in the initiation and maintenance of an increase in, or cause regression of, the mass of the left ventricle.
Franklin, Eleanor I., Hawthorne, Edward W.   +1 more
core   +1 more source

Nap1L4a Cooperates with Scl/Klf1 to Recruit H2A.Z in Mediating Interactions Among Cis‐Regulatory Elements and Transcription Required for Primitive Erythropoiesis in Zebrafish

Advanced Science, EarlyView.
Nap1l4a is required in erythropoiesis and hypoxia responses via physical interaction with Klf1 and Scl to recruit the histone variant H2A.Z. This facilitates its associated cis‐regulatory element (CRE) remodeling and the consequent chromatin assembly, and activates the transcription of erythroid lineage‐specific genes.
JiaHao Shi, FuMing Lai, Zheng Shen, XiaoYan Zhang, HanFei Wang, WenYe Liu, YunLong Wang, KuanYu Li, GuoLiang Li, YaPing Fang, Jing‐Xia Liu   +10 more
wiley   +1 more source