Results 121 to 130 of about 194,767 (337)

PARPi Combining Nanoparticle LIN28B siRNA for the Management of Malignant Ascites

Advanced Science, EarlyView.
This study demonstrates that co‐inhibition of LIN28B and PARP using siLin28b/DSSP@lip‐PEG‐FA nanoparticles in combination with the PARP inhibitor BMN673 effectively suppresses the accumulation of malignant ascites associated with advanced cancers.
Yan Fang, Qian Shen, Yao Lin, Jing Zhu, Xiaolan Zhu, Rui Huang, Yijia Wu, Feiyang Shen, Qian Li, Guopei Zheng, Zhe Zhang, Qian Chu, Junhao Hu, Jianfeng Shen   +13 more
wiley   +1 more source

Maternal Cardiovascular Impairment in Pregnancies Complicated by Severe Fetal Growth Restriction [PDF]

, 2012
—Fetal growth restriction and preeclampsia are both conditions of placental etiology and associated to increased risk for the long-term development of cardiovascular disease in the mother. At presentation, preeclampsia is associated with maternal global
Liberati, M, Melchiorre, K, Sutherland, GR, Thilaganathan, B   +3 more
core   +1 more source

The Mitochondrial Guardian α‐Amyrin Mitigates Alzheimer's Disease Pathology via Modulation of the DLK‐SARM1‐ULK1 Axis

Advanced Science, EarlyView.
Dietary habits play a key role in chronic diseases, and higher annual consumption of fruit and vegetable may lower risk of dementia. Artificial intelligence predicts the lipid‐like compound α‐Amyrin (αA) from plants with edible peels as a drug candidate against Alzheimer's disease.
Shu‐Qin Cao, Juan Ignacio Jiménez‐Loygorri, Yunguang Qiu, You Jung Kang, Khanh Van Do, Annabel E. Smith, Junjie Huang, Jun‐ping Pan, Lipeng Mao, Ang Li, Hangge Yang, Yahyah Aman, Maria Jose Donate Lagartos, Sofie Hindkjær Lautrup, Anbin Chen, Kristina Xiao Liang, Hailong Zhang, Juan Yi, Xurui Jin, Tin Cho Cheung, Olympia Apokotou, Florentia Papastefanaki, Rebecca Matsas, William A. McEwan, Feixiong Cheng, Hansang Cho, Guobing Chen, Huanxing Su, Konstantinos Palikaras, Oscar Junhong Luo, Qian Hua Zhao, Ding Ding, Cornelia van Duijn, Nektarios Tavernarakis, Patricia Boya, Tewin Tencomnao, Evandro F. Fang   +36 more
wiley   +1 more source

The Effect of “Unclassified” Blood Pressure Phenotypes on Left Ventricular Hypertrophy

Turkish Archives of Pediatrics
Objective: We aimed to evaluate the clinical significance of the “unclassified” blood pressure phenotypes on left ventricular hypertrophy in children.
Belde Kasap-Demir, Cemaliye Başaran, Tülay Demircan, Gökçen Erfidan, Özgür Özdemir-Şimşek, Seçil Arslansoyu-Çamlar, Demet Alaygut, Fatma Mutlubaş, Cem Karadeniz   +8 more
doaj   +1 more source

An Observational Study on the Reversibility of Left Ventricular Diastolic Dysfunction, Impaired Left Ventricular Ejection Fraction and Abnormal Left Ventricular Mass with Levothyroxine Replacement in Primary Hypothyroid Patients of Indian Origin [PDF]

Bengal Physician Journal
Background: Cardiovascular performance is well-known to be compromised due to low level of thyroid hormone levels in terms of reduced cardiac performance, reduced chronotropy, and increased systemic vascular resistance.
Abhirup Chatterjee, Anupam Mandal, Sattik Siddhanta, Rajdip Sen   +3 more
doaj   +1 more source

Assessing the Relative Importance of Imaging and Serum Biomarkers in Capturing Disability, Cognitive Impairment, and Clinical Progression in Multiple Sclerosis

Advanced Science, EarlyView.
Using machine‐learning analyses in two independent multiple sclerosis cohorts, spinal cord atrophy and cortical degeneration emerged as key predictors of disability and progression independent of relapses. Deep gray matter damage further improved prediction, while serum biomarkers of brain damage provided complementary information, highlighting the ...
Alessandro Cagol, Pascal Benkert, Sabine Schaedelin, Mario Ocampo‐Pineda, Noemi Montobbio, Po‐Jui Lu, Batuhan Ayci, Antonia Wenger, Alfi Aran Shukur, Kornelius Kaim, Lester Melie‐Garcia, Matthias Weigel, Alessio Signori, Pasquale Calabrese, Ludwig Kappos, Maria Pia Sormani, Jens Kuhle, Cristina Granziera   +17 more
wiley   +1 more source

Cardiac magnetic resonance findings predict increased resource utilization in elective coronary artery bypass grafting [PDF]

, 2008
Morbidity following CABG (coronary artery bypass grafting) is difficult to predict and leads to increased healthcare costs. We hypothesized that pre-operative CMR (cardiac magnetic resonance) findings would predict resource utilization in elective CABG ...
Alfakih, American Heart Association, Anna F. Dominiczak, Baks, Bellenger, Berry, Berry, British Heart Foundation Heart Statistics, Christian Delles, Colin Berry, Eisenberg, Ferguson, Fieno, Geissler, Geoffrey A. Berg, Gibbons, Hein, Henry J. Dargie, Higgins, Higgins, Hombach, John E. Foster, Lassnigg, Lorenz, Lukas U. Zimmerli, Lund, Mark, Michalopoulos, Mosteller, Mounsey, Nathanson, Pell, Pennell, Roques, Rosamond, Schvartzman, Selvanayagam, Sievers, Simonetti, Tracey Steedman, Tu, Tu, Zimmerli   +42 more
core   +1 more source

Isolated left ventricular assist device implantation produces variable changes to patient body mass index

, 2022
Sonal Chandratre, Nathan J. Smith, Richard Walsh, Tammy L. Kindel, Sakthi Sundararajan, David L. Joyce, Abdu Mohammed   +6 more
openalex   +2 more sources

Impact of Long‐Term Burden of Body Mass Index and Blood Pressure From Childhood on Adult Left Ventricular Structure and Function [PDF]

, 2020
Yang Liu, Yinkun Yan, Tingbo Jiang, Shengxu Li, Yajun Guo, Camilo Fernandez, Rupert Barshop, Lydia Bazzano, Jiang He, Wei Chen   +9 more
openalex   +1 more source

Nap1L4a Cooperates with Scl/Klf1 to Recruit H2A.Z in Mediating Interactions Among Cis‐Regulatory Elements and Transcription Required for Primitive Erythropoiesis in Zebrafish

Advanced Science, EarlyView.
Nap1l4a is required in erythropoiesis and hypoxia responses via physical interaction with Klf1 and Scl to recruit the histone variant H2A.Z. This facilitates its associated cis‐regulatory element (CRE) remodeling and the consequent chromatin assembly, and activates the transcription of erythroid lineage‐specific genes.
JiaHao Shi, FuMing Lai, Zheng Shen, XiaoYan Zhang, HanFei Wang, WenYe Liu, YunLong Wang, KuanYu Li, GuoLiang Li, YaPing Fang, Jing‐Xia Liu   +10 more
wiley   +1 more source