Advanced Science, EarlyView.IPA is an intestinal tryptophan metabolite whose effects decline with decreased heart function. Supplementing IPA can alleviate the aging‐related myocardial fibrosis through PPT1. PPT1 is a key protein localized to lysosomes, and IPA can restore macrophage autophagy function by regulating PPT1 expresssions, thereby reducing aging‐related myocardial ...
Jing Lu +16 more
wiley +1 more source
Effects of vildagliptin on ventricular function in patients with type 2 diabetes mellitus and heart failure: a randomized placebo-controlled trial [PDF]
, 2017 Objectives: This study sought to examine the safety of the dipeptidyl peptidase-4 inhibitor, vildagliptin, in patients with heart failure and reduced ejection fraction.
Bolli, Geremia B. +7 more
core +2 more sources
Advanced Science, EarlyView.Oral aspirin administration induces intestinal expansion of Lactobacillus murinus and Lactobacillus johnsonii, which suppresses the progression of atherosclerosis. This microbial expansion significantly enhances butyrate production by providing lactate as a metabolic substrate, thereby fostering the growth of butyrate‐producing bacteria. Butyrate plays
Rui Hua +15 more
wiley +1 more source
An Observational Study on the Reversibility of Left Ventricular Diastolic Dysfunction, Impaired Left Ventricular Ejection Fraction and Abnormal Left Ventricular Mass with Levothyroxine Replacement in Primary Hypothyroid Patients of Indian Origin [PDF]
Bengal Physician JournalBackground: Cardiovascular performance is well-known to be compromised due to low level of thyroid hormone levels in terms of reduced cardiac performance, reduced chronotropy, and increased systemic vascular resistance.
Abhirup Chatterjee +3 more
doaj +1 more source
The effect of sacubitril/valsartan compared to olmesartan on cardiovascular remodelling in subjects with essential hypertension: the results of a randomized, double-blind, active-controlled study [PDF]
, 2017 Aims: Progressive aortic stiffening eventually leads to left ventricular (LV) hypertrophy and heart failure if left untreated. Anti-hypertensive agents have been shown to reverse this to some extent. The effects of sacubitril/valsartan (LCZ696), a dual-
Aichner, Solveig +15 more
core +1 more source
Advanced Science, EarlyView.Cardiovascular disease (CVD) and cancer are leading causes of death worldwide, with overlapping risk factors and pathophysiological mechanisms. This review explores shared pathways, including metabolic dysregulation, chronic inflammation, and gut microbiome alterations, highlighting dual‐benefit strategies such as lifestyle modifications and repurposed
Shihan Xiang +6 more
wiley +1 more source
The Effect of “Unclassified” Blood Pressure Phenotypes on Left Ventricular Hypertrophy
Turkish Archives of PediatricsObjective: We aimed to evaluate the clinical significance of the “unclassified” blood pressure phenotypes on left ventricular hypertrophy in children.
Belde Kasap-Demir +8 more
doaj +1 more source
Modifiable predictors of ventricular ectopy in the community [PDF]
, 2018 Background Premature ventricular contractions (PVCs) predict heart failure and death. Data regarding modifiable risk factors for PVCs are scarce. Methods and Results We studied 1424 Cardiovascular Health Study participants randomly assigned to 24-hour ...
Dewland, Thomas A +5 more
core +2 more sources
Echocardiography combined with cardiopulmonary exercise testing for the prediction of outcome in idiopathic pulmonary arterial hypertension [PDF]
, 2016 BACKGROUND: Right ventricular (RV) function is a major determinant of exercise intolerance and outcome in idiopathic pulmonary arterial hypertension (IPAH). The aim of the study was to evaluate the incremental prognostic value of echocardiography of the
Badagliacca, Roberto +11 more
core +1 more source
Advanced Science, EarlyView.MANF in cardiomyocytes interacts with BAX to impede BAX mitochondrial translocation and cytochrome c release, further stabilizing mitochondrial structure and energy supply to relieve myocardial apoptosis and hypertrophy, which indicates MANF as a novel cardioprotective factor to have a promising clinical application for myocardial hypertrophy ...
Dong Wang +13 more
wiley +1 more source