Results 141 to 150 of about 9,025,884 (293)

CHANGES IN THE LEVELS OF ST2 AND GALECTIN-3 IN THE BLOOD SERUM OF PATIENTS WITH ARTERIAL HYPERTENSION

Proceedings of the Shevchenko Scientific Society: Medical Sciences
Introduction. Soluble suppression of tumorigenicity 2 (sST2) and galectin-3 are considered markers of myocardial hypertrophy and fibrosis. Changes in their concentrations are observed in cardiovascular diseases, including arterial hypertension.
Oksana Kapustynska, Helen Sklyarova, Nataliia Denysenko, Orest Chemerys, Lesya Kobylinska, Eugen Sklyarov, Sandor Vari   +6 more
doaj   +1 more source

Physiological and clinical consequences of relief of right ventricular outflow tract obstruction late after repair of congenital heart defects. [PDF]

, 2006
BACKGROUND: Right ventricular outflow tract obstruction (RVOTO) is a common problem after repair of congenital heart disease. Percutaneous pulmonary valve implantation (PPVI) can treat this condition without consequent pulmonary regurgitation or ...
Sridharan, S, Schievano, S, Coats, L, Jones, R, Mist, B, Taylor, AM, Deanfield, JE, Bonhoeffer, P, Derrick, G, Khambadkone, S, Pellerin, D   +10 more
core  

The association between left ventricular mass index and the severity of aortic stenosis or valvuloarterial impedance.

, 2015
Males consistently showed relatively higher left ventricular mass index in (A) larger aortic valve area index, (B) lower mean transaortic pressure gradient, or (C) lower valvuloarterial impedance, compared with females.
Seung Woo Park (193961), Sang-Chol Lee (713147), Sung-A Chang (713145), Sung-Ji Park (713142), Seung-Pyo Lee (713143), Yong-Jin Kim (697275), Yeon Hyeon Choe (713149), Hyung-Kwan Kim (713146), Whal Lee (400941), Eunah Park (713144), Joo Myung Lee (654340), Dae-Won Sohn (713148)   +11 more
core   +1 more source

Drug Repurposing for Treating NCOR‐Related Intellectual Disability

Advanced Science, EarlyView.
An autism‐associated NCOR1 heterozygous mutation upregulates NRGs and activates NRG backward signaling in hypothalamic GABAergic neurons in mouse models, leading to Gabra2 downregulation and cognitive deficits, which can be therapeutically targeted by repurposing FDA‐approved drugs.
Yan Kong, Wenjun Zhou, Yuxiang Sun, Zihan Huang, Zhiyue Liu, Udhaya Kumar. S, Chenyan Li, Yi Lu, Chengchuang Song, Veronica C. Ciliberto, Makenna Mack, Lana E. Kim, Zhaoyong Hu, Fang Luo, Aihua Cao, Zheng Sun   +15 more
wiley   +1 more source

Optimizing Cancer Vaccinations Using a Physiologically‐Based Pharmacokinetic/Pharmacodynamic (PBPK/PD) Model

Advanced Science, EarlyView.
Where and when should a cancer vaccine be administered? A whole‐body PBPK model demonstrates that systemic immune transport critically determines vaccination efficacy. By simulating how organ‐specific immune interactions influence treatment response, the study provides a quantitative framework for optimizing cancer vaccination strategies.
Mohammad R. Nikmaneshi, Timothy P. Padera, Lance L. Munn   +2 more
wiley   +1 more source

Left Ventricular Mass Index [PDF]

, 2020
openaire   +1 more source

Alkylating Agent–Induced FANCL Impairment Damages Pulmonary Arterial, Venous, and Microvascular Endothelial Cells and Predisposes to PAH/PVOD

Advanced Science, EarlyView.
This study establishes a novel cisplatin‐induced rat model of PAH/PVOD and identifies a conserved mechanistic axis—FANCL impairment, DNA damage accumulation, and endothelial dysfunction—triggered by cisplatin or mitomycin C across pulmonary arteries, veins, and microvessels.
Shiyun Liu, Yufei Sun, Xinlei Wu, Haixia Chen, Shaocong Mo, Zichong Li, Yiwei Gong, Xiaoqian Shan, Yuanqi Li, Yaru Guan, Junqi Zhu, Han Yan, Min Du, Feng Wei, Peixin Ou, Ziyi Wang, Chenting Zhang, Lei Xu, Wenju Lu, Jian Wang, Kai Yang   +20 more
wiley   +1 more source

Independent risk factors of left ventricular hypertrophy in non-diabetic individuals in Sierra Leone - a cross-sectional study

Lipids in Health and Disease
Background Left ventricular hypertrophy (LVH) is a critical factor in heart failure and cardiovascular event-related mortality. While the prevalence of LVH in diabetic patients is well-documented, its occurrence and risk factors in non-diabetic ...
Yuanxin Xu, Yingxin Celia Jiang, Lihua Xu, Weiyu Zhou, Zhiying Zhang, Yanfei Qi, Hongyu Kuang, Shuang Yan   +7 more
doaj   +1 more source

Yoda1‐Functionalized Nanozymes Coordinate Piezo1 Activation and Mitochondrial Protection to Reprogram the Diabetic Osteoimmune Micromilieu and Promote Vascularized Bone Repair

Advanced Science, EarlyView.
Diabetic bone defects remain a critical clinical challenge. A 3D‐printed BCPG‐MF@Y scaffold, embedding Yoda1‐functionalized manganese dioxide‐ferritin nanozymes, scavenges mtROS, suppresses the cGAS–STING pathway, and reverses cellular senescence, while Yoda1 activates Piezo1 to direct BMSCs fate to synergistically reprogram the osteoimmune ...
Qing‐Song Deng, Ang Wang, Ren Zhang, Xu‐Ran Li, Po‐Lin Liu, Shu‐Hang He, Zi‐Yin Han, Zhi‐Han Shen, Zhan‐Ying Wei, Chang‐Ru Zhang, Fei Wang, Helen Dawes, Jian Lu, Tong‐He Zhu, Jin‐Zhong Zhao, Shang‐Chun Guo, Shi‐Cong Tao   +16 more
wiley   +1 more source

Overweight and early heart remodelling in women with arterial hypertension

Кардиоваскулярная терапия и профилактика, 2010
Aim. To compare left ventricular (LV) remodelling and LV myocardial mass indices (MMI) in overweight and nonoverweight women with arterial hypertension (AH). Material and methods.
E. M. Khurs, A. N. Dmitriev, P. V. Andreev, A. V. Poddubnaya, M. G. Evsina, O. G. Smolenskaya   +5 more
doaj