Results 161 to 170 of about 9,025,884 (293)

Ultrasound‐Triggered piRNA Delivery Using Biomimetic Phase‐Changeable Nanoparticles for Theranostics of Myocardial Infarction

open access: yesAdvanced Science, EarlyView.
A biomimetic ultrasound‐responsive piRNA delivery nanoparticle platform (piR‐NPs) enables targeted delivery and ultrasound (US)‐triggered release of piR‐1873 in infarcted myocardium. The released piR‐1873 suppresses Usp2‐mediated RIP1/RIP3/MLKL necroptosis, reduces myocardial injury and fibrosis, and promotes cardiac functional recovery, providing a ...
Yajun Zhang   +10 more
wiley   +1 more source

Nocturnal Dipping and Left Ventricular Mass Index in the Chronic Kidney Disease in Children Cohort. [PDF]

open access: yesClin J Am Soc Nephrol, 2022
Bakhoum CY   +6 more
europepmc   +1 more source

A Chiral Virus‐Like Nanoplatform That Broadly Mediates Antibiotic Delivery to the Brain for Bacterial Meningitis Therapy

open access: yesAdvanced Science, EarlyView.
Chiral virus‐mimicking mesoporous silica nanostructures (CVSNs) efficiently transport diverse antibiotics across the blood–brain barrier (BBB) into brain parenchyma and cerebrospinal fluid. By enhancing delivery to microglia and astrocytes, CVSNs improve antibiotic bioavailability and therapeutic efficacy against both Gram‐negative and Gram‐positive ...
Qianqian Xu   +11 more
wiley   +1 more source

Left ventricular mass index-to-QRS-voltage ratio predicts outcomes in heart failure with preserved ejection fraction. [PDF]

open access: yesESC Heart Fail, 2022
Kinugasa Y   +11 more
europepmc   +1 more source

Macrophage GLUD1 is Essential for Redox Balance and Immune Homeostasis in Cardiac Injury

open access: yesAdvanced Science, EarlyView.
Excessive free radical production and dysregulated immune responses are key contributors to myocardial ischemia‐reperfusion (IR) injury. Macrophage GLUD1 activity safeguards against HIF‐1α accumulation and maladaptive responses to IR‐induced ROS production.
Tingting Jin   +16 more
wiley   +1 more source

Nocturnal blood pressure surge in seconds is a new determinant of left ventricular mass index. [PDF]

open access: yesJ Clin Hypertens (Greenwich), 2022
Kokubo A   +6 more
europepmc   +1 more source

Human Engineered Heart Tissues Reproduce Trigger‐ and Substrate‐Driven Mechanisms of Ventricular Tachycardia

open access: yesAdvanced Science, EarlyView.
Engineered heart tissues (EHTs) derived from human iPSCs replicate mechanisms of ventricular tachycardia at the tissue level. Acquired Long‐QT conditions cause early afterdepolarizations, wavebreak, and transient rotors; in contrast, focal cryoinjury forms a stable substrate that supports ongoing reentry.
Matthew Fiedler   +4 more
wiley   +1 more source

CLINICAL AND DIAGNOSTIC FEATURES OF AORTIC STENOSIS

open access: yesКубанский научный медицинский вестник, 2015
Early diagnosis of aortic stenosis may begin with the identification of left ventricular hypertrophy by two-dimensional Doppler echocardiography. For aortic stenosis characterized by concentric left ventricular remodeling, when the index for normal left ...
S. M. Gerasimenko   +3 more
doaj  

Variation at the beta-1 adrenoceptor gene locus affects left ventricular mass in renal failure

open access: yes, 2002
Objectives: To examine the relationship between this variation in the β1AR gene and the effect on LV mass. Background: Left ventricular (LV) mass is an important cardiovascular risk factor.
Jardine, AG   +5 more
core  

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