A UBE3A‐UTX Proteostasis‐Epigenetic Axis Governs Hypothalamic Energy Homeostasis
Ubiquitin protein ligase E3A (UBE3A) regulates hypothalamic energy homeostasis and promotes degradation of the histone demethylase UTX (KDM6A). Neuronal UBE3A loss increases susceptibility to diet‐induced obesity and is accompanied by UTX accumulation, reduced histone H3 lysine 27 trimethylation, and altered endoplasmic reticulum stress‐responsive gene
Junekyoung Lee +7 more
wiley +1 more source
CKMT1 inhibits VDAC1 oligomerization via a dual‐region mechanism: its NTD interacts with the VDAC1 C‐terminal domain, while residues 1–39 sterically hinder dimerization, thereby reducing mtDNA leakage and AIM2 inflammasome activation, suppressing neuronal pyroptosis and protecting against cerebral ischemic injury. ABSTRACT Ischemic stroke is one of the
Xiaoyu Wang +17 more
wiley +1 more source
Left Ventricular Mass Index as an independent predictor of major adverse cardiovascular and cerebrovascular events in patients with SLE. [PDF]
Chen J, Zhou X.
europepmc +1 more source
Relationship between doses of antihypertensive drugs and left ventricular mass index changes in hemodialysis patients in a Japanese cohort. [PDF]
Kitamura F +14 more
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Ambulatory Blood Pressure Patterns and Left Ventricular Mass Index in Tanzanian Adults Living with and without HIV. [PDF]
Willkens M +13 more
europepmc +1 more source
Reply to "Impact of obstructive sleep apnea on left ventricular mass index in men with coronary artery disease". [PDF]
Azarbarzin A, White DP.
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941 Left ventricular mass and left ventricular function indexes in obese hypertensive patients [PDF]
openaire +1 more source
Automatic left ventricular segmentation in echocardiography is critical for cardiac function assessment but remains challenging due to limited crossdomain feature interaction. This paper proposes SFMFNet, a Spatial‐Frequency Multi‐Scale Fusion Network that integrates multiscale convolution, wavelet transform, and Fourier transform.
Dang Li +3 more
wiley +1 more source
Impact of Left Ventricular Mass Index and Geometric Pattern on Right Ventricular Dimensions and Function in Hypertensive Patients Using Dual-Source Computed Tomography. [PDF]
Soliman LT, Elramly MZ, Shehatah A.
europepmc +1 more source
Assessment of Carotid Intima Media Thickness and Left Ventricular Mass Index in Children with Idiopathic Nephrotic Syndrome. [PDF]
Ahmed HM, Ameen EE, Awad MS, Botrous OE.
europepmc +1 more source

