Results 181 to 190 of about 9,025,884 (293)

A UBE3A‐UTX Proteostasis‐Epigenetic Axis Governs Hypothalamic Energy Homeostasis

open access: yesAdvanced Science, EarlyView.
Ubiquitin protein ligase E3A (UBE3A) regulates hypothalamic energy homeostasis and promotes degradation of the histone demethylase UTX (KDM6A). Neuronal UBE3A loss increases susceptibility to diet‐induced obesity and is accompanied by UTX accumulation, reduced histone H3 lysine 27 trimethylation, and altered endoplasmic reticulum stress‐responsive gene
Junekyoung Lee   +7 more
wiley   +1 more source

CKMT1 Counteracts VDAC1 Oligomerization‐Induced Neuronal Pyroptosis Through Steric Hindrance in Ischemic Stroke

open access: yesAdvanced Science, EarlyView.
CKMT1 inhibits VDAC1 oligomerization via a dual‐region mechanism: its NTD interacts with the VDAC1 C‐terminal domain, while residues 1–39 sterically hinder dimerization, thereby reducing mtDNA leakage and AIM2 inflammasome activation, suppressing neuronal pyroptosis and protecting against cerebral ischemic injury. ABSTRACT Ischemic stroke is one of the
Xiaoyu Wang   +17 more
wiley   +1 more source

Relationship between doses of antihypertensive drugs and left ventricular mass index changes in hemodialysis patients in a Japanese cohort. [PDF]

open access: yesRen Fail, 2021
Kitamura F   +14 more
europepmc   +1 more source

Ambulatory Blood Pressure Patterns and Left Ventricular Mass Index in Tanzanian Adults Living with and without HIV. [PDF]

open access: yesGlob Heart
Willkens M   +13 more
europepmc   +1 more source

SFMFNet: Spatial‐Frequency Multiscale Fusion Network for Left Ventricle Segmentation in Echocardiography

open access: yesAdvanced Intelligent Systems, EarlyView.
Automatic left ventricular segmentation in echocardiography is critical for cardiac function assessment but remains challenging due to limited crossdomain feature interaction. This paper proposes SFMFNet, a Spatial‐Frequency Multi‐Scale Fusion Network that integrates multiscale convolution, wavelet transform, and Fourier transform.
Dang Li   +3 more
wiley   +1 more source

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