Results 51 to 60 of about 2,680,249 (282)

Optimizing Cancer Vaccinations Using a Physiologically‐Based Pharmacokinetic/Pharmacodynamic (PBPK/PD) Model

Advanced Science, EarlyView.
Where and when should a cancer vaccine be administered? A whole‐body PBPK model demonstrates that systemic immune transport critically determines vaccination efficacy. By simulating how organ‐specific immune interactions influence treatment response, the study provides a quantitative framework for optimizing cancer vaccination strategies.
Mohammad R. Nikmaneshi, Timothy P. Padera, Lance L. Munn   +2 more
wiley   +1 more source

Iatrogenic postoperative left ventricular outflow tract obstruction [PDF]

Clinical Cardiology, 1983
AbstractA 56‐year‐old female, who underwent aortocoronary bypass graft for occlusion of anterior descending artery is reported, who postoperatively developed a harsh systolic murmur, mitral regurgitation, and intraventricular systolic pressure gradient suggestive of hypertrophic subaortic stenosis.
F K, Nakhjavan, S, Yazdanfar, V, Bhasin, H, Goldberg   +3 more
openaire   +2 more sources

A Hypothalamic Oxytocinergic–Sympathetic Axis Couples Anxiety Dysregulation With Impaired Tendon–Bone Repair

Advanced Science, EarlyView.
RCI is associated with functional suppression of oxytocinergic neurons in the PVN. Reduced PVNOXT neuronal activity contributes to altered sympathetic regulation involving the IML–sympathetic chain pathway, accompanied by changes in norepinephrine signaling at the BTI.
Liyang Wan, Tingmo Huang, Liyue Zeng, Ruixue Du, Hengshuo Zhang, Shen Liu, Tao Zhang, Jianzhong Hu, Hongbin Lu   +8 more
wiley   +1 more source

Giant Cardiac Rhabdomyoma with Mixed Atrial Tachycardia and Nonsustained Ventricular Tachycardia in a Newborn with Tuberous Sclerosis

The Ewha Medical Journal, 2022
Cardiac rhabdomyomas are typically presented in the tuberous sclerosis. Although benign and often associated with spontaneous regression, in rare circumstances huge mass size and critical location can lead to heart failure, ventricular outflow tract ...
Kyung Hee Kim, Ji-Eun Ban
doaj   +1 more source

Meningeal Lymphatic LTBR Deficiency Links Spinal Cord Injury to Secondary Brain Pathology

Advanced Science, EarlyView.
Spinal cord injury (SCI) induces remote brain alterations beyond the injured spinal cord. This study links dysfunction of meningeal lymphatic vessels (mLVs) to neuroinflammation and neuronal injury after SCI. LTBR‐mediated lymphatic restoration improves meningeal lymphatic integrity and neurological outcomes, highlighting LTBR as a potential regulator ...
Yi Chen, Yu Tang, Chengpeng Hu, Xiaoyan Duan, LingXia Min, Boya Cong, Chao Ma, Mingliang Tan, Ya Luo, Pengfei Wei, Minpeng Xu, Zhou Feng, Jingming Hou   +12 more
wiley   +1 more source

Anaesthetic management of a patient with hypertrophic obstructive cardiomyopathy posted for emergency lower segment caesarean section

Journal of Obstetric Anaesthesia and Critical Care, 2017
Hypertrophic cardiomyopathy is characterised by asymmetric hypertrophy of the interventricular septum causing intermittent obstruction of the left ventricular outflow tract.
Pradnya M Bhalerao, Pritam B Adsule, Radhika M Marathe   +2 more
doaj   +1 more source

Improving left ventricular outflow tract obstruction repair in common atrioventricular canal defects

, 2012
Left ventricular outflow tract obstruction (LVOTO) is the second most frequent reason for reoperation after atrioventricular canal (AVC) defect repair.
Emani, Sitaram, Pigula, Frank A, Myers, Patrick Olivier, del Nido, Pedro J, Baird, Christopher W, Marx, Gerald R, Mayer, John E (Jr)   +6 more
core   +1 more source

Implantable Systems for Cardiovascular Treatment and Monitoring: Comparative Insights From Intracardiovascular and Extracardiovascular Technologies

Advanced Intelligent Systems, EarlyView.
A unifying device–cardiovascular interface framework is presented to classify implantable cardiovascular technologies as intracardiovascular blood‐contacting systems or extracardiovascular tissue‐only and blood‐handling architectures. Cross‐class comparison across shared semiquantitative criteria, including blood‐contact burden, biomimicry ...
Bergo Nicolò, Semproni Federica, Maselli Martina, Colli Andrea, Cianchetti Matteo, Ciuti Gastone, Stefanini Cesare, Menciassi Arianna   +7 more
wiley   +1 more source

Unexpected systolic anterior motion of the mitral valve-related hypoxemia during transurethral resection of the prostate under spinal anesthesia: a case report

BMC Anesthesiology, 2022
Background Dynamic obstruction of the left ventricular outflow tract resulting from systolic anterior motion of the mitral valve can be an unexpected cause of acute and severe perioperative hypotension in noncardiac surgery.
Chien-Ju Chou, Yi-Chen Lai, Shu-Yu Ou, Chen-Hsiu Chen   +3 more
doaj   +1 more source

The Apex Cardiogram in Left Ventricular Outflow Tract Obstruction [PDF]

Circulation, 1964
The use of the apex cardiogram offers a simple yet valuable aid in the diagnosis of obstruction of the left ventricular outflow tract. Characteristic changes in the ejection component of the apex cardiogram distinguish obstruction due to hypertrophic subaortic stenosis from obstruction due to valvular aortic stenosis.
E, TAFUR, L S, COHEN, H D, LEVINE
openaire   +2 more sources