Results 41 to 50 of about 150,466 (311)

Early assessment of percutaneous coronary interventions for chronic total occlusions analyzed by novel echocardiographic techniques

Clinics, 2013
OBJECTIVE: Successful revascularization of chronic total occlusions has been associated with improved left ventricular systolic function, reduced anginal symptoms, increased exercise capacity, and increased survival. This study was conducted to determine
Ercan Erdogan, Mehmet Akkaya, Ahmet Bacaksiz, Abdurrrahman Tasal, Osman Sonmez, Mehmet Ali Elbey, Seref Kul, Mehmet Akif Vatankulu, Murat Turfan, Omer Goktekin   +9 more
doaj   +1 more source

Massive Mobile Left Ventricular Thrombus in a Patient With Normal Left Ventricular Systolic Function [PDF]

CASE, 2019
[Figure: see text]
Gregory Papadopoulos, Arismendy Nunez, Richard Grodman, Aytan Mamadova, Zalmi Rahmany, Ahmed El-Eshmawi, Yansheng Hao, Bhavesh Gala   +7 more
openaire   +3 more sources

Irisin Attenuates Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension via Ubiquitin‐Mediated Regulation of ENO1

Advanced Science, EarlyView.
Irisin is a crucial plasma biomarker and promising therapeutic target that reflects disease severity, pulmonary vascular remodeling status and clinical outcome in patients with pulmonary arterial hypertension (PAH). As a novel protective factor, irisin is downregulated in PAH. By ubiquitination, irisin promotes Enolase 1 degradation and suppresses cell
Na Sun, Yong‐Bing Wang, Jing Huang, Run‐Wei Deng, Hui‐Yu He, Lei Gao, Xuan Gao, You‐Li Fan, Yan Cong, Yao‐Lei Guo, Yi‐Qiang Chen, Gui‐Jia Wang, Shao‐Hong Fang, Xia Gu, Bo Yu, Bing‐Xiang Wu   +15 more
wiley   +1 more source

Cardiovascular Disease Meets Cancer: Exploring the Epidemiology in China and Homotherapy Targeting Intersectional Mechanisms

Advanced Science, EarlyView.
Cardiovascular disease (CVD) and cancer are leading causes of death worldwide, with overlapping risk factors and pathophysiological mechanisms. This review explores shared pathways, including metabolic dysregulation, chronic inflammation, and gut microbiome alterations, highlighting dual‐benefit strategies such as lifestyle modifications and repurposed
Shihan Xiang, Yujie Shan, Shihong Xu, Jing Wang, Meng Luo, Jiaojiao Zhou, Qishan Chen   +6 more
wiley   +1 more source

Mesencephalic Astrocyte‐Derived Neurotrophic Factor Binds BAX to Preserve Mitochondrial Homeostasis and Energy Metabolism for Relieving Myocardial Hypertrophy

Advanced Science, EarlyView.
MANF in cardiomyocytes interacts with BAX to impede BAX mitochondrial translocation and cytochrome c release, further stabilizing mitochondrial structure and energy supply to relieve myocardial apoptosis and hypertrophy, which indicates MANF as a novel cardioprotective factor to have a promising clinical application for myocardial hypertrophy ...
Dong Wang, Xinru Zhang, Baolong Wang, Haipeng Li, Dongshuo Xu, Yun Yang, Jialu Zhang, Wenbing Wang, Ren Zhang, Xinyu Wang, Yunfeng Cai, Shiyu Cao, Chao Hou, Changhui Wang   +13 more
wiley   +1 more source

Right Ventricular Morphology and Systolic Function in Left Ventricular Noncompaction Cardiomyopathy [PDF]

The American Journal of Cardiology, 2014
The distinction between normal right ventricular (RV) trabeculations from abnormal has been difficult. We evaluated whether RV volume and function are related to left ventricular (LV) noncompaction (NC) cardiomyopathy and clinical events. Trabeculations or possible LVNC by cardiac magnetic resonance imaging was retrospectively observed among 105 ...
Stacey, Richard Brandon, Andersen, Mousumi, Haag, Jason, Hall, Michael E, McLeod, George, Upadhya, Bharathi, Hundley, William Gregory, Thohan, Vinay   +7 more
openaire   +4 more sources

The Role of HINT3 in Myocardial Ischemia‐Reperfusion Injury in Male Mice: Mechanisms Involving SDHA and its Acetylation

Advanced Science, EarlyView.
HINT3 expression declines after myocardial ischemia‐reperfusion injury. In male mice, loss of HINT3 worsens cardiac injury and mitochondrial dysfunction, while its overexpression is protective. HINT3 binds the mitochondrial enzyme succinate dehydrogenase (SDHA) and prevents its deacetylation by histone deacetylase 1 (HDAC1), reducing succinate ...
Jiabin Yu, Qi Yao, Tongtong Hu, Yadan Zhang, Ying Liu, Yang Xiao, Qingqing Wu, Qizhu Tang   +7 more
wiley   +1 more source

Activation of Spinal Astrocyte α2A Adrenoceptors Protects Against Sepsis‐Induced Heart Injury Through Inhibition of GABAergic Neuronal Necroptosis

Advanced Science, EarlyView.
The study in this paper found that activating the α2A receptors of astrocytes in the thoracic spinal cord can reduce the release of inflammatory factors, thereby decreasing the necroptosis of GABAergic neurons and consequently alleviating myocardial injury caused by sepsis.
Ruilin He, Bin Wu, Liuhu Han, Mingde Li, Wenli Guo, Jiajing Fu, Bin Mei, Eric R. Gross, Xuesheng Liu, Yao Lu   +9 more
wiley   +1 more source

Correlation of systolic and diastolic blood pressure with echocardiographic phenotypes of cardiac structure and function from three German population-based studies

Scientific Reports, 2023
Arterial hypertension is considered a risk factor for the development of heart failure. Here we investigate cross-sectional associations of systolic and diastolic blood pressure with subtle functional and morphological changes of left ventricular ...
Julius Nikorowitsch, Ramona Bei der Kellen, Alena Haack, Christina Magnussen, Jürgen Prochaska, Philipp S. Wild, Marcus Dörr, Raphael Twerenbold, Renate B. Schnabel, Paulus Kirchhof, Stefan Blankenberg, Marcello Ricardo Paulista Markus, Jan-Per Wenzel   +12 more
doaj   +1 more source

ER‐phagy Activation by AMFR Attenuates Cardiac Fibrosis Post‐Myocardial Infarction via mTORC1 Pathway

Advanced Science, EarlyView.
By catalyzing FAM134B ubiquitination and activating ER‐phagy, AMFR alleviates progressive fibrosis and cardiac dysfunction by inhibiting the mTORC1 pathway. Consequently, these findings underscore the essential role of AMFR‐driven ER‐phagy in mitigating the progression of fibrotic responses, offering a potential therapeutic target for preventing heart ...
Zhixiang Wang, Kaifan Niu, Wei Liu, Xinyun Wang, Boshen Yang, Taixi Li, Yizhi Chen, Yuanyuan Jin, Yu Chen, Yangyi Lin, Xian Jin   +10 more
wiley   +1 more source