Results 31 to 40 of about 9,292,045 (246)
A business perspective of legacy systems [PDF]
, 1999 \ud Legacy information systems evolved incrementally in response to changes in business strategy and information technology. Organizations are now being forced to change much more radically and quickly than previously and this change places new demands ...
Holland, Christoper +3 more
core
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
An alternative theory of legacy information systems [PDF]
, 2003 Organisational dependence upon IT continues to grow yet experiences of satisfaction vary widely. Problematic, aged IT is often cited as being a fundamental problem in this respect and this is commonly termed legacy information systems.
Light, Ben
core +1 more source
Governance of the London 2012 Olympic Games legacy [PDF]
, 2011 © The Author(s) 2011. This is the author's accepted manuscript. The final published article is available from the link below.This study addresses the governance of the London 2012 Olympics legacy.
Vassil Girginov +2 more
core +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Comparison and analysis of methods for migrating legacy systems to SOA
MATEC Web of Conferences, 2016 Migration of legacy systems to SOA has caught lots of attention in both academic and industry. People have proposed many methods, such as wrapping, reengineering etc.
Liu Dong, Zhang Caihuan
doaj +1 more source
Journal of Telecommunications and Information Technology, 2003 This paper describes an ongoing effort at NC3A to provide one integrated database which contains data from a number of different sources. Initially, these sources are legacy NATO systems.
Jon Wilkes
doaj +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Recovery And Migration Of Application Logic From Legacy Systems
Computer Science, 2012 Future Internet technologies necessitate dramatic changes in system design, deliveryand usage patterns. For many legacy applications it means that their furtherdevelopment and transition to the Internet becomes problematic or evenimpossible due to the ...
Wiktor Nowakowski +4 more
doaj +1 more source