Results 121 to 130 of about 373,573 (310)
LEGAL ACTIVITY AS AN ELEMENT OF THE LEGAL SYSTEM: THEORETICAL AND LEGAL APPROACH
D. Tychyna, I. Hrytsiuk
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G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis
Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang +9 more
wiley +1 more source
FINANCIAL ACTIVITY AND LEGAL ACTIVITY: THEIR LEGAL ESSENCE
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LEGAL FORM OF ACTIVITY OF LEGAL ENTITIES OF CORPORATION TYPE
In Ukraine, entrepreneurship started forming in the absence of the previous experience of its legal regulation in connection with the long socialist period. The relationship between individuals and organisations that have merged in one corporation needs special regulation, and one of the means by which it became possible to regulate relations on the ...
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The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi +8 more
wiley +1 more source
Ethical aspect of the legal regulation of police officers' activities
The article theoretically analyses the importance of professional ethics in the legal regulation of the activities of a police officer. The topic of the approach to the legal regulation of the activities of an officer is insufficiently discussed ...
Aleknavičiūtė, Ingrida +1 more
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ABSTRACT Self‐healing materials represent a paradigm shift in designing functional biomedical devices for drug delivery, tissue regeneration, and 3D bioprinting. However, their clinical translation remains limited by challenges such as insufficient mechanical strength, potential cytotoxicity from chemical modifications, and complex activation ...
Ganjun Feng +15 more
wiley +1 more source
Metacognitive Strategies in Text-Based Activities (for legal texts)
Globalization on the one hand and border closure on the other hand spur communication process participants in all areas of human activities and especially young researchers into foreign language learning which is currently focused on foreign ...
Veronika V. Makhova, Oksana N. Zanina
doaj +1 more source
Targeting Supramolecular Active Complexes of Nav1.7/Nav1.8 to Relieve Chronic Neuropathic Pain
In mice and patients with severe chronic neuropathic pain (NP), Nav1.7, Nav1.8, TrkB, and five cytoskeletal proteins form supramolecular active complexes (SMACs) with polygonal lattice structures as noxious signal amplifiers in dorsal root ganglion (DRG) neurons.
Liting Sun +27 more
wiley +1 more source
A Proposal for Funding Legal Services
Connecticut may have found a way of transforming the baser elements into gold. At least, that seems to be the effect of a bill that the State Treasurer has prepared for introduction in the 1973 session of the General Assembly. The bill, which is designed
Roitman, Howard
core

