Results 41 to 50 of about 191,416 (264)

Gm26550 Modulates Learning and Memory by Increasing IGF1 mRNA Expression and Stability in Nrf2−/− Mice

Advanced Science, EarlyView.
The present study shows that Nrf2 directly binds to the Gm26550 promoter, thereby activating Gm26550 transcription and increasing its expression. Mechanistically, Gm26550 promotes IGF1 expression by functionally antagonizing miR‐26a‐5p‐mediated repression and sequestering the RBP KHSRP, thereby enhancing hippocampal neuronal synaptic plasticity and ...
Hongfang Wang, Ziyao Wang, Dongyue Zuo, Zhaowen Su, Bowen Song, Jiamin Gao, Yizhou Zhang, Ruiting Zhao, Linjie Sun, Mengdi Li, Yirui Fan, Dandan Geng, Lei Wang   +12 more
wiley   +1 more source

Artificial intelligence in university practice: a systematic review of open access in Spain

Revista Digital de Investigación en Docencia Universitaria
Introduction: Artificial intelligence (AI), particularly generative AI such as ChatGPT, is influencing higher education by introducing opportunities for personalized learning and process automation.
Mariola Moreno, María del Pilar Blanco-Calvo, Katherine Gajardo-Espinoza   +2 more
doaj   +1 more source

Organoid Brain‐Machine‐Interface Devices for Central Nervous System Repair

Advanced Science, EarlyView.
We envision organoid brain‐machine‐interface (Organoid‐BMI) devices as new biohybrid bidirectional communication pathways to connect the human CNS and the external world for personalized CNS repair and regeneration. ABSTRACT Central nervous system (CNS) repair and regeneration suffer from tremendous clinical challenges due to current limitations in ...
Yantao Xing, Yang Yang, Zichen Hong, Chunhui Tian, Huiyu Chu, Susanne Clara Prokop, Hongwei Cai, Mingxia Gu, Jason Tchieu, Ken Mackie, Feng Guo   +10 more
wiley   +1 more source

Harnessing Intelligent GISs for Educational Innovation: A Bibliometric Analysis of Real-Time Data Models

Education Sciences
This study explores the potential of Intelligent Geographic Information Systems (GISs) in advancing educational practices through the integration of real-time data models.
Eloy López-Meneses, Irene-Magdalena Palomero-Ilardia, Noelia Pelícano-Piris, María-Belén Morales-Cevallos   +3 more
doaj   +1 more source

A Second Pathogenic Protein, PolyGN2C‐iso2, Reveals a Dual‐Protein Pathology in Neuronal Intranuclear Inclusion Disease

Advanced Science, EarlyView.
This study reveals that NOTCH2NLC transcript variant 2 generates PolyGN2C‐iso2, an aggregating protein present within intranuclear inclusions of NIID patient tissues. A novel mouse model expressing PolyGN2C‐iso2 recapitulates white matter abnormalities and cognitive deficits, mechanistically linked to mitochondrial dysfunction. These findings support a
Kang Zhang, Wenhao Ma, Yi Zhou, Zhijie Wu, Pan Gao, Hongze Niu, Hongfei Tai, Tianyi Zhao, Zheyue Dong, Li Li, Yan Zhang, An Wang, Si Shen, Yueyang Li, Sifei Yu, Yan Peng, Wang Sheng, Xiaoyan Dong, Hua Pan, Kaibin Shi, Magdalena J. Koziol, Xiaobing Wu, Zaiqiang Zhang   +22 more
wiley   +1 more source

Axiology of Legal Culture and the Boundaries of Legal Choice

Теоретическая и прикладная юриспруденция
Introduction. The article is devoted to the study of legal culture as an important aspect of the life of society and the state. The role of legal culture in the formation of legal reality is considered, approaches to the definition and composition of ...
D. G. Alova
doaj   +1 more source

Investigating the effect of the perpetrator's belief on the psychological element of murder from the perspective of Criminal Law of Iran, Afghanistan and Imamiyah Jurisprudence. [PDF]

مطالعات فقه اسلامی و مبانی حقوق
According to Iranian criminal law, Afghanistan and Imamieh jurisprudence are one of the conditions for the realization of murder that the perpetrator intended to murder a particular offender and achieved his goal.
ismail aghababaei bani, mahdi Taheri
doaj   +1 more source

Human Dental Pulp Stem Cell Secretome Restores Ischemic Stroke–Impaired Motor and Cognitive Functions by Reprogramming Redox and Inflammatory Signaling

Advanced Science, EarlyView.
Human dental pulp stem cell secretome emerges as a cell‐free therapeutic strategy for ischemic stroke by reprogramming redox and inflammatory signaling. hDPSC secretome‐derived antioxidant and immunomodulatory factors suppress the TLR4–NOX–ROS–NF‐κB axis, reduce microglial inflammatory responses and apoptosis, and promote neurogenesis, angiogenesis ...
Kyung‐Joo Seong, Sehoon Park, Sun‐Woong Bae, Daseul Kim, Jin Ho Lee, Won‐Seok Choi, Zee‐Yong Park, Ji‐Yeon Jung, Won‐Jae Kim   +8 more
wiley   +1 more source

Thinking Culture in Legal Education

Legal Education Review, 1996
Australia is a polyethnic society formed by the processes of colonisation and immigration. It has become a commonplace to say that we live in a “multicultural society”, yet contemporary Australia could more properly be characterised as “a society with a ...
Anthony O'Donnell
doaj   +1 more source

Legal consciousness and legal culture in the context of legal education of future pharmacists

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2017
One of the distinguishing features of man as a biological individual who is able to comprehend meaningfully the reality surrounding him and manage his actions is consciousness.
І. M. Alieksieieva
doaj   +1 more source