Results 21 to 30 of about 12,554,480 (305)

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Proactivity in legal education for Generations Z and Alpha: a case study

TalTech Journal of European Studies
As the world continues to evolve and transform, the challenge of actively engaging Generations Z and Alpha in the study of law has become apparent. Traditional teaching methods no longer capture the attention or commitment of these digital natives who ...
Restrepo Maria Paola Velásquez
doaj   +1 more source

Legal Protection of Sustainable Design in Colombia

La Propiedad Inmaterial, 2020
La configuración de productos está abandonando la lógica tradicional de la producción en masa, de la obsolescencia programada y de que la calidad no cuenta. Nos enfrentamos a un proceso de transformación que reconoce la necesidad de preservar el ambiente,
Brenda Salas P.
doaj   +1 more source

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

Legal design and access to justice: a case study on child support payments in Chile

TalTech Journal of European Studies
The Chilean family court system is facing a growing challenge with child support payment arrears, a situation that burdens judicial resources and severely affects families, especially those facing socioeconomic hardships.
Lillo Ricardo, Acevedo Patricia
doaj   +1 more source

O visual law como ferramenta de acessibilidade e concretização da integridade do direito

Cadernos Cajuína
Este trabalho analisa a crise do Acesso à Justiça, não como um problema de desconhecimento individual, mas como um colapso comunicacional e ético do sistema, que torna o Direito um "código hostil" para o cidadão.
Lucas Ribeiro Morelato, Almir Gallassi
doaj   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Desafíos de la era digital que influyen en la argumentación jurídica en el siglo XXI

Cadernos Cajuína
En el contexto de la transformación digital del Derecho, las tecnologías emergentes han impactado significativamente la construcción de la argumentación jurídica y los procesos de toma de decisiones en el ámbito judicial.
Rita de Cássia Dias de Faria
doaj   +1 more source

Reperfusion‐Dependent Outcomes After Endovascular Thrombectomy Stratified by NIHSS‐ASPECTS Clinical‐Core Mismatch

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This analysis evaluates the effect of successful reperfusion on functional outcomes after MT, stratified by admission National Institutes of Health Stroke Scale (NIHSS) and Alberta Stroke Program Early CT Score (ASPECTS) as surrogates for clinical‐core mismatch, using multicenter registry data.
Felix Schlicht, Lukas Meyer, Gabriel Broocks, Matthias Bechstein, Christian Thaler, Christian Heitkamp, Laurens Winkelmeier, Vincent Geest, Alexander Heitkamp, Maximilian Jungnitz, Gregor Peter, Luca Meucci, Tobias Faizy, Jawed Nawabi, Caspar Brekenfeld, Fabian Flottmann, Maximilian Schell, Alexandros Hadjilaou, Uta Hanning, Götz Thomalla, Jens Fiehler, Susanne Gellißen, Helge C. Kniep, for the German Stroke Registry Endovascular Treatment, (GSR‐ET) Alexander Nave, Anna Alegiani, Annerose Mengel, Arno Reich, Bernd Eckert, Charlotte Pietrock, Christian Nolte, Eberhard Siebert, Fabian Flottmann, Fee Keil, Franziska Dorn, Gabor Petzold, Götz Thomalla, Hanna Zimmermann, Jan Borggrefe, Jan Hendrik Schäfer, Jens Fiehler, Joachim Röther, Klaus Gröschel, Lars Kellert, Mario Abruscato, Maximilian Schell, Omid Nikoubashman, Peter Schellinger, Silke Wunderlich, Steffen Tiedt, Sven Thonke, Timo Uphaus, Tobias Boeckh‐Behrens, Ulrike Ernemann   +53 more
wiley   +1 more source

Mapping Meaningfulness: Stakeholder Engagement Models in Nordic Large-Cap Technology Firms

Baltic Journal of Law & Politics
This article examines how stakeholder engagement is structured and practiced in corporate sustainability disclosures of Nordic large cap technology firms listed on Nasdaq Nordic Stock Exchange and assesses the extent to which such engagement enables ...
Metin Ebru
doaj   +1 more source