Results 161 to 170 of about 727,903 (338)

Intellectual Property and Indigenous Peoples: Adapting Copyright Law to the Needs of a Global Community [PDF]

open access: yes, 2004
The definition and scope of intellectual property and associated laws are under intense debate in the emerging discourse surrounding intellectual property and human rights. These debates primarily arise within the context of indigenous peoples\u27 rights
Carpenter, Megan M.
core   +2 more sources

The FOXC2‐LAMA4 Axis Orchestrates Vasculogenic Mimicry and Immunosuppressive Niche Formation to Drive Metastatic Cascade in Renal Cell Carcinoma

open access: yesAdvanced Science, EarlyView.
Advanced clear cell renal cell carcinoma metastasis is driven by a FOXC2+ tumor subpopulation. These cells execute vasculogenic mimicry for dissemination and secrete LAMA4. LAMA4 engages macrophage ITGA6, activating the STAT6/GATA3 axis to polarize macrophages into a pro‐metastatic, immunosuppressive phenotype.
Jiaxi Yao   +11 more
wiley   +1 more source

Targeting the GPX4–FUNDC1 Interaction with Magnesium Lithospermate B Attenuates Sepsis‐Associated Lung Injury

open access: yesAdvanced Science, EarlyView.
The diagram depicts the endothelial‐protective mechanism of magnesium lithospermate B (MLB) in sepsis‐associated lung injury. MLB binds GPX4 at Gly79, disrupts its interaction with FUNDC1, prevents mitophagy‐mediated GPX4 degradation, restores mitophagic flux, reduces ROS, and limits ferroptosis.
Zhixi Li   +10 more
wiley   +1 more source

Legal Rhetoric in American Political Speeches: A Qualitative Analysis of Persuasion, Governance, and Constitutional Discourse [PDF]

open access: yesScientific Bulletin of the Politehnica University of Timişoara: Transactions on Modern Languages
Legal rhetoric is a powerful tool in American political discourse, shaping public perception, policy justification, and judicial influence. This qualitative case study examines how U.S.
Maria-Magdalena LĂPĂDAT
doaj  

Integrated Microfluidic Platform for High‐Throughput Generation of Intestinal Organoids in Hydrogel Droplets

open access: yesAdvanced Science, EarlyView.
ABSTRACT Organoid research offers valuable insights into human biology and disease, but reproducibility and scalability remain significant challenges, particularly for epithelial organoids. Here, we present an integrated microfluidic platform that addresses these limitations by enabling high‐throughput generation of uniform hydrogel microparticles ...
Barbora Lavickova   +8 more
wiley   +1 more source

Respuestas Judiciales a la Violencia de Género: el Derecho como Discurso y Práctica Sociales (Judicial Responses to Gender-based Violence: The Law as Discourse and Social Practice)

open access: yesOñati Socio-Legal Series, 2015
Usually the studies on the legal system are limited to normative or jurisprudential analysis. However, long time ago, we know that to understand to the law needs to know its meanings, its previous values and also its speeches and practices; this is, to ...
Mariana N. Sánchez Busso
doaj  

Discourses on Violence in Costa Rica, El Salvador, and Nicaragua: Laws and the Construction of Drug- and Gender-Related Violence [PDF]

open access: yes
In Central America, legislation aiming to reduce violence and crime has become an important topic in the security debate. Focusing on Costa Rica, El Salvador, and Nicaragua, this paper analyzes laws and other legal texts regarding the trade in and ...
Peter Peetz
core  

Spatially Resolved Multiomics Reveals Metabolic Remodeling and Autophagy Activation in Adamantinomatous Craniopharyngiomas

open access: yesAdvanced Science, EarlyView.
Multiomics integration analysis reveals the “cystic fluid–tumor cell” metabolic coupling that mediates active choline/ethanolamine uptake of tumor cells from cystic fluid and PC/PE synthesis pathways reprogramming that mediating autophagy pathway activation within ACP. ABSTRACT Adamantinomatous craniopharyngioma (ACP), a benign yet highly recurrent and
Dongting Chen   +9 more
wiley   +1 more source

Respuestas Judiciales a la Violencia de Género: el Derecho como Discurso y Práctica Sociales (Judicial Responses to Gender-based Violence: The Law as Discourse and Social Practice)

open access: yesOñati Socio-Legal Series, 2014
Usually the studies on the legal system are limited to normative or jurisprudential analysis. However, long time ago, we know that to understand to the law needs to know its meanings, its previous values and also its speeches and practices; this is, to ...
Mariana N. Sánchez Busso
doaj  

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