Results 71 to 80 of about 364,720 (262)
Advanced Science, EarlyView.Integrative multi‐cohort analyses identify 14‐3‐3γ as a biomarker and regulator of cognitive vulnerability. Experimental studies show that 14‐3‐3γ loss is associated with Tau Thr205 phosphorylation, synaptic dysfunction, and cognitive impairment, while genetic overexpression or pharmacological stabilization of 14‐3‐3γ confers protective effects in ...
Shouqiang Zhu +5 more
wiley +1 more source
The will and the family: Psychiatric and legal perspectives [PDF]
Paediatrics & Child Health, 2001 G, Schneiderman, F C, Kirsh
openaire +2 more sources
Single‐Cell Profiling Reveals Clonally Expanded CX3CR1+ T Cells in Anti‐NMDA Receptor Encephalitis
Advanced Science, EarlyView.CX3CR1+ T cells are associated with peripheral and central immune alterations in anti‐NMDA receptor encephalitis (NMDAR‐E). They show potential responsiveness to GluN1 (NR1) peptides, potential interactions with peripheral B cells, clonal expansion, increased CD137/CD154 expression, and inflammatory cytokine production. Their preferential cerebrospinal
Lin Yan +13 more
wiley +1 more source
Advanced Science, EarlyView.High‐throughput Differential Dynamic Microscopy measures frequency‐resolved mechanical fingerprints from 3 to 10 μL$\umu{\rm L}$ mucus samples using only a few minutes of operator attention per sample. This automated analysis enables scalable mucus phenotyping for translational research by distinguishing mechanical heterogeneity among donors, disease ...
Feng Ling +18 more
wiley +1 more source
Zeszyty PrawniczeThis article examines the legal complexities surrounding patchwork families, focusing on the rights of children within such structures. A patchwork family, defined as a family formed by the remarriage or cohabitation of one or both parents with new ...
Dariusz Skłodowski
doaj +1 more source
Advanced Science, EarlyView.Bilateral temporal accelerated 40‐Hz tACS improves cognitive function in patients with Alzheimer's disease. Resting‐state fNIRS identifies treatment‐related increases in frontotemporoparietal functional connectivity, which are associated with cognitive improvement. ABSTRACT The temporal lobes are key hubs for memory and cognition.
Rong Guo +10 more
wiley +1 more source
Advanced Science, EarlyView.LAPTM5 functions as a critical molecular scaffold bridging PGAM5 and VAMP to facilitate PGAM5‐mediated dephosphorylation of VAMP8. This cascade promotes autophagosome‐lysosome fusion, restores impaired autophagic flux, and clears damaged mitochondria, thereby mitigating cellular oxidative stress and systemic inflammation.
Lang Jiang +12 more
wiley +1 more source
Drug Repurposing for Treating NCOR‐Related Intellectual Disability
Advanced Science, EarlyView.An autism‐associated NCOR1 heterozygous mutation upregulates NRGs and activates NRG backward signaling in hypothalamic GABAergic neurons in mouse models, leading to Gabra2 downregulation and cognitive deficits, which can be therapeutically targeted by repurposing FDA‐approved drugs.
Yan Kong +15 more
wiley +1 more source
FAMILY - CONSTITUTIONAL, LEGAL, SOCIAL AND HUMAN PERSPECTIVE [PDF]
Challenges of the Knowledge Society, 2019 The idea of family represents a concept almost as old as law. The sense that we give to family is oscillating between legal definitions and social and human concepts.
Marta-Claudia CLIZA +1 more
doaj
How Video‐Based Information Affects Farmers' Willingness to Pay for Drone Services
Applied Economic Perspectives and Policy, EarlyView.ABSTRACT Professional service for digital technology like agricultural drones lowers transaction costs and scope thresholds for smallholders. Meanwhile, perceptual adoption barriers remain underexplored. We conduct a two‐stage choice experiment with a randomized video‐based information treatment among 384 Chinese crop farmers to measure its effect on ...
Hua Zhang +4 more
wiley +1 more source