Results 81 to 90 of about 353,187 (260)

Deconstruction of Human Age‐Related Cataract Capsules Defines Aging

Advanced Science, EarlyView.
We generate a comprehensive atlas of age‐related cataracts (ARC) at a single‐cell resolution, encompassing three disease states—mild cataract group (Mild), severe cortical cataract group (Severe_C), and severe nuclear cataract group (Severe_N). We find that ARC involves seven distinct lens capsule cell types, with notable differences in cellular ...
Qiaomei Tang, Ziyang Tong, Chunmei Fan, Silong Chen, Jiarui Guo, Jianghua Hu, Ke Yao, Zi Yin, Xiao Chen, Yibo Yu   +9 more
wiley   +1 more source

LEGAL ISSUES RELATING TO PATCHWORK FAMILIES: A NORMATIVE ANALYSIS AND THE LEGAL STATUS OF THE CHILDREN

Zeszyty Prawnicze
This article examines the legal complexities surrounding patchwork families, focusing on the rights of children within such structures. A patchwork family, defined as a family formed by the remarriage or cohabitation of one or both parents with new ...
Dariusz Skłodowski
doaj   +1 more source

An Australian hospital's training program and referral pathway within a multi‐disciplinary health–justice partnership addressing family violence

Australian and New Zealand Journal of Public Health, 2018
Objective: An innovative health–justice partnership was established to deliver legal assistance to women experiencing family violence who attended an Australian hospital.
Kirsty Forsdike, Cathy Humphreys, Kristin Diemer, Stuart Ross, Linda Gyorki, Helena Maher, Penelope Vye, Fleur Llewelyn, Kelsey Hegarty   +8 more
doaj   +1 more source

The right to family and community life of children and adolescents: historical building in Brazil

Serviço Social em Revista, 2017
The work is a theoretical study on the legal construction of the right to family and community life of children and adolescents. Current law recognizes that the family is the privileged place for the development of children and adolescents, subject to ...
Antônia Gomes Furtado, Klênia Souza Barbosa de Morais, Raffaella Canini   +2 more
doaj   +1 more source

A Second Pathogenic Protein, PolyGN2C‐iso2, Reveals a Dual‐Protein Pathology in Neuronal Intranuclear Inclusion Disease

Advanced Science, EarlyView.
This study reveals that NOTCH2NLC transcript variant 2 generates PolyGN2C‐iso2, an aggregating protein present within intranuclear inclusions of NIID patient tissues. A novel mouse model expressing PolyGN2C‐iso2 recapitulates white matter abnormalities and cognitive deficits, mechanistically linked to mitochondrial dysfunction. These findings support a
Kang Zhang, Wenhao Ma, Yi Zhou, Zhijie Wu, Pan Gao, Hongze Niu, Hongfei Tai, Tianyi Zhao, Zheyue Dong, Li Li, Yan Zhang, An Wang, Si Shen, Yueyang Li, Sifei Yu, Yan Peng, Wang Sheng, Xiaoyan Dong, Hua Pan, Kaibin Shi, Magdalena J. Koziol, Xiaobing Wu, Zaiqiang Zhang   +22 more
wiley   +1 more source

Aberrant GRP78 Phase Transition Sustains Endothelial IRE1α Signaling and Drives Blood–Brain Barrier Failure in Cerebral Amyloid Angiopathy

Advanced Science, EarlyView.
Vascular Aβ40 corrupts GRP78 phase behavior in brain endothelial cells, sustaining IRE1α–TRAF2–JNK signaling and driving apoptosis, tight junction loss, and blood–brain barrier failure in cerebral amyloid angiopathy. Pharmacological IRE1α inhibition restores vascular integrity, reduces leakage, and improves functional outcomes, revealing a targetable ...
Honglin Zheng, Qiang Li, Haiyang Luo, Yapei Yuan, Na Zhang, Yongting Lu, Suying Duan, Jieshi Zhong, Hang Zhang, Chenyang Liu, Yaochong Zhang, Wenzhuo Zhao, Yaxuan Song, Tuo Wang, Si Yan, Yapeng Li, Han Liu, Yuan Gao, Zongping Xia, Yuming Xu   +19 more
wiley   +1 more source

EDNRA Forms a Positive Feedback Loop with the Hippo/YAP Axis to Drive Triple‐Negative Breast Cancer Progression

Advanced Science, EarlyView.
Endothelin receptor type A (EDNRA) and the Hippo/YAP pathway form a self‐reinforcing loop that sustains triple‐negative breast cancer. EDNRA activates YAP through Gαq/11–Rho/ROCK–LATS signaling, while YAP/TEAD4 reciprocally drives EDNRA transcription.
Zehao Hong, Boyang Li, Jiahui Xu, Ruonan Lin, Jinghao Pan, Chenlu Fang, Boxiang Zhang, Lucy Yue Lau, Richard J. Aldridge, Elizabeth A. Whitmore, Yi Chen   +10 more
wiley   +1 more source

FAMILY - CONSTITUTIONAL, LEGAL, SOCIAL AND HUMAN PERSPECTIVE [PDF]

Challenges of the Knowledge Society, 2019
The idea of family represents a concept almost as old as law. The sense that we give to family is oscillating between legal definitions and social and human concepts.
Marta-Claudia CLIZA, Laura-Cristiana SPĂTARU-NEGURĂ   +1 more
doaj  

Transcription Factor HOXC11 Drives Colorectal Cancer Progression and Metastasis via CAMK2A‐Dependent CXCL5 Upregulation

Advanced Science, EarlyView.
HOXC11 drives colorectal cancer progression by transcriptionally activating CAMK2A, which triggers NF‐κB–dependent CXCL5 upregulation. CXCL5–CXCR2 signaling further reinforces HOXC11 expression through the ERK1/2–SP1 axis, forming a prometastatic positive feedback loop that is effectively disrupted by combined CAMK2A and CXCR2 inhibition.
Qingyang Sun, Hengjie Xu, Sheng Yang, Jiahui Zhou, Chuanxin Tian, Hongxu Nie, Chi Jin, Tuo Wang, Zhihao Chen, Junwei Tang, Yifei Feng, Xiaowei Wang, Yueming Sun   +12 more
wiley   +1 more source

The Question of Family Law After Legal Motherhood

LSE Public Policy Review
What does it mean to be a ‘mother’ in law? This is a question that arose in English and Welsh law only relatively recently, in a case brought by Freddy McConnell, a trans man who had given birth and sought to be registered on the baby’s birth ...
Sarah Trotter
doaj   +2 more sources