Results 91 to 100 of about 109,164 (291)

G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis

open access: yesAdvanced Science, EarlyView.
Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang   +9 more
wiley   +1 more source

Under reporting of child sexual abuse- The barriers guarding the silence

open access: yesTelangana Journal of Psychiatry, 2018
Under-reporting of Child Sexual Abuse (CSA) is rampant in India, despite which India has the highest number of CSA cases in the world, the ramifications of which are enormous. Other than the obvious reasons of stigma and fear of the perpetrator, multiple
Suhas Chandran   +2 more
doaj   +1 more source

The Convicted Felon as a Guardian: Considering the Alternatives of Potential Guardians with Less-Than-Perfect Records

open access: yes, 2006
Courts require discretion in appointing guardians. Oftentimes, the legislature prevents the courts from exercising discretion when statutes are enacted that prohibit felons from serving as guardians under any circumstances.
Jorgensen, Mike
core  

TSPYL5 Promotes Triple‐Negative Breast Cancer Metastasis by Antagonizing USP10‐Mediated PTEN Stabilization to Unleash a ZEB1‐Dependent EMT Program

open access: yesAdvanced Science, EarlyView.
The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi   +8 more
wiley   +1 more source

"It must be the heart in the bottom" : A qualitative study of how legal guardians for unaccompanied children presents themselves and their role

open access: yes, 2018
Sweden is one of the countries in Europe that has received the highest number of unaccompanied children. Every unaccompanied children who comes to Sweden should get a legal guardian who is responsible for the children’s personal, economic and legal ...
Suncevska, Sandra
core   +1 more source

Schooling Trajectories and the Development of Brain Dynamics: A Comparative Study of Montessori and Traditional Education

open access: yesAdvanced Science, EarlyView.
We investigate whether Montessori and traditional schooling systems shape the developmental trajectory of large‐scale brain dynamics in different ways. We quantify the arrow of time (“non‐reversibility”) in neural activity during resting state and movie‐watching, revealing distinct maturational patterns.
Elvira del Agua   +6 more
wiley   +1 more source

Guardians: A Research Note

open access: yes, 1996
Guardianship is among the least-noticed, least-discussed institutions of the working legal system. For the most part, guardianship is an arrangement that concerns minors who come into a bit of property, or (at times) a lot of it.
Grossman, Joanna L.   +2 more
core   +2 more sources

Legal Protection of Minors Whose Land Certificates are Used as Collateral for Debts

open access: yesJurnal USM Law Review
This study aims to analyze the legal consequences of minors' land certificates used as debt collateral by their biological mothers and legal protection for minors whose land rights are used as debt collateral by their biological mothers.
Maxe Hidayat   +2 more
doaj   +1 more source

Integrated Single‐Cell and Spatial Analysis Reveals a Metabolic‐Immune Axis Driving Aortic Dissection

open access: yesAdvanced Science, EarlyView.
Single‐cell and spatial profiling of 110 human thoracic aortic samples reveals a stromal–immune circuit driving aortic dissection. An elastin‐rich fibroblast subset is depleted with age and markedly reduced in disease, weakening aortic wall integrity.
Jing Tao   +25 more
wiley   +1 more source

FEATURES OF REAL ESTATE TRANSACTIONS BY GUARDIANS OF A MINOR [PDF]

open access: yesLegal Bulletin
The article is devoted to the features and modern problems of implementing the rights of minors when concluding real estate transactions. Despite the fact that ensuring legal guarantees for minors when making transactions with their property is one of ...
VERKHOVA D.V.
doaj   +1 more source

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