Results 41 to 50 of about 443,531 (312)

Concepts and types of administrative and legal means of ensuring economic security by the National Police of Ukraine

open access: yesBulletin of Kharkiv National University of Internal Affairs, 2018
The author of the article has analyzed the existing doctrinal provisions concerning the definition of the terms “a method”, “a measure”, “a way” and “a mean” and the categories of “legal means”, “administrative and legal means”.
V. V. Tolochko
doaj   +1 more source

A critique of the technical and structural flaws in the legal aid scheme: and an analysis of the proposals for reform contained in the legal aid act 1988 [PDF]

open access: yes, 1989
The critique of the Legal Aid scheme is on two levels. Firstly ‘technical’ problems are discussed. It is in the nature of these problems that they can be resolved within the present structural arrangement of the scheme.
Stothard, David Ian
core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

Klasterisasi Peraturan Daerah di Seluruh Wilayah Jawa dengan Menggunakan Algoritma K-means

open access: yesJurnal Sisfokom, 2020
The Local Indonesian government generates various legal products. This study aims to cluster the titles of regional regulations in Java. The data are collected from law repositories of all provincial governments in Java. The repository is called as JDIH.
Nur Aini Rakhmawati   +4 more
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

MEANS AND METHODS OF LEGAL REGULATION

open access: yesLaw and modern states, 2014
The article discusses a method of legal regulation as a set of ways to influence the subjects of public relations. The article considers circumstances, predetermining the method of legal regulation of: the goals and objectives set by the state, uttering certain legal rules; features of the subjects of legal relations; the nature and the relationship of
openaire   +2 more sources

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

open access: yesFEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik   +6 more
wiley   +1 more source

STIMULATING AND LIMITING MEANS OF FORMATION AND REALIZATION OF LAW ENFORCEMENT POLICY

open access: yesСовременная наука и инновации, 2022
The article examines the theoretical and practical combination problems of stimulating and limiting means of law enforcement policy formation and realization; analyses different points of view about effective ways of public development management in the ...
Margarita Hamletovna Arutjunova
doaj  

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi   +2 more
wiley   +1 more source

CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang   +6 more
wiley   +1 more source

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