Results 51 to 60 of about 7,585,900 (302)

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

FINANCIAL AND LEGAL NORMS: LEGAL MEANS AND MECHANISM OF IMPLEMENTATION

open access: yesBaltic Journal of Economic Studies, 2018
The aim of the article is to disclose problematic issues, which are connected with financial and legal norms, as well as legal means and the mechanism for their implementation.
Mykhailo Pitiulych   +2 more
doaj   +1 more source

The legal meaning of death.

open access: yesAmerican Journal of Public Health and the Nations Health, 1968
THE recent human-to-human heart transplants in widely separated parts of the world have exploded public interest and concern in many very fundamental issues of life and of death. Many of these issues have been evident in earlier transplant surgery and other medical-biological advances.' However, it took the transplant of the heart, with all of the ...
openaire   +3 more sources

Revisiting the Contribution of Literal Meaning to Legal Meaning [PDF]

open access: yesOxford Journal of Legal Studies, 2009
Many theorists take the view that literal meaning can be one of a number of factors to be weighed in reaching a legal interpretation. Still others regard literal meaning as having the potential to legally justify a particular outcome. Building on the scholarly response to HLA Hart’s famous ‘vehicles in the park’ hypothetical, this article presents ...
openaire   +2 more sources

Cell surface CD11c as a neutrophil aging marker molecule

open access: yesFEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki   +5 more
wiley   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu   +21 more
wiley   +1 more source

DUALITY OF THE LEGAL NORMS SANCTIONS: CONCEPTUAL BASES

open access: yesRussian Journal of Economics and Law, 2011
The theme's topicality is conditioned by the fact that the legal norm sanction expresses some essential features of law, which gives way to new directions of sanctions study.
A. V. Krasnov
doaj  

Categories “Mechanism of Legal Regulation” and “Legal Technology”

open access: yesСибирское юридическое обозрение, 2020
The article analyzes the legal means that are elements of both the mechanism of legal regulation and legal technology, their characteristics are given, its purpose is indicated.
I. N. Senin
doaj   +1 more source

Comprehensive Assessment of Arterial, Tissue, and Venous Collaterals for Evaluating the Infarct Growth Rate: The Multimodal Collateral Score

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Collaterals are crucial factors that influence the infarct growth rate (IGR). We aimed to determine whether a comprehensive multimodal collateral score (MCS), incorporating collateral assessment at the arterial, tissue, and venous levels, is associated with functional independence and provides incremental prognostic value over ...
Giorgio Busto   +12 more
wiley   +1 more source

Specifics of Legal Effect Mechanism

open access: yesУченые записки Казанского университета: Серия Гуманитарные науки, 2017
The importance of studying law as one of the most efficient means of social control and regulation has been raised in the paper. Solving this problem requires understanding the mechanism by which law influences society and people. The aim of the study is
E.K. Shcherbakova
doaj  

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