Results 31 to 40 of about 3,356,126 (305)

Law & Economics as a Theory of Decision Making in Legal Contexts – Decision Theoretical Foundations, Their Misinterpretations and Excessive Claims of Economic Analysis of Law [PDF]

open access: yesArchiwum Filozofii Prawa i Filozofii Społecznej, 2012
The article treats law & economics as a proposal of a theory of decision making in legal settings. It is emphasized that the distinction between two approaches in economic analysis of law: the neoclassical and the behavioral one, is made with reference ...
Magdalena Małecka
doaj   +1 more source

Comparative Drug Response Profiling in Neuroblastoma Cell Lines and Patient‐Derived Tumor Organoids

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT High‐risk neuroblastoma remains a leading cause of pediatric cancer mortality, and improved preclinical models are needed to guide therapeutic developments. We screened seven high‐risk neuroblastoma cell lines and three patient‐derived tumor organoids with 528 compounds alongside bone marrow controls, and compared them with external datasets ...
Krzysztof Wierbiłowicz   +12 more
wiley   +1 more source

Feeding, Fear, and Acceptance: Caregivers’ Experiences of Nutritional Support During Childhood Cancer Treatment

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose To explore caregivers' experiences and perceptions of the nutritional challenges faced by children and adolescents undergoing cancer treatment, including oral intake and the use of nutritional support. Methods This was a qualitative study based on focus groups with parents and caregivers at a Brazilian pediatric oncology hospital ...
Danyelle Apparecida Balsamão Marques   +5 more
wiley   +1 more source

Moral Norms and the System of Legal Norms. Legal Ethics

open access: yes, 2020
ABSTRACT: For a long time, after the appearance of man on Earth, the human being lived in disorder, relying only on animal instincts, strictly satisfying his primary needs for food, shelter and reproduction. Evolution, however, forced him to adopt another way of life, the social one, settling and grouping in systems of administrative organization ...
openaire   +1 more source

Legal normativity as a moral property [PDF]

open access: yesRevus, 2019
This paper comments on Brian Bix’s article “Kelsen, Hart, and Legal Normativity”. It provides some remarks regarding the concept of normativity and subscribes to the idea that it should not be reduced to an empirical nor a moral property. The discussion is primarily focused on the current, post-Hartian thesis that reduces legal normativity to moral ...
openaire   +3 more sources

About logical value of legal norm [PDF]

open access: yes, 2011
The article discusses metalogical issues taking up in jurisprudence and putting a question connected to logical value of legal norms and logical value of the other statements in normative discourse.
Bekrycht, Tomasz
core  

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

Cell surface CD11c as a neutrophil aging marker molecule

open access: yesFEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki   +5 more
wiley   +1 more source

Norm and Numerical Radius Inequalities for a Product of Two Linear Operators in Hilbert Spaces [PDF]

open access: yes, 2006
The main aim of the present paper is to establish some norm and numerical radius inequalities for the composite operator BA under suitable assumptions for the transform Cα ,β (T) := (T∗ −α I)(β I−T) , where α ,β ∈ C and T ∈ B(H), of the operators ...
S. S. Dragomir   +2 more
core   +2 more sources

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu   +21 more
wiley   +1 more source

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