Results 41 to 50 of about 3,356,126 (305)

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit   +11 more
wiley   +1 more source

Problematyka gałęziowości norm prawnych na przykładzie poszukiwania kryteriów wyodrębniania prawa administracyjnego

open access: yesStudia i Materiały, 2016
The study contains a critical analysis of contemporary issues of branches of legal norms. In this article we can find clearly critical opinions concerning recent attempts in the Polish literature on the science of law to distinguish criteria of ...
Michał Możdżeń-Marcinkowski
doaj   +1 more source

The Legal Argument and the Declaration of Guilt

open access: yesRevista Facultad de Jurisprudencia, 2018
The legal argument constitutes a category of undeniable value in the contemporary legal systems. The use of an ample legal literature, the use of relevant rules and an adequate evidence assessment, provide the judge with objective evaluation criteria ...
Esteban Alejandro Guamán Ramos
doaj   +1 more source

Onasemnogene Abeparvovec in Patients With SMA: Interim Results of the RESTORE Registry in Japan

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective There are limited real‐world data regarding the safety and effectiveness of onasemnogene abeparvovec (OA; Zolgensma) infusion, a one‐time gene replacement therapy, for Japanese patients with spinal muscular atrophy (SMA). We aimed to improve understanding of the real‐world outcomes for OA in Japan.
Kayoko Saito   +8 more
wiley   +1 more source

LEGAL NORM AS COMMAND

open access: yesStrani pravni život, 2010
During the long history of legal theory legal norms were often construed as commands. This gave rise to the so-called command theory of law propounded not only be legal positivists but also by adherents of natural law.
Dušan Vranjanac
doaj  

Correlation of financially-legal law and financial legal relationship

open access: yesТеорія і практика правознавства, 2016
The specific of financial legal relationship is analysed, the features of correlation of financial legal relationship and financially-legal norm are marked as his ...
Г. В. Россіхіна
doaj   +1 more source

Effects of Add‐On Icosapent Ethyl With Standard Treatment on Functional Outcomes and Inflammatory Biomarkers in Acute Ischemic Stroke: A Blinded Randomized Controlled Trial

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Ischemic stroke, a major cause of mortality and long‐term disability, results from the abrupt cessation of cerebral blood flow due to vascular occlusion or rupture. Icosapent Ethyl (EPA‐EE), approved for hypertriglyceridemia, has anti‐inflammatory and antithrombotic properties that may lessen ischemic damage.
Mitra Mahmoudi Meymand   +5 more
wiley   +1 more source

Validity as Bindingness: The Normativity of Legality [PDF]

open access: yesSSRN Electronic Journal, 2006
I shall argue that the concept of (valid) law is a purely normative notion, irreducible to any factual description. This uncontroversial notion, which is shared by all approaching the law from the internal point of view, needs to be distinguished from the competing theories on the grounds of legal bindingness, namely, on the reasons for qualifying a ...
openaire   +2 more sources

Bi‐ and Mono‐Allelic RFC1 Expansion in a North American Cohort With Idiopathic Axonal Neuropathy

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective RFC1 biallelic repeat expansion is increasingly recognized as a cause of chronic idiopathic axonal polyneuropathy (CIAP), but it remains challenging to know who to test. This study aims to determine the prevalence of biallelic and monoallelic RFC1 expansions and their corresponding neuropathy phenotypes in CIAP patients and identify ...
Amro M. Stino   +25 more
wiley   +1 more source

Nekrodiatagma. Some Observations on I. Thrake Aeg. E216

open access: yesPrávněhistorické studie
The paper analyzes a funerary inscription from Maroneia, which contains an uncommon legal term – νεκροδιάταγμα. After a brief prosopographic and textual analysis of the inscription, the paper examines the term νεκροδιάταγμα from the point of view of the ...
Lyuba Radulova
doaj   +1 more source

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