Results 31 to 40 of about 3,209,823 (291)

Ontology Building of Manufacturing Quality Knowledge for Design Decision Support [PDF]

open access: yes, 2010
This work was funded by National Natural Science Foundation of China (No: 70472066, 70771091), the project of Bureau of Science, Technology and Industry for National Defence, China (No. Z142008A001), the NPU Foundation for Humanities, Social Science, and
EYNARD, Benoit   +4 more
core  

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit   +11 more
wiley   +1 more source

DIKWP-Guided Semantic Modeling of Intellectual Property Reasoning for Explainable Legal AI

open access: yesApplied Sciences
Intellectual property reasoning depends on the interaction of factual context, doctrinal tests, exceptions, evidentiary uncertainty, and regulatory objectives.
Zhendong Guo, Yucong Duan
doaj   +1 more source

A Semantic Retrieval System for Case Law

open access: yesApplied Computer Systems, 2019
Legal reasoning, the core of legal practice in many countries, is “stare decisis” and its soundness is usually strengthened by relevant case law consulted.
Ebietomere Esingbemi Princewill   +1 more
doaj   +1 more source

ZER1 Restrains Pressure Overload‐Induced Cardiac Remodeling by Targeting DVL2 for Gly/N‐Degron‐Dependent Degradation

open access: yesAdvanced Science, EarlyView.
Pressure overload suppresses cardiomyocyte ZER1, weakening CRL2Zer1‐mediated DVL2 degradation and allowing DVL2 accumulation. Elevated DVL2 activates CaMKII‐HDAC4‐MEF2C signaling, drives fetal gene reactivation, and promotes pathological remodeling.
Mingchao Jiang   +27 more
wiley   +1 more source

Posthuman Feminism’s Diagnostics and Horizons for International Law: Review Essay on Emily Jones’ Feminist Theory and International Law: Posthuman Perspectives

open access: yesFilozofia
This review essay critically examines Emily Jones’ Feminist Theory and International Law: Posthuman Perspectives, which develops “posthuman feminism” to diagnose the exclusionary humanism and anthropocentrism of international law.
Shisong Jiang
doaj   +1 more source

Deconstruction of Human Age‐Related Cataract Capsules Defines Aging

open access: yesAdvanced Science, EarlyView.
We generate a comprehensive atlas of age‐related cataracts (ARC) at a single‐cell resolution, encompassing three disease states—mild cataract group (Mild), severe cortical cataract group (Severe_C), and severe nuclear cataract group (Severe_N). We find that ARC involves seven distinct lens capsule cell types, with notable differences in cellular ...
Qiaomei Tang   +9 more
wiley   +1 more source

Legal Education as a Significant Part of Law's Social Ontology

open access: yesCognitio, 2019
Touching upon issues such as lawyers’ critical competences, the adequacy of law schools’ professional training or the way legal students relate to civic engagement, this paper will present the research activities of the Centre for Legal Education and ...
Alexandra Mercescu, Mical Stambulski
doaj   +1 more source

A Second Pathogenic Protein, PolyGN2C‐iso2, Reveals a Dual‐Protein Pathology in Neuronal Intranuclear Inclusion Disease

open access: yesAdvanced Science, EarlyView.
This study reveals that NOTCH2NLC transcript variant 2 generates PolyGN2C‐iso2, an aggregating protein present within intranuclear inclusions of NIID patient tissues. A novel mouse model expressing PolyGN2C‐iso2 recapitulates white matter abnormalities and cognitive deficits, mechanistically linked to mitochondrial dysfunction. These findings support a
Kang Zhang   +22 more
wiley   +1 more source

OntoPriv: Towards Designing a DPV-based Legal Ontology for Knowledge Retrieval and Compliance in Privacy Legislation

open access: yesCLEI Electronic Journal
In an increasingly digital world, protecting personal data has become a pressing global issue, prompting the creation of complex regulations aimed at safeguarding individuals' privacy.
Gabriela Suntaxi   +5 more
doaj   +1 more source

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