Results 71 to 80 of about 1,659,673 (341)

Morphological and Hyperphosphorylation Transitions of Nanoscale Tau Aggregates in Alzheimer's Disease

open access: yesAdvanced Science, EarlyView.
Super‐resolution microscopy identifies nano‐sized tau aggregates (nano‐aggregates) and reveals distinct transitions in their morphology and phosphorylation profiles across control, Primary Age‐Related Tauopathy, and Alzheimer's disease brains. Morphology and hyperphosphorylation signatures distinguish physiological from pathological forms, with nano ...
Adriana N. Santiago‐Ruiz   +5 more
wiley   +1 more source

Alf Ross and his legal philosophy

open access: yesBratislava Law Review, 2018
The article has the ambition to present basic information of Alf Ross’s legal philosophy, focusing on his understanding of validity of law, concept of rights, coercion in law, as well as the purpose of the legal science from his point of view as a ...
Olexij Meteňkanyč
doaj   +1 more source

A Virtual Clinical Trial of Psychedelics to Treat Patients With Disorders of Consciousness

open access: yesAdvanced Science, EarlyView.
Disorders of consciousness after severe brain injury are marked by reduced complexity of brain activity and limited treatment options. Using personalized whole‐brain models, this study shows that simulated lysergic acid diethylamide (LSD) and psilocybin shift patient brain dynamics closer to criticality.
Naji L.N. Alnagger   +17 more
wiley   +1 more source

Formalism and Realism in Ruins (Mapping the Logics of Collapse)

open access: yesТеоретическая и прикладная юриспруденция
After laying out a conventional account of the formalism vs. realism debates, this Article argues that formalism and realism are at once impossible and entrenched.
P. Shlag
doaj   +1 more source

The Mitochondrial Guardian α‐Amyrin Mitigates Alzheimer's Disease Pathology via Modulation of the DLK‐SARM1‐ULK1 Axis

open access: yesAdvanced Science, EarlyView.
Dietary habits play a key role in chronic diseases, and higher annual consumption of fruit and vegetable may lower risk of dementia. Artificial intelligence predicts the lipid‐like compound α‐Amyrin (αA) from plants with edible peels as a drug candidate against Alzheimer's disease.
Shu‐Qin Cao   +36 more
wiley   +1 more source

Coupling Nitrogenous Organic Wastewater Treatment and Biorefinery via N‐Cycling Bacterium

open access: yesAdvanced Science, EarlyView.
The vast reservoir of nitrogenous organic pollutants in industrial wastewaters can serve as untapped carbon‐nitrogen resources. This study employs the newly discovered Paracoccus sp. ZQW‐1 as a versatile chassis to simultaneously achieve N‐methylpyrrolidone (NMP) wastewater depuration and polyhydroxybutyrate (PHB) synthesis.
Ziqian Wang   +3 more
wiley   +1 more source

Legal Realism and Health Criminal Law Reform in the Era of Medical and Technological Advances

open access: yesAdliya
Health criminal law faces evolving challenges driven by rapid technological advancements and shifting social dynamics. Issues such as medical malpractice, drug counterfeiting, patient data privacy, and equitable access to healthcare require legal ...
Martina Nilamsari   +2 more
doaj   +1 more source

Classifying and Analyzing Analogies

open access: yesInformal Logic, 2001
Analogies come in several forms that serve distinct functions. Inductive analogy is a common type of analogical argument, but critical thinking texts sometimes treat all analogies as inductive.
Bruce N. Waller
doaj   +1 more source

Ultrasound‐Boosted Liposomal Prodrug Overcomes Age‐Associated Biodistribution Disparity in Pediatric Solid Tumor Therapy

open access: yesAdvanced Science, EarlyView.
The age‐associated disparity of nanocarrier biodistribution limits the nanotherapeutics of childhood solid tumors. This study developed an ultrasound‐activated liposomal prodrug (CSCPTL) to overcome the age‐associated disparity of off‐target distribution.
Danfei Chen   +8 more
wiley   +1 more source

Russian Legal Realism: A New Paradigm for Understanding Law and a Means of Overcoming the Legal Crisis? Book Review: E. N. Tonkov, Russian Legal Realism

open access: yesТеоретическая и прикладная юриспруденция
This article is devoted to E. N. Tonkov’s monograph, “Russian Legal Realism” (series: Interpretation of the Sources of Law), the first comprehensive study in Russian of the methodology, foundations, and evolution of Russian legal realism.
N. S. Nizhnik
doaj  

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