Results 91 to 100 of about 3,059,732 (298)

Warner's Safe Remedies ...

open access: yes, 2017
Trade card/ink blotter advertising Warner's Safe Remedies, a line of proprietary remedies prepared by the Warner Safe Remedies Co., Rochester, N ...

core  

UDP‐Glucose‐6‐Dehydrogenase Mediated O‐GlcNAcylation of Tight Junction Protein 1 Suppresses Metastasis in Renal Cell Carcinoma

open access: yesAdvanced Science, EarlyView.
Our research unveiled a regulatory paradigm wherein TRIM25 orchestrates the ubiquitin‐mediated degradation of UGDH. UGDH modulates the protein stability of TJP1 by regulating O‐GlcNAcylation levels, effectively impeding the metastasis of ccRCC. Our insights elevate UGDH to a pivotal biomarker and tumor suppressor, marking the first demonstration that ...
Xiaolin Chen   +13 more
wiley   +1 more source

(LEGAL AUDIT IN THE PENALTY JUDICIARY AND ITS SOME PROBLEMS OF APPROPRIATE CONSTITUTION)

open access: yes, 2017
Bu çalışmada Türk ceza muhakemesi hukukunda kanun yolları denetimi bazı yönlerden incelenmiştir. Kanun yolları denetiminde yargısal teşkilatın ne kadar etkin olduğu ve anayasaya ne kadar uygun olduğu açıklanmaya çalışılmıştır.
Oğuzcan Kutkan   +2 more
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Legal Momentum : the Women\u27s Legal Defense and Education Fund

open access: yes, 2021
Legal Momentum, a 501(c)3 nonprofit, founded in 1970 is the oldest legal advocacy group for women in the United States, formerly known as NOW Legal Defense and Education Fund.
Legal Momentum (Organization)
core  

Gm26550 Modulates Learning and Memory by Increasing IGF1 mRNA Expression and Stability in Nrf2−/− Mice

open access: yesAdvanced Science, EarlyView.
The present study shows that Nrf2 directly binds to the Gm26550 promoter, thereby activating Gm26550 transcription and increasing its expression. Mechanistically, Gm26550 promotes IGF1 expression by functionally antagonizing miR‐26a‐5p‐mediated repression and sequestering the RBP KHSRP, thereby enhancing hippocampal neuronal synaptic plasticity and ...
Hongfang Wang   +12 more
wiley   +1 more source

Remedies and Resistance

open access: yes, 1983
Law mediates between the ideal and the real. American constitutional law, in particular, is a realm of idealization tempered by the claims of a resistant, unruly reality.
Gewirtz, Paul
core  

Organoid Brain‐Machine‐Interface Devices for Central Nervous System Repair

open access: yesAdvanced Science, EarlyView.
We envision organoid brain‐machine‐interface (Organoid‐BMI) devices as new biohybrid bidirectional communication pathways to connect the human CNS and the external world for personalized CNS repair and regeneration. ABSTRACT Central nervous system (CNS) repair and regeneration suffer from tremendous clinical challenges due to current limitations in ...
Yantao Xing   +10 more
wiley   +1 more source

The Challenges of AI in Administrative Law and the Need for Specific Legal Remedies: Analysis of Polish Regulations and Practice

open access: yesCentral European Public Administration Review
There are many new challenges to the classic approach to decision-making in administrative law. Public authorities are discovering the potential of AI systems to improve the efficiency and accuracy of administrative proceedings.
Jowanka Jakubek-Lalik
doaj   +1 more source

A Second Pathogenic Protein, PolyGN2C‐iso2, Reveals a Dual‐Protein Pathology in Neuronal Intranuclear Inclusion Disease

open access: yesAdvanced Science, EarlyView.
This study reveals that NOTCH2NLC transcript variant 2 generates PolyGN2C‐iso2, an aggregating protein present within intranuclear inclusions of NIID patient tissues. A novel mouse model expressing PolyGN2C‐iso2 recapitulates white matter abnormalities and cognitive deficits, mechanistically linked to mitochondrial dysfunction. These findings support a
Kang Zhang   +22 more
wiley   +1 more source

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