Results 141 to 150 of about 27,815,291 (283)
Advanced Science, EarlyView.The interaction between trophoblasts and decidual polymorphonuclear myeloid‐derived suppressor cells (dPMN‐MDSCs) via the XCL1–XCR1 axis is crucial for fetal development during the third trimester. Disruption of this axis impairs FOXO1 activity and causes metabolic imbalance in dPMN‐MDSCs, contributing to adverse outcomes associated with advanced ...
Meiqi Chen +12 more
wiley +1 more source
Advanced Science, EarlyView.A large‐scale multiomic dataset (proteomic and metabolomic) comprising 3,060 plasma samples were analyzed to identify proteins, metabolites, pathways, and protein‐associated drugs linked to Alzheimer’s Disease (AD) independently of apolipoprotein E (APOE). AD was associated with a distinct molecular signature that captures.
Fuhai Li +22 more
wiley +1 more source
Studying Academic Lawyers' Information-Seeking to Inform the Design of Digital Law Libraries [PDF]
, 2006 We report findings from the initial phase of our study on legal information seeking, which comprised a series of semi-structured interviews and naturalistic observations of academic law students and staff looking for electronic legal information.
Makri, S.
core +1 more source
Advanced Science, EarlyView.Advanced clear cell renal cell carcinoma metastasis is driven by a FOXC2+ tumor subpopulation. These cells execute vasculogenic mimicry for dissemination and secrete LAMA4. LAMA4 engages macrophage ITGA6, activating the STAT6/GATA3 axis to polarize macrophages into a pro‐metastatic, immunosuppressive phenotype.
Jiaxi Yao +11 more
wiley +1 more source
Symposium Introduction: The Myth of Moral Justice: Why Our Legal System Fails to Do What\u27s Right [PDF]
, 2006 I wrote The Myth ofMoral justice,\u27 primarily, as a moral critique of the legal system. In examining the rituals and practices of the law under moral criteria-its obsessive focus on zero-sum contests, its dedication to cold rules and procedural ...
Rosenbaum, Thane
core +1 more source
Advanced Science, EarlyView.The diagram depicts the endothelial‐protective mechanism of magnesium lithospermate B (MLB) in sepsis‐associated lung injury. MLB binds GPX4 at Gly79, disrupts its interaction with FUNDC1, prevents mitophagy‐mediated GPX4 degradation, restores mitophagic flux, reduces ROS, and limits ferroptosis.
Zhixi Li +10 more
wiley +1 more source
Special issue on Apologies: Introduction
Oñati Socio-Legal Series, 2017 What is the place of apology in law? What is the meaning of apology in a complex landscape of meanings based on a socio-legal appreciation of legal concepts?
Robyn Carroll, Prue Vines
doaj
Advanced Science, EarlyView.ABSTRACT Organoid research offers valuable insights into human biology and disease, but reproducibility and scalability remain significant challenges, particularly for epithelial organoids. Here, we present an integrated microfluidic platform that addresses these limitations by enabling high‐throughput generation of uniform hydrogel microparticles ...
Barbora Lavickova +8 more
wiley +1 more source
The Evolution of the Law, as a Mode for Regulating Everyday Life, from an Ecuadorian Perspective
Revista Facultad de Jurisprudencia, 2019 This document refers to Law’s evolution as a tool for regulating social life during the different historical ages—in the Mesopotamian, Greek, Early Medieval and Inca times, and Roman civilizations, and their successors in Law: of the medieval, modern and
Dominique Unda Mateus
doaj
Advanced Science, EarlyView.Multiomics integration analysis reveals the “cystic fluid–tumor cell” metabolic coupling that mediates active choline/ethanolamine uptake of tumor cells from cystic fluid and PC/PE synthesis pathways reprogramming that mediating autophagy pathway activation within ACP. ABSTRACT Adamantinomatous craniopharyngioma (ACP), a benign yet highly recurrent and
Dongting Chen +9 more
wiley +1 more source