Results 71 to 80 of about 247,591 (259)

Stiffness‐Activated Stellate Cells Drive Pancreatic Cancer Liver Colonization via GMFG‐TNS4 Signaling

Advanced Science, EarlyView.
Fibrotic liver stiffness activates hepatic stellate cells through Piezo1‐dependent calcium influx and ER stress, promoting EV‐associated GMFG release. Delivered GMFG engages TNS4 in pancreatic cancer cells, triggering FAK/AKT signaling, adhesion, and fatty acid synthesis.
Biwen Zhu, Jian Wan, Xue Zhang, Jiashuai Yan, Xi Chen, Xiaoqi Guan, Qianqian Ren, Tao Yang, Di Wu, Qingsong Guo, Yibing Guo, Yuhua Lu   +11 more
wiley   +1 more source

Countermeasures for legal issues to realize autonomous shipping

Nihon Kikai Gakkai ronbunshu, 2018
In recent years, engineering technology has become essential for our daily life. We cannot live without civil engineering or information technology even for one day.
Ayako UMEDA, Etsuro SHIMIZU, Kengo MINAMI, Toshiyuki MIYOSHI   +3 more
doaj   +1 more source

ZER1 Restrains Pressure Overload‐Induced Cardiac Remodeling by Targeting DVL2 for Gly/N‐Degron‐Dependent Degradation

Advanced Science, EarlyView.
Pressure overload suppresses cardiomyocyte ZER1, weakening CRL2Zer1‐mediated DVL2 degradation and allowing DVL2 accumulation. Elevated DVL2 activates CaMKII‐HDAC4‐MEF2C signaling, drives fetal gene reactivation, and promotes pathological remodeling.
Mingchao Jiang, Zhehao Lin, Lu Chen, Ying Ni, Jun Zhou, Wenjuan Zhang, Huilin Wang, Peifeng Ying, Xiu Lu, Kai Wang, Qingran Kong, Naxin Xu, Dingsheng Zhao, Jianwei Li, Guohui Zhong, Xingchen Meng, Sarkawt Hamad, Junmeng Zheng, Yuan Fu, Rongjiang Qin, Xuran Chu, Shangxuan Li, Youyou Li, Yili Wu, Yi Wang, Weihong Song, Yingxian Li, Shukuan Ling   +27 more
wiley   +1 more source

Legal analysis of the nature of the coordination rules in constitutions of the countries of Northern Europe

Контуры глобальных трансформаций: политика, экономика, право, 2015
The author for the first time used the coordination approach to the consideration of legal phenomena, through which we can examine the legal phenomenon from a new angle of view. The author conducts such research on the example of the constitutions of the
A. A. Maksurov
doaj  

Compliance Culture Shaping: The Way to Cultivate Compliance Awareness within the Enterprise [PDF]

SHS Web of Conferences
Shaping a compliance culture requires companies to establish an internal environment that promotes compliance with laws, regulations, and ethical norms.
Tian Zhen
doaj   +1 more source

MAM‐Localized MANF Counteracts Microinflammatory Stress to Attenuate Mitochondrial Dysfunction and Cataractogenesis in High Myopia

Advanced Science, EarlyView.
Chronic microinflammation in high myopia suppresses MANF in lens epithelial cells. MANF normally resides within MAMs and promotes ubiquitin‐mediated degradation of the ER Ca2+ pump SERCA2. MANF loss causes pathological SERCA2 accumulation, MAM hyperassembly, and disrupted ER‐to‐mitochondria Ca2+ transfer, leading to mitochondrial failure, oxidative ...
Xin Liu, Hao Li, Ching Kang, Dongling Guo, Shuyu Liu, Jiaqi Meng, Zhiqian Huang, Yu Du, Xiangjia Zhu   +8 more
wiley   +1 more source

New Frontiers in Clinical Legal Education: Harnessing Technology to Prepare Students for Practice and Facilitate Access to Justice

Australian Journal of Clinical Education, 2019
The increased use of technology in legal practice requires law schools to provide students with effective learning opportunities to prepare them for future practice.
Francina Cantatore
doaj   +1 more source

Research on the Design Concept and Practice of Corporate Compliance Governance Systems [PDF]

SHS Web of Conferences
Considering the current global economic integration and the rapid development of the market economy, corporate compliance and governance involve compliance with legal regulations and many comprehensive issues, both internal and external.
Tian Zhen
doaj   +1 more source

Eco‐Friendly Solvent System for Inkjet Deposition of Wide Bandgap Perovskite Solar Cells Enabling Tandem Integration

Advanced Science, EarlyView.
The fabrication of wide‐bandgap perovskite thin films via green solvents integrated with inkjet printing is developed. Controlled crystallization of the perovskite layer is achieved by optimizing ink formulation and additive engineering, enabling power conversion efficiencies above 17% for single junctions and 28% for perovskite/silicon tandem solar ...
Uma Kousalya Dangudubiyyam, Raphael Pesch, Ozan Karakaya, Theresa Kuechle, Faranak Sadegh, Nils W. Rosemann, Henry Weber, Ralf Niemann, Fabian Fertig, Johannes Sutter, Jinzhao Li, Gerardo Hernandez Sosa, Ulrich W. Paetzold   +12 more
wiley   +1 more source

Legal Barriers in Developing Educational Technology

Vietnam Journal of Education
The integration of technology in education has transformed teaching and learning, making digital tools essential in the context of Industry 4.0. However, the rapid evolution of educational technology poses significant legal challenges that must be ...
Cam Ai Tran, Truc Thanh Lam Nguyen
doaj   +1 more source