Results 41 to 50 of about 8,089 (260)
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
The Primacy of Civic Life: Aristotle’s Critique of Hippodamus
LawsThis article contributes to ongoing debates between political scientists and the burgeoning civic education reform movement over the nature and goals of political inquiry and the need for a careful analysis of political methodology.
Sebastian R. Graham, Matthew K. Reising
doaj +1 more source
Robotics: Science and Systems IX, 2013 Legible motion --- motion that communicates its intent to a human observer --- is crucial for enabling seamless human-robot collaboration. In this paper, we propose a functional gradient optimization technique for autonomously generating legible motion.
Anca D. Dragan, Siddhartha S. Srinivasa
openaire +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Legibility of Sans-Serif Typeface on Different Paper Grades Made from Invasive Alien Plant Species
Applied SciencesInvasive alien plant species (IAPS) may cause threats to native biodiversity in ecosystems. Researchers have been investigating all the possible ways that they can be used effectively for other purposes.
Klementina Možina +2 more
doaj +1 more source
Ambiguïtés, erreurs et conséquences : « Rendre l’œuvre lisible »
CeROArt : Conservation, Exposition, Restauration d'Objets d'Art, 2009 According to majors codes of ethic, the aim of restoration is to « facilitate the reading » or « the understanding » of the objects. The notion of legibility applied to paintings is questioned (and opposed to the notion of perception).
Michel Favre-Félix
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
De Lancelot à Renart : comment adapter sans trahir ?
Perspectives Médiévales, 2017 L’adaptation pour la jeunesse d’un roman tel que le Lancelot en prose nécessite un certain nombre d’aménagements, dus aux dimensions de l’œuvre, au foisonnement des personnages et des aventures.
Anne-Marie Cadot-Colin
doaj +1 more source
Molecular Oncology, EarlyView.The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant +7 more
wiley +1 more source