Results 51 to 60 of about 20,584 (247)

Brief Communication: Impact of Sign Character Aspect Ratio on Legibility

Interdisciplinary Journal of Signage and Wayfinding, 2019
Signs are critical elements of the visual environment for pedestrians, drivers and other users. Regardless of their purpose, signs should be easily detected and readily legible.
John D. Bullough
doaj   +1 more source

Personalized Legibility of an Indoor Environment for People with Motor Disabilities: A New Framework

ISPRS International Journal of Geo-Information, 2020
A mental map refers to the personalized representation of spatial knowledge in the human brain and is based on the perceptions, experiences, and interactions of people with their environment. For people with motor disabilities (PWMD) some perceptions and
Ali Afghantoloee, Mir Abolfazl Mostafavi, Geoffrey Edwards, Amin Gharebaghi   +3 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

The Primacy of Civic Life: Aristotle’s Critique of Hippodamus

Laws
This article contributes to ongoing debates between political scientists and the burgeoning civic education reform movement over the nature and goals of political inquiry and the need for a careful analysis of political methodology.
Sebastian R. Graham, Matthew K. Reising
doaj   +1 more source

Searching for Legibility [PDF]

, 2003
Legibility has been ineffective as a predictor of environmental preference primarily because of its correlation with another predictor, coherence. The authors tried to separate the two predictors by careful selection of field/forest settings and by using
Leverich, Olivia L., Herzog, Thomas R., Thomas R. Herzog, Olivia L. Leverich   +3 more
core  

The effects of Chinese typeface design, stroke weight, and contrast polarity on glance based legibility

, 2016
Modern interfaces increasingly rely on screens filled with digital text to display information to users. Previous research has shown that even relatively subtle differences in the design of the on-screen typeface can influence to-device glance time in a ...
Zhao, Nan, Reimer, Bryan, Gould, David, Dobres, Jonathan, Chahine, Nadine   +4 more
core   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source