Results 51 to 60 of about 3,884 (167)

Brain Transcriptome Analysis Reveals Exercise Improves Methamphetamine‐Induced Impairments in Mouse Learning and Memory Abilities

open access: yesAddiction Biology, Volume 30, Issue 8, August 2025.
Treadmill exercise improved METH‐induced learning and memory impairment in mice.Transcriptome analysis revealed that exercise modulated key pathways including PI3K‐Akt, mTOR, and Wnt signaling. NFKBIA, CXCL12, and Vav3 were identified as potential mediators of the beneficial effects.
Qiuyue Huang   +6 more
wiley   +1 more source

Legionellosis Outbreak Associated with Asphalt Paving Machine, Spain, 2009

open access: yesEmerging Infectious Diseases, 2010
From 1999 through 2005 in Alcoi, Spain, incidence of legionellosis was continually high. Over the next 4 years, incidence was lower, but an increase in July 2009 led health authorities to declare an epidemic outbreak.
Mireia Coscollá   +3 more
doaj   +1 more source

Drug Search and Design Considering Cell Specificity of Chemically Induced Gene Expression Profiles for Disease‐Associated Tissues

open access: yesMolecular Informatics, Volume 44, Issue 5-6, June 2025.
We proposed a novel computational method that can search for drug candidate compounds and generate new drug‐like structures considering cell‐specific gene expression patterns in diseased cells. The proposed method is expected to be useful for omics‐based drug discovery.
Chikashige Yamanaka   +3 more
wiley   +1 more source

Prevention and Control of Legionella Infections in Mountain Huts – the New International Recommendation of the Medical Commission of the Union Internationale des Associations d’Alpinisme (UIAA MedCom)

open access: yesHealth Promotion & Physical Activity, 2020
Legionnaire’s disease is a life threatening respiratory tract infection that is commonly associated with a stay in communal accommodations such as hotels, hostels, guesthouses and camping sites.
Enrico Donegani   +6 more
doaj   +1 more source

The Respiratory Tract Microbiome and Human Health

open access: yesMicrobial Biotechnology, Volume 18, Issue 5, May 2025.
The respiratory tract microbiome (RTM) trains the immune system and protects against infections. Changes in the RTM are linked to various respiratory diseases. High‐throughput methodologies and computational biology can improve our understanding of the RTM, paving the way for new diagnostic tools, treatments and preventive strategies to improve ...
Patricia Fernández de Córdoba‐Ansón   +4 more
wiley   +1 more source

Screening of Legionella pneumophila from water sources in the hospitals in Jakarta

open access: yesHealth Science Journal of Indonesia, 2019
Latar belakang: Pneumonia akibat bakteri Legionella masih menjadi masalah di berbagai tempat di dunia; menjadi penyebab 2-15 % dari pneumonia yang perlu di rawat di Rumah Sakit.
Lucky Moehario   +3 more
doaj   +1 more source

DeepQA: A Unified Transcriptome‐Based Aging Clock Using Deep Neural Networks

open access: yesAging Cell, Volume 24, Issue 5, May 2025.
DeepQA, a unified aging clock based on mixture of experts which is trained on both healthy and unhealthy subjects. ABSTRACT Understanding the complex biological process of aging is of great value, especially as it can help develop therapeutics to prolong healthy life.
Hongqian Qi   +6 more
wiley   +1 more source

Uncovering the Effects and Molecular Mechanisms of Shaoyao Decoction Against Colorectal Cancer Using Network Pharmacology Analysis Coupled With Experimental Validation and Gut Microbiota Analysis

open access: yesCancer Medicine, Volume 14, Issue 6, March 2025.
ABSTRACT Background Chronic gut inflammation and dysbiosis contribute significantly to colorectal cancer (CRC) development. Shaoyao decoction (SYD) is a well‐established Chinese medicine prescription. Besides ameliorating CRC via anti‐inflammatory effects, SYD modulates gut microbiota (GM) to improve inflammatory responses in ulcerative colitis (UC ...
Yaojun Rong   +8 more
wiley   +1 more source

Combination of Heat Shock and Enhanced Thermal Regime to Control the Growth of a Persistent Legionella pneumophila Strain

open access: yesPathogens, 2016
Following nosocomial cases of Legionella pneumophila, the investigation of a hot water system revealed that 81.5% of sampled taps were positive for L. pneumophila, despite the presence of protective levels of copper in the water.
Emilie Bédard   +7 more
doaj   +1 more source

Importance of extracorporeal membrane oxygenation (ECMO) in therapy for legionella pneumonia in patient with hairy-cell leucosis

open access: yesИнновационная медицина Кубани, 2019
Clinical observation of the patient with legionella pneumonia which developed in the setting of hairy-cell leukosis, required use of extracorporeal membrane oxygenation for controlling life-threatening hypoxia is presented. Active diagnostic approach for
A. A. Skopets   +2 more
doaj   +1 more source

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