Results 81 to 90 of about 8,079 (179)

Uncovering the Effects and Molecular Mechanisms of Shaoyao Decoction Against Colorectal Cancer Using Network Pharmacology Analysis Coupled With Experimental Validation and Gut Microbiota Analysis

open access: yesCancer Medicine, Volume 14, Issue 6, March 2025.
ABSTRACT Background Chronic gut inflammation and dysbiosis contribute significantly to colorectal cancer (CRC) development. Shaoyao decoction (SYD) is a well‐established Chinese medicine prescription. Besides ameliorating CRC via anti‐inflammatory effects, SYD modulates gut microbiota (GM) to improve inflammatory responses in ulcerative colitis (UC ...
Yaojun Rong   +8 more
wiley   +1 more source

Enhancement of adipose stem cell quality via Cu‐MON: Transcriptome and bioinformatics analysis of normal and diabetic stem cells

open access: yesFASEB BioAdvances, Volume 7, Issue 3, March 2025.
RNA sequencing, KEGG and GO enrichment analysis showed that Cu‐MON improved ASC cell quality by regulating immune response and promoting paracrine secretion through IL‐17 signaling pathway. Cu‐MON also improved stem cell antiviral ability through Type I interferon signaling pathway.
Ruixin Pang   +3 more
wiley   +1 more source

Registry‐Based Surveillance of Severe Acute Respiratory Infections in Norway During 2021–2024

open access: yesInfluenza and Other Respiratory Viruses, Volume 19, Issue 2, February 2025.
ABSTRACT Background In 2021, the Norwegian Institute of Public Health established temporary registry‐based surveillance of severe acute respiratory infections (SARI). We aimed to describe the surveillance system and evaluate selected attributes to inform the establishment of a permanent SARI surveillance system.
Elina Seppälä   +8 more
wiley   +1 more source

Elucidating novel immune profiles for predicting infection in high‐risk cohorts: a pilot study in patients with relapsed and refractory chronic lymphocytic leukaemia

open access: yesClinical &Translational Immunology, Volume 14, Issue 8, 2025.
In the present study, we identified several unique protein and RNA signatures that could be used to predict infection in relapse and refractory patients. We highlight the need for comprehensive immune profiling of high‐risk cancer cohorts. Abstract Objectives Chronic lymphocytic leukaemia (CLL) patients are at increased risk for infection, with the ...
Lewis J Williams   +8 more
wiley   +1 more source

Transcriptomic Insights Into Vitellogenesis‐Inhibiting Hormone Regulation of Ovarian Gene Expression in the Kuruma Prawn Marsupenaeus japonicus

open access: yesAquaculture Research, Volume 2025, Issue 1, 2025.
Vitellogenesis‐inhibiting hormone (VIH) is known to suppress vitellogenin gene expression and consequently inhibit ovarian development in many decapod species. However, the broader effects of VIH on other ovarian genes, which are crucial for understanding the molecular mechanisms by which VIH regulates vitellogenesis, have not been investigated.
Azreen Syazana Nazaruddin   +4 more
wiley   +1 more source

Pseudogene BNIP3P1 Regulates H. pylori–Induced Apoptosis in Gastric Mucosal by Acting on the miR‐411‐5p/BNIP3 Axis

open access: yesCellular Microbiology, Volume 2025, Issue 1, 2025.
Helicobacter pylori (H. pylori) is one of the major causes of gastric mucosal damage, and infection with H. pylori induces an immune response with gastric mucosal cells, which reduces gastric mucosal damage. The pseudogene BNIP3P1, sharing a remarkable 95.92% similarity with its well‐characterized counterpart BNIP3, has largely remained unexplored.
Andong Zhang   +11 more
wiley   +1 more source

Cytoadhesion of Plasmodium falciparum‐Infected Red Blood Cells Changes the Expression of Cytokine‐, Histone‐ and Antiviral Protein‐Encoding Genes in Brain Endothelial Cells

open access: yesMolecular Microbiology, Volume 122, Issue 6, Page 948-967, December 2024.
Cytoadhesion of P. falciparum‐infected red blood cells to endothelial cells leads to significant upregulation of genes associated with immune response, nucleosome assembly, NF‐kappa B signaling, and angiogenesis in these cells. Increasing the temperature to 40°C (fever) led to further upregulation of many genes, particularly those involved in cytokine ...
Johannes Allweier   +7 more
wiley   +1 more source

Genotypic diversity of Legionella pneumophila in environmental and clinical strains assessed by Sequence-Based Typing, in association with retrospective clinical surveillance in Northern Italy

open access: yesAnnals of Agricultural and Environmental Medicine, 2016
Objective The study aimed to evidence previous cases of legionellosis or proven or suspected pneumonia in seven hospital facilities for the mentally disabled in Northern Italy, where no clinical surveillance had been previously carried out. An additional
Annalisa Bianchi   +3 more
doaj   +1 more source

Characterization of Francisella species isolated from the cooling water of an air conditioning system. [PDF]

open access: yes, 2015
Strains of Francisella spp. were isolated from cooling water from an air conditioning system in Guangzhou, China. These strains are Gram negative, coccobacilli, non-motile, oxidase negative, catalase negative, esterase and lipid esterase positive.
Atwill, Edward   +6 more
core   +3 more sources

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