Results 51 to 60 of about 7,913 (200)

JAK Inhibitors for Treatment of VEXAS Syndrome: A Systematic Review of 186 Cases

Dermatology Research and Practice, Volume 2025, Issue 1, 2025.
Objectives: Vacuoles, E1 enzyme, X‐linked, autoinflammatory, somatic (VEXAS) syndrome is an autoinflammatory disease with a wide spectrum of manifestations and no standard treatment. Janus kinase inhibitors (JAK‐I) are small‐molecule drugs that affect many molecular pathways.
Saeed Bahramian, Patrick Fazeli, Arezou Rafati, Sardar Demokri, Huria Memari, Amirali Soheili, Farzad Esmaeili, Mohammad Pourmehdi Ardebili, Haniye Erfani, Seyed Mohammad Vahabi, Ioannis D. Bassukas   +10 more
wiley   +1 more source

Legionnaires’ Disease

, 2007
The incidence of legionnaires’ disease (LD) seems to increase with age, particularly in males [36]. It was considered an infrequent cause of pneumonia in the past, but it currently ranks second to pneumococcus in the list of etiologic agents of severe community-acquired pneumonia (CAP) of bacterial origin [2, 24, 60, 89]. Considering less severe cases,
Roig, J., Sabria, M., Castella, X.
openaire   +1 more source

Unraveling the Genetic Predisposition on Respiratory Infections: From Single Nucleotide Polymorphisms to Inborn Errors of Immunity

Interdisciplinary Perspectives on Infectious Diseases, Volume 2025, Issue 1, 2025.
Background: The complex interplay between the human genome and microbial pathogens has captured scientific interest, leading to profound insights into the genetic basis of host’s susceptibility to infections. Objective: Here, we explore the spectrum of genetic susceptibility in infectious diseases, ranging from common single nucleotide polymorphisms ...
Francesca Conti, Mattia Moratti, Bianca Laura Cinicola, Riccardo Castagnoli, Riccardo Papa, Silvia Federici, Giuliana Giardino, Lucia Leonardi, Maria Sangerardi, Annarosa Soresina, Gian Luigi Marseglia, Michele Miraglia Del Giudice, Marcello Lanari, Caterina Cancrini, Vassilios Lougaris, Fabio Cardinale, on behalf of the Immunology Committee of the Italian Society of Pediatric Allergology and Immunology (SIAIP), Suraiya Saleem   +17 more
wiley   +1 more source

Syndromic surveillance for local outbreaks of lower-respiratory infections: would it work? [PDF]

PLoS ONE, 2010
BackgroundAlthough syndromic surveillance is increasingly used to detect unusual illness, there is a debate whether it is useful for detecting local outbreaks.
Cees C van den Wijngaard, Liselotte van Asten, Wilfrid van Pelt, Gerda Doornbos, Nico J D Nagelkerke, Gé A Donker, Wim van der Hoek, Marion P G Koopmans   +7 more
doaj   +1 more source

Microbial Dynamics and Quality Monitoring in Biopharmaceutical Production

ChemBioEng Reviews, Volume 11, Issue 6, December 2024.
This review evaluates current methods for bioprocessing of non‐mammalian cells for biopharmaceuticals synthesis. Advanced technology and standardized testing are needed to improve production, reduce costs, prevent contamination, and enhance supply availability.
Rosha Pashang, Kimberley A. Gilbride, Jannis Wenk   +2 more
wiley   +1 more source

Legionnaires’ Disease: Clinicoradiological Comparison of Sporadic Versus Outbreak Cases

Clinical Medicine Insights: Circulatory, Respiratory and Pulmonary Medicine, 2017
Background: In 2015, New York City experienced the worst outbreak of Legionnaires’ disease in the history of the city. We compare patients seen during the 2015 outbreak with sporadic cases of Legionella during the past 5 years.
Hafiz Rizwan Talib Hashmi, Lakshmi Saladi, Frances Petersen, Misbahuddin Khaja, Gilda Diaz-Fuentes   +4 more
doaj   +1 more source

Sex differences in CD8+ T cell responses during adaptive immunity

WIREs Mechanisms of Disease, Volume 16, Issue 5, September/October 2024.
Figure 1. Current trends of sex differences shaping CD8+ T cell‐mediated immunity. Sex bias affecting T cell immunity have been characterized both at the cellular (genetic and epigenetic modifications) and tissue level (gonadal structures and their sex hormones).
Paul Jerard Layug, Harman Vats, Kamali Kannan, Janilyn Arsenio   +3 more
wiley   +1 more source

Nosocomial Legionnaires’ Disease: Clinical and Radiographic Patterns

Canadian Journal of Infectious Diseases, 1992
From 1981 to 1991, 55 patients (33 males, 22 females, mean age 58.6 years) with nosocomial Legionnaires’ disease were studied. The mortality rate was 64%. One-half of the patients developed nosocomial Legionnaires’ disease within three weeks of admission.
Thomas J Marrie, David Haldane, Gregory Bezanson   +2 more
doaj   +1 more source

Probe‐capture targeted next‐generation sequencing: A novel approach for pathogen and antimicrobial resistance detection in sepsis

Clinical and Translational Discovery, Volume 5, Issue 4, August 2025.
Chitra Ravi, Adam D. Irwin, Patrick N. A. Harris   +2 more
wiley   +1 more source

NPCC4: Climate change and New York City's health risk

Annals of the New York Academy of Sciences, Volume 1539, Issue 1, Page 185-240, September 2024.
Abstract This chapter of the New York City Panel on Climate Change 4 (NPCC4) report considers climate health risks, vulnerabilities, and resilience strategies in New York City's unique urban context. It updates evidence since the last health assessment in 2015 as part of NPCC2 and addresses climate health risks and vulnerabilities that have emerged as ...
Thomas Matte, Kathryn Lane, Jenna F. Tipaldo, Janice Barnes, Kim Knowlton, Emily Torem, Gowri Anand, Liv Yoon, Peter Marcotullio, Deborah Balk, Juanita Constible, Hayley Elszasz, Kazuhiko Ito, Sonal Jessel, Vijay Limaye, Robbie Parks, Mallory Rutigliano, Cecilia Sorenson, Ariel Yuan   +18 more
wiley   +1 more source