Results 101 to 110 of about 3,754 (303)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

The finale of the Polish Legions' heroic struggle (1916-1918) [PDF]

, 2008
Zdigitalizowano i udostępniono w ramach projektu pn. Rozbudowa otwartych zasobów naukowych Repozytorium Uniwersytetu w Białymstoku, dofinansowanego z programu „Społeczna odpowiedzialność nauki" Ministra Edukacji i Nauki na podstawie umowy SONB/SP/512497 ...
Snopko, Jan
core  

Lapsepõlvest laskurseltsides, nooruseast Poola leegionides, täiseast Poola armees. Taastatud Poola armee ajalugu 1914–1920 [From Childhood of the Riflemen’s Association Through Middle Age of the Polish Legions to Adulthood in the Polish Army. History of Rebuilt Polish Army 1914–1920] [PDF]

, 2018
The purpose of this article is to present the historical process of forming the independent Polish Armed Forces during the Great War. I will also analyse the myth of the Polish Legions – the national myth of the Second Polish Republic.
Przybylak, Michał
core   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Russian Civil War and the role of the Czechoslovak Legions [PDF]

, 2012
Bakalářská práce Ruská občanská válka a úloha československých legií je zaměřena na analýzu vzniku a průběhu občanské války v Rusku. Konkrétně se zabývá průběhu první světové války na ruském území, revolucí roku 1917, spojenecké pomoci bělogvardějcům ...
Šleis, Jan
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Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Media reflections on czechoslovak legions 1918-1939 [PDF]

, 2018
Thesis Media reflections on Czechoslovak Legions 1918-1939 analyzes period articles, theater plays and publications dedicated to the participants of the first resistance and describes how the Czechoslovak public was informed about legionaries based on ...
Látalová, Kristýna
core   +1 more source

Literární výchova badatelsky – M. R. Štefánik v uměleckém zpracování

Český Jazyk a Literatura
This article presents the method of inquiry-based teaching and its possibilities in teaching Czech language and literature. The authors proposed a lesson structure for the 9th grade of elementary school, which is dedicated to the personality of Milan ...
Jindřiška Svobodová, Štěpán Svoboda   +1 more
doaj   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source