Results 21 to 30 of about 111,424 (313)

The role of globalization in drug development and access to orphan drugs: orphan drug legislation in the US/EU and in Latin America [v1; ref status: indexed, http://f1000r.es/3ix]

F1000Research, 2015
Compared to a decade ago, nearly three times as many drugs for rare diseases are slated for development. This article addresses the market access issues associated with orphan drug status in Europe and the United States in contrast to the legislation in ...
Renée J.G. Arnold, Lida Bighash, Alejandro Bryón Nieto, Gabriela Tannus Branco de Araújo, Juan Gabriel Gay-Molina, Federico Augustovski   +5 more
doaj   +1 more source

Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni, Cecile Pagan, Antony Citterio‐Quentin, Isabelle Rouvet, Giulia Dingeo, Cyril Hanin, Claudine Laurent‐Levinson, Samia Pichard, Bénédicte Héron, Clément Gourguechon, Daniele Mandia, Jerome Guitton, Carole Lacout, Nicolas Schleinitz, Florient Potier, Olivier Flabeau, Elsa Besse‐Pinot, Foudil Lamari, Magali Pettazzoni, Yann Nadjar   +19 more
wiley   +1 more source

A Deep Dive into the Botanical and Medicinal Heritage of Taxus

Plants
The genus Taxus comprises a unique group of gymnosperms known for their botanical longevity, cultural significance, and exceptional pharmacological potential.
Alex-Robert Jîjie, Dan Iliescu, Laura Sbârcea, Casiana Boru, Dalia Pătrașcu, Oana Andrada Iftode, Ionela-Daliana Minda, Ștefana Avram, Cristina-Maria Trandafirescu, Cristina Adriana Dehelean, Elena-Alina Moacă   +10 more
doaj   +1 more source

Access to Orphan Drugs: A Comprehensive Review of Legislations, Regulations and Policies in 35 Countries. [PDF]

PLoS ONE, 2015
OBJECTIVE:To review existing regulations and policies utilised by countries to enable patient access to orphan drugs. METHODS:A review of the literature (1998 to 2014) was performed to identify relevant, peer-reviewed articles. Using content analysis, we
Todd Gammie, Christine Y Lu, Zaheer Ud-Din Babar   +2 more
doaj   +1 more source

Exploring the Legitimisation of Cannabis: A Narrative Review of Historical Uses, Legislative Changes and Medical Implication [PDF]

Journal of Clinical and Diagnostic Research
The exploration of cannabis, particularly its legitimisation and multifaceted uses, is pivotal in understanding its historical significance, chemical composition, therapeutic potential, and societal implications. This narrative review traverses millennia
Priyanshu Raj, Bhagyesh Sapkale, Sangita Jogdand   +2 more
doaj   +1 more source

Aqueous Two‐Phase Bioinks for Discrete Packing and Compartmentalization of 3D Bioprinted Cells

Advanced Healthcare Materials, EarlyView.
Aqueous two‐phase systems (ATPS) enable the formation of biomimetic interfaces crucial for tissue engineering. However, clinical translation remains limited by the challenge of precisely controlling cellular compartmentalization. Here, we developed ATPS biomaterial inks for 3D bioprinting allowing tuneable droplet formation via NaCl modulation.
Martina Marcotulli, Arianna Iacomino, Federico Serpe, Lucia Iafrate, Marco Bastioli, Giorgia Montalbano, Michele D'Orazio, Biagio Palmisano, Silvia Franco, Arianna Mencattini, Roberta Angelini, Eugenio Martinelli, Alessandro Corsi, Mara Riminucci, Giancarlo Ruocco, Chiara Scognamiglio, Andrea Barbetta, Gianluca Cidonio   +17 more
wiley   +1 more source

Biological Effects of Rosaceae Species in Skin Disorders—An Up-To-Date Overview

Plants
The Rosaceae family, comprising over 3000 species, has been extensively investigated for its therapeutic potential, particularly in dermatological applications.
Andreea Maria Cristea, Andreea Smeu, Ioan-Alexandru Cîmpeanu, Andrada Iftode, Sergio Liga, Diana-Simona Tchiakpe-Antal, Daliborca Vlad, Cristina Adriana Dehelean, Dan Iliescu   +8 more
doaj   +1 more source

Perspective and current state of international standards influence on prevention and treatment of diseases through the prism of developing high-quality and safe medicines

Zaporožskij Medicinskij Žurnal, 2022
The aim of the work was to examine international legislation covering the legal responsibility in the pharmaceutical field; to analyze activities of international organizations in the area of combating counterfeit drug distribution.
O. H. Aleksieiev
doaj   +1 more source

Flexible Implantable Silicon Carbide Multi‐Electrode Array (MEA) for Cell Multichannel Recording and Cell Ablation

Advanced Materials Technologies, EarlyView.
Flexible silicon carbide (SiC) microelectrode arrays enable high‐fidelity, multichannel cell extracellular recording and precise localized ablation. SiC has been extensively evaluated to persist long‐term in chronic physiological conditions while remaining robust, with excellent electrical and electrochemical stability.
Minh Anh Huynh, Matthew Barton, Sharda Yadav, Tuan‐Khoa Nguyen, Nam‐Trung Nguyen   +4 more
wiley   +1 more source

In Vitro and In Ovo Evaluation of Water-Soluble Extract from Coffea arabica Green Seeds—A Phytotherapeutic Perspective in Cutaneous Oncology

Proceedings
Introduction: Green coffee (Coffea arabica L [...]
Grațiana Ruse, Elena-Alina Moacă, Alexandra Semenescu, Ştefana Avram, Andreea Munteanu, Alex-Robert Jîjie, Diana-Simona Tchiakpe-Antal   +6 more
doaj   +1 more source