Results 21 to 30 of about 44,668 (242)

The newfound relationship between extrachromosomal DNAs and excised signal circles

open access: yesFEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Protego ergo obligo… Nuove forme di obbedienza per rinnovate forme di legittimità?

open access: yesAltre Modernità, 2019
This essay aims to analyse the relationship between work and legitimacy. This relationship is due to an increasing and pervasive expansion of the economic crisis that has significantly changed the relationship between state and citizen.
Luca Gasbarro
doaj   +1 more source

Im "Labyrinth der Legitimitäten" und Ethosanalyse. Carl Schmitt und Herfried Münkler über die neuen Kriege und Krieger

open access: yesLabyrinth: An International Journal for Philosophy, Value Theory and Sociocultural Hermeneutics, 2021
In the "Labyrinth of Legitimacy" and Ethos Analysis. Carl Schmitt and Herfried Münkler on the New Wars and New Warriors  The article analyzes Münkler's continuation of Carl Schmitt's late work on international law in the book Kriegssplitter and ...
Reinhard Mehring
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Legitimacy Theory in Management Accounting Research [PDF]

open access: yesProblemy Zarządzania, 2018
Legitimacy theory helps to understand the organization’s behavior in implementing, developing and communicating its social responsibility policies. The main assumption of legitimacy theory is fulfilling the organization’s social contract, which enables ...
Beata Zyznarska-Dworczak, PhD
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

open access: yesMolecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix   +13 more
wiley   +1 more source

The relationship between political legitimacy and economic legitimacy: empirical explorations of a novel research approach on legitimacy

open access: yesFrontiers in Political Science
The paper outlines key points of a novel research approach to empirically investigate the question of legitimacy in modern societies. This new research approach utilizes a functionalist perspective to expand the concept of legitimacy.
Zsófia S. Ignácz
doaj   +1 more source

Solidarity Economy, Social Enterprise, and Innovation Discourses: Understanding Hybrid Forms in Postcolonial Colombia

open access: yesSocial Sciences, 2019
Dominant conceptions of solidarity economy, social enterprise, and innovation (SSEI) remain poorly positioned for understanding the diverse models emerging across the global South.
Sara Calvo Martínez   +3 more
doaj   +1 more source

The State’s Attitude to Cryptocurrency as an Indicator of Its Trust in Society

open access: yesУправленческое консультирование, 2021
It is proposed to justify the applicability of indicators of state confidence in civil society, that is, the state’s faith in the loyalty of society to it and in the ability to maintain its own legitimacy.
O. A. Antoncheva, T. E. Apanasenko
doaj   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

open access: yesFEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani   +6 more
wiley   +1 more source

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