Results 41 to 50 of about 53,261 (257)
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Introduction Hyperlipidemia is a major risk factor for atherosclerotic cardiovascular disease (ASCVD). Although statins are the cornerstone of lipid‐lowering therapy, their use may be limited in some patients by adverse effects. This study evaluated the possible impact of non‐drug treatment using double‐filtration plasmapheresis (DFPP) on CD14+
Yun Cheng +3 more
wiley +1 more source
Thresholds are everywhere: A systems approach to public policy
BAR: Brazilian Administration Review, 2019 The analysis of public policies often fails to account for effects beyond mere cost-benefit analysis. Incorporating elements from the literature on system dynamics, complexity and legitimacy, the present paper develops a framework to understand long-term
Hamilton Coimbra Carvalho +2 more
doaj +1 more source
Comparative Political Studies, 2015 Although elections have become the norm not only in democratic regimes but also in autocratic ones, the legitimacy of the electoral process in different countries is often contested. Facing strong international pressures to prove democratic credentials, eventual winners have a strong incentive to ensure high levels of voter turnout. Conversely, leaders
Gonzalez-Ocantos, E +2 more
openaire +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Annual Review of Law and Social ScienceWhat makes a law or regulation legitimate? This article develops a sociological approach that locates legitimacy not outside the law but in the work performed by a network of actors that cuts across the boundaries of the state. Drawing on Weber, Habermas, and Szelenyi, we suggest that legitimacy should be understood as the element that increases the ...
Eyal, Gil, Fu, Zheng
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Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Frontiers in Political ScienceThe paper outlines key points of a novel research approach to empirically investigate the question of legitimacy in modern societies. This new research approach utilizes a functionalist perspective to expand the concept of legitimacy.
Zsófia S. Ignácz
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Do all staff members need to share the same purpose?
Annals of Business Administrative Science, 2018 It is said that when an organization embarks on a new activity, the entire organization needs to be on board with the organizational purpose of that activity.
Masami Abe
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FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source