Results 51 to 60 of about 181,630 (309)

Thresholds are everywhere: A systems approach to public policy

BAR: Brazilian Administration Review, 2019
The analysis of public policies often fails to account for effects beyond mere cost-benefit analysis. Incorporating elements from the literature on system dynamics, complexity and legitimacy, the present paper develops a framework to understand long-term
Hamilton Coimbra Carvalho, Giuliana Isabella, José Afonso Mazzon   +2 more
doaj   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Necessary Conditions for the Existence of Organizational Legitimacy

Journal of Economy Culture and Society
Organizational legitimacy is a crucial factor for ensuring survival, securing resources, facilitating growth, and stabilizing the work environment. To achieve this, an organization must determine whether it currently possesses legitimacy or needs to take
Ana Cruz Suárez, Camilo Prado Roman, Francisco Diez Martin, Emilio Diez-de Castro   +3 more
doaj   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Do all staff members need to share the same purpose?

Annals of Business Administrative Science, 2018
It is said that when an organization embarks on a new activity, the entire organization needs to be on board with the organizational purpose of that activity.
Masami Abe
doaj   +1 more source

The Work of Legitimacy

Annual Review of Law and Social Science
What makes a law or regulation legitimate? This article develops a sociological approach that locates legitimacy not outside the law but in the work performed by a network of actors that cuts across the boundaries of the state. Drawing on Weber, Habermas, and Szelenyi, we suggest that legitimacy should be understood as the element that increases the ...
Eyal, Gil, Fu, Zheng
openaire   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Reciprocity and the State: A Liberal Theory of Legitimacy [PDF]

, 2012
Under which circumstances is the state morally allowed to enact and uphold laws by the use of force against its citizens? This is the problem of legitimacy. In this thesis I develop and defend a theory of legitimacy based on reciprocity.
Ekstrand, David
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