Results 51 to 60 of about 273,562 (286)

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

open access: yesMolecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Legitimacy, Adaptation, and Resilience in Ecosystem Management

open access: yesEcology and Society, 2013
Ecologists have made great strides in developing criteria for describing the resilience of an ecological system. In addition, expansion of that effort to social-ecological systems has begun the process of identifying changes to the social system ...
Barbara A. Cosens
doaj   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

open access: yesFEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong   +3 more
wiley   +1 more source

Judicial Deliberations: uma resenha crítica

open access: yesTeoria Jurídica Contemporânea, 2016
Resumo: Mitchel Lasser, em sua aclamada obra Judicial Deliberations: a comparative analysis of judicial transparency and legitimacy (2009), oferece uma análise comparativa de três tribunais: a Corte de Cassação francesa, a Suprema Corte americana e a ...
Guilherme da Franca Couto Fernandes de Almeida
doaj   +1 more source

Conclusion: The legitimacy of International Law

open access: yes, 2020
In memory of Thomas Franck International lawyers have been less interested in the concept of legitimacy than political scientists or international-relations scholars.
Charlesworth, Hilary
core   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

open access: yesFEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai   +8 more
wiley   +1 more source

Contested Legitimacy

open access: yesPerspective Politice, 2019
There is a growing demand to change the institutions and constitutional design as response to the impact of the electorate or other recently emerging movements supported mostly from various street protest actions or citizens rallies.
Jana RESCHOVÁ
doaj  

Legitimacy of inequality and the stability of income distributions in Poland [PDF]

open access: yes, 2010
The objective of this paper is to apply hypotheses derived from theories of legitimacy and distributive justice to patterns of stability in income distribution in Poland. The hypotheses specify conditions under which income differences become legitimated.
Karpiński, Z.
core  

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

open access: yesFEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell   +8 more
wiley   +1 more source

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