Results 101 to 110 of about 69,734 (293)

SMAD4 Palmitoylation Drives a Metabolic‐Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer

Advanced Science, EarlyView.
This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang, Shan Zhang, Junping Bai, Xiaobing Li, Yi Han, Min Ji, Chongyi Jiang, Xiaobei Ge, Tianyu Yu, Yongying Hou, Jun Zhang, Wangting Li, Yiran Song, Jiaying Cai, Yingqun Zhou, Liwei An, Feng Wang   +16 more
wiley   +1 more source

Public interest and legitimate expectations in the financing of political parties: general and specific aspects

, 2015
Viešojo intereso ir teisėtų lūkesčių identifikavimo bei balansavimo tematika gali būti analizuojama ir nuolat aktualizuojama įvairiose teisėkūros srityse, tarp jų – politinių partijų finansavimo reglamentavime.
Šileikis, Egidijus
core  

A Theory of Legitimate Expectations for Public Administration

, 2017
It is an unfortunate but unavoidable feature of even well-ordered democratic societies that governmental administrative agencies often create legitimate expectations (procedural or substantive) on the part of non-governmental agents (individual citizens,
Brown, Alexander,, Alexander Brown, Brown, Alexander   +2 more
core   +1 more source

GENESIS OF THE CONCEPT «LEGITIMATE INTERESTS OF THE TAXPAYER»

Juridical Journal of Samara University, 2018
The subject of the study is the origin of the term legitimate interests of the taxpayer in the domestic legislation on taxes and fees. Despite its importance for the theory and practice of tax law, this concept is not disclosed normatively, the law enforcement officer is not explained what sets the corresponding task for science. The author on the basis
openaire   +2 more sources

Full‐Body AI Agent: A Perspective on Multi‐Scale Collaborative AI for Systemic Biology and Precision Medicine

Advanced Science, EarlyView.
We propose the Full‐Body AI Agent, a multi‐scale collaborative framework with 7 biological‐layer agents. It unifies multi‐omics/clinical data via standardized protocols, enabling phenotype‐guided closed‐loop reasoning, quantitative evaluation, and LLM safeguards, with promising applications in tumor metastasis modeling and precision drug development ...
Aoqi Wang, Jiajia Liu, Jianguo Wen, Yangyang Luo, Zhiwei Fan, Liren Yang, Xi Hu, Ruihan Luo, Yankai Yu, Sophia Li, Weiling Zhao, Xiaobo Zhou   +11 more
wiley   +1 more source

Priority of public interest over legitimate expectations in constitutional jurisprudence

, 2015
Ši publikacija yra tyrimo dalis, Lietuvos teisės institutui įgyvendinant Lietuvos mokslo tarybos finansuojamą projektą „Viešojo intereso atpažinimo problema Lietuvos teisėje: kriterijai ir prioritetai“.
Beliūnienė, Lina
core  

β‐Elemene Rescues Radiation‐Induced Enteritis by Orchestrating a Host‐Microbiome Circuit That Fuels Epigenetic DNA Repair

Advanced Science, EarlyView.
This study elucidates that β‐elemene promotes cellular uptake of L. gasseri‐derived lactate by enhancing the membrane translocation of MCT1 in a CD147‐dependent manner. Intracellular lactate, through the lactylation of RBBP4 at the K26 site, recruits EP300 to the promoter regions of downstream genes (POLD1/POLD3), catalyzing H3K27ac modification.
Jiancheng He, Jiapeng Bao, Shukang Deng, Weijie Zang, Haoming Yan, Zihao Zhao, Guangze Zhang, Ruiqing Liu, Junjie Chen, Yilin Hu, Wanjiang Xue   +10 more
wiley   +1 more source

« Le sang se mit à couler » : prendre les armes pour défendre la nature

Catalonia
Continuing his work in «écopoétique», which had already led him to take interest in the representation of violence in extreme contemporary literature (cf. Littérature et écologie.
Pierre Schoentjes
doaj   +1 more source

An Integrated NLP‐ML Framework for Property Prediction and Design of Steels

Advanced Science, EarlyView.
This study presents a data‐driven framework that uses language‐processing techniques to interpret steel processing descriptions and machine‐learning models to predict mechanical properties. By organising complex process histories into meaningful groups and enabling rapid property forecasts, the work supports faster, more informed steel design through ...
Kiran Devraju, Adithya Umanath Rai, Jose Thomson, Marzie Ghorbani, Shujing Zhao, Nick Birbilis   +5 more
wiley   +1 more source

Study of Free‐Space Optical Quantum Network: Review and Prospectives

Advanced Science, EarlyView.
Free from the constraints of fiber connections, free‐space quantum network enables longer and more flexible quantum network connections. This review summarizes and comparatively analyzes free‐space quantum network experiments based on ground stations, satellites, and mobile platforms.
Hua‐Ying Liu, Zhenda Xie, Shining Zhu
wiley   +1 more source