Results 41 to 50 of about 59,164,126 (252)
Introducing Borsantrazole: A Trifunctional Boron‐Based Pyrazole That Extends the Lifespan of Amyotrophic Lateral Sclerosis Mice
Advanced Science, EarlyView.Herein we report a boron‐based pyrazole, (Borsantrazole ‐ a small molecule that selectively targets oxidative stress) that significantly increases survival, reduces weight loss, delays disease onset, and affects global protein changes in the SOD1‐G37R mouse model of ALS.Nitesh Sanghai, Rhonda Kelley, Ying Lao, M. Immanuel Reyes Madlangsakay, Prasanta Paul, M. Alejandra Llanes‐Cuesta, Jun‐Feng Wang, René P. Zahedi, Jiming Kong, Geoffrey K. Tranmer +9 morewiley +1 more sourceThe Variability of the Black Hole Image in M87 at the Dynamical Timescale
The Astrophysical Journal, 2022 The black hole images obtained with the Event Horizon Telescope (EHT) are expected to be variable at the dynamical timescale near their horizons. For the black hole at the center of the M87 galaxy, this timescale (5–61 days) is comparable to the 6 day ...Kaushik Satapathy, Dimitrios Psaltis, Feryal Özel, Lia Medeiros, Sean T. Dougall, Chi-Kwan Chan, Maciek Wielgus, Ben S. Prather, George N. Wong, Charles F. Gammie, Kazunori Akiyama, Antxon Alberdi, Walter Alef, Juan Carlos Algaba, Richard Anantua, Keiichi Asada, Rebecca Azulay, Anne-Kathrin Baczko, David Ball, Mislav Baloković, John Barrett, Bradford A. Benson, Dan Bintley, Lindy Blackburn, Raymond Blundell, Wilfred Boland, Katherine L. Bouman, Geoffrey C. Bower, Hope Boyce, Michael Bremer, Christiaan D. Brinkerink, Roger Brissenden, Silke Britzen, Avery E. Broderick, Dominique Broguiere, Thomas Bronzwaer, Sandra Bustamente, Do-Young Byun, John E. Carlstrom, Andrew Chael, Koushik Chatterjee, Shami Chatterjee, Ming-Tang Chen, Yongjun Chen, Ilje Cho, Pierre Christian, John E. Conway, James M. Cordes, Thomas M. Crawford, Geoffrey B. Crew, Alejandro Cruz-Osorio, Yuzhu Cui, Jordy Davelaar, Mariafelicia De Laurentis, Roger Deane, Jessica Dempsey, Gregory Desvignes, Jason Dexter, Sheperd S. Doeleman, Ralph P. Eatough, Heino Falcke, Joseph Farah, Vincent L. Fish, Ed Fomalont, H. Alyson Ford, Raquel Fraga-Encinas, Per Friberg, Christian M. Fromm, Antonio Fuentes, Peter Galison, Roberto García, Olivier Gentaz, Boris Georgiev, Ciriaco Goddi, Roman Gold, Arturo I. Gómez-Ruiz, José L. Gómez, Minfeng Gu, Mark Gurwell, Kazuhiro Hada, Daryl Haggard, Michael H. Hecht, Ronald Hesper, Luis C. Ho, Paul Ho, Mareki Honma, Chih-Wei L. Huang, Lei Huang, David H. Hughes, Shiro Ikeda, Makoto Inoue, Sara Issaoun, David J. James, Buell T. Jannuzi, Michael Janssen, Britton Jeter, Wu Jiang, Alejandra Jimenez-Rosales, Michael D. Johnson, Svetlana Jorstad, Taehyun Jung, Mansour Karami, Ramesh Karuppusamy, Tomohisa Kawashima, Garrett K. Keating, Mark Kettenis, Dong-Jin Kim, Jae-Young Kim, Jongsoo Kim, Junhan Kim, Motoki Kino, Jun Yi Koay, Yutaro Kofuji, Patrick M. Koch, Shoko Koyama, Carsten Kramer, Michael Kramer, Thomas P. Krichbaum, Cheng-Yu Kuo, Tod R. Lauer, Sang-Sung Lee, Aviad Levis, Yan-Rong Li, Zhiyuan Li, Michael Lindqvist, Rocco Lico, Greg Lindahl, Jun Liu, Kuo Liu, Elisabetta Liuzzo, Wen-Ping Lo, Andrei P. Lobanov, Laurent Loinard, Colin Lonsdale, Ru-Sen Lu, Nicholas R. MacDonald, Jirong Mao, Nicola Marchili, Sera Markoff, Daniel P. Marrone, Alan P. Marscher, Iván Martí-Vidal, Satoki Matsushita, Lynn D. Matthews, Karl M. Menten, Izumi Mizuno, Yosuke Mizuno, James M. Moran, Kotaro Moriyama, Monika Moscibrodzka, Cornelia Müller, Alejandro Mus Mejías, Gibwa Musoke, Hiroshi Nagai, Neil M. Nagar, Masanori Nakamura, Ramesh Narayan, Gopal Narayanan, Iniyan Natarajan, Antonios Nathanail, Joey Neilsen, Roberto Neri, Chunchong Ni, Aristeidis Noutsos, Michael A. Nowak, Hiroki Okino, Héctor Olivares, Gisela N. Ortiz-León, Tomoaki Oyama, Daniel C. M. Palumbo, Jongho Park, Nimesh Patel, Ue-Li Pen, Dominic W. Pesce, Vincent Piétu, Richard Plambeck, Aleksandar PopStefanija, Oliver Porth, Felix M. Pötzl, Jorge A. Preciado-López, Hung-Yi Pu, Venkatessh Ramakrishnan, Ramprasad Rao, Mark G. Rawlings, Alexander W. Raymond, Luciano Rezzolla, Bart Ripperda, Freek Roelofs, Alan Rogers, Eduardo Ros, Mel Rose, Arash Roshanineshat, Helge Rottmann, Alan L. Roy, Chet Ruszczyk, Kazi L. J. Rygl, Salvador Sánchez, David Sánchez-Arguelles, Mahito Sasada, Tuomas Savolainen, F. Peter Schloerb, Karl-Friedrich Schuster, Lijing Shao, Zhiqiang Shen, Des Small, Bong Won Sohn, Jason SooHoo, He Sun, Fumie Tazaki, Alexandra J. Tetarenko, Paul Tiede, Remo P. J. Tilanus, Michael Titus, Kenji Toma, Pablo Torne, Efthalia Traianou, Tyler Trent, Sascha Trippe, Ilse van Bemmel, Huib Jan van Langevelde, Daniel R. van Rossum, Jan Wagner, Derek Ward-Thompson, John Wardle, Jonathan Weintroub, Norbert Wex, Robert Wharton, Kaj Wiik, Qingwen Wu, Doosoo Yoon, André Young, Ken Young, Ziri Younsi, Feng Yuan, Ye-Fei Yuan, J. Anton Zensus, Guang-Yao Zhao, Shan-Shan Zhao +237 moredoaj +1 more sourceDesign and Engineering of an Artificial Bifunctional N‐Deacetylase/N‐Sulfotransferase for the Biosynthesis of N‐Sulfated Heparosan
Advanced Science, EarlyView.An artificial bifunctional N‐deacetylase/N‐sulfotransferase was engineered in Escherichia coli by combining screened N‐deacetylases with an NST domain. The integrated engineering strategy improved enzyme performance. The optimized enzyme efficiently converted heparosan into N‐sulfated heparosan, addressing a key bottleneck in microbial heparin ...Xintong Xi, Ruirui Xu, Daoan Wang, Guobin Yin, Xinjing Wang, Haiqin Chen, Guocheng Du, Jian Chen, Zhen Kang +8 morewiley +1 more sourceSelective Dynamical Imaging of Interferometric Data
The Astrophysical Journal Letters, 2022 Recent developments in very long baseline interferometry (VLBI) have made it possible for the Event Horizon Telescope (EHT) to resolve the innermost accretion flows of the largest supermassive black holes on the sky.Joseph Farah, Peter Galison, Kazunori Akiyama, Katherine L. Bouman, Geoffrey C. Bower, Andrew Chael, Antonio Fuentes, José L. Gómez, Mareki Honma, Michael D. Johnson, Yutaro Kofuji, Daniel P. Marrone, Kotaro Moriyama, Ramesh Narayan, Dominic W. Pesce, Paul Tiede, Maciek Wielgus, Guang-Yao Zhao, The Event Horizon Telescope Collaboration, Antxon Alberdi, Walter Alef, Juan Carlos Algaba, Richard Anantua, Keiichi Asada, Rebecca Azulay, Anne-Kathrin Baczko, David Ball, Mislav Baloković, John Barrett, Bradford A. Benson, Dan Bintley, Lindy Blackburn, Raymond Blundell, Wilfred Boland, Hope Boyce, Michael Bremer, Christiaan D. Brinkerink, Roger Brissenden, Silke Britzen, Avery E. Broderick, Dominique Broguiere, Thomas Bronzwaer, Sandra Bustamente, Do-Young Byun, John E. Carlstrom, Chi-kwan Chan, Koushik Chatterjee, Shami Chatterjee, Ming-Tang Chen, Yongjun Chen, Ilje Cho, Pierre Christian, John E. Conway, James M. Cordes, Thomas M. Crawford, Geoffrey B. Crew, Alejandro Cruz-Osorio, Yuzhu Cui, Jordy Davelaar, Mariafelicia De Laurentis, Roger Deane, Jessica Dempsey, Gregory Desvignes, Sheperd S. Doeleman, Ralph P. Eatough, Heino Falcke, Vincent L. Fish, Ed Fomalont, H. Alyson Ford, Raquel Fraga-Encinas, Per Friberg, Christian M. Fromm, Charles F. Gammie, Roberto Garc’a, Olivier Gentaz, Ciriaco Goddi, Roman Gold, Arturo I. Gómez-Ruiz, Minfeng Gu, Mark Gurwell, Kazuhiro Hada, Daryl Haggard, Michael H. Hecht, Ronald Hesper, Luis C. Ho, Paul Ho, Chih-Wei L. Huang, Lei Huang, David H. Hughes, Shiro Ikeda, Makoto Inoue, Sara Issaoun, David J. James, Buell T. Jannuzi, Michael Janssen, Britton Jeter, Wu Jiang, Alejandra Jimenez-Rosales, Svetlana Jorstad, Taehyun Jung, Mansour Karami, Ramesh Karuppusamy, Tomohisa Kawashima, Garrett K. Keating, Mark Kettenis, Dong-Jin Kim, Jae-Young Kim, Jongsoo Kim, Junhan Kim, Motoki Kino, Jun Yi Koay, Patrick M. Koch, Shoko Koyama, Carsten Kramer, Michael Kramer, Thomas P. Krichbaum, Cheng-Yu Kuo, Tod R. Lauer, Sang-Sung Lee, Aviad Levis, Yan-Rong Li, Zhiyuan Li, Rocco Lico, Greg Lindahl, Michael Lindqvist, Jun Liu, Kuo Liu, Elisabetta Liuzzo, Wen-Ping Lo, Andrei P. Lobanov, Laurent Loinard, Colin Lonsdale, Ru-Sen Lu, Nicholas R. MacDonald, Jirong Mao, Nicola Marchili, Sera Markoff, Alan P. Marscher, Iván Martí-Vidal, Satoki Matsushita, Lynn D. Matthews, Lia Medeiros, Karl M. Menten, Izumi Mizuno, Yosuke Mizuno, James M. Moran, Monika Moscibrodzka, Cornelia Müller, Alejandro Mus Mejas, Gibwa Musoke, Hiroshi Nagai, Neil M. Nagar, Masanori Nakamura, Gopal Narayanan, Iniyan Natarajan, Antonios Nathanail, Joey Neilsen, Roberto Neri, Chunchong Ni, Aristeidis Noutsos, Michael A. Nowak, Hiroki Okino, Héctor Olivares, Gisela N. Ortiz-León, Tomoaki Oyama, Feryal zel, Daniel C. M. Palumbo, Jongho Park, Nimesh Patel, Ue-Li Pen, Vincent Piétu, Richard Plambeck, Aleksandar PopStefanija, Oliver Porth, Felix M. Pötzl, Ben Prather, Jorge A. Preciado-López, Dimitrios Psaltis, Hung-Yi Pu, Venkatessh Ramakrishnan, Ramprasad Rao, Mark G. Rawlings, Alexander W. Raymond, Luciano Rezzolla, Bart Ripperda, Freek Roelofs, Alan Rogers, Eduardo Ros, Mel Rose, Arash Roshanineshat, Helge Rottmann, Alan L. Roy, Chet Ruszczyk, Kazi L. J. Rygl, Salvador Sánchez, David Sánchez-Arguelles, Mahito Sasada, Tuomas Savolainen, F. Peter Schloerb, Karl-Friedrich Schuster, Lijing Shao, Zhiqiang Shen, Des Small, Bong Won Sohn, Jason SooHoo, He Sun, Fumie Tazaki, Alexandra J. Tetarenko, Remo P. J. Tilanus, Michael Titus, Kenji Toma, Pablo Torne, Efthalia Traianou, Tyler Trent, Sascha Trippe, Ilse van Bemmel, Huib Jan van Langevelde, Daniel R. van Rossum, Jan Wagner, Derek Ward-Thompson, John Wardle, Jonathan Weintroub, Norbert Wex, Robert Wharton, Kaj Wiik, George N. Wong, Qingwen Wu, Doosoo Yoon, André Young, Ken Young, Ziri Younsi, Feng Yuan, Ye-Fei Yuan, J. Anton Zensus, Shan-Shan Zhao +234 moredoaj +1 more sourceCancer‐Associated BCL‐2 Mutants Reveal Mechanisms Towards Venetoclax Resistance
Advanced Science, EarlyView.Venetoclax (VEN) resistance in chronic lymphocytic leukemia arises from diverse BCL2 mutations. We map mechanisms contributing to VEN resistance across common BCL‐2 variants. G101V and D103Y reduce drug binding and increase sequestration of pro‐apoptotic proteins. V156D blocks VEN allosterically.Jonas Aufdermauer, Ian de Ridder, Mahjoobeh Ehsani, Marasim Khan, Justin Kale, Lukas P. Frenzel, David Andrews, Spyridoula Karamanou, Ana J. Garcia‐Saez, Geert Bultynck +9 morewiley +1 more sourceEngineered Brain‐Targeted Exosomes Delivering FGF1 for Sustained Glycemic Regulation and Multitarget Neurovascular Protection in Diabetic Stroke
Advanced Science, EarlyView.ABSTRACT
Diabetic stroke is characterized by a hyperglycemic and pro‐inflammatory microenvironment that exacerbates neurovascular dysfunction. However, the blood–brain barrier (BBB) remains a formidable obstacle, restricting the delivery of most therapeutic molecules.Bixin Shen, Chengxiang Zhang, Junhui Wang, Xichong Zhong, Shihao Chen, Xue Wang, Xiaokun Li, Li Lin +7 morewiley +1 more sourceINTELLECTUAL PROPERTY AND PERFORMANCE: A BIBLIOMETRIC ANALYSIS
Revista INGI, 2019 Este trabalho objetivou identificar e quantificar a produção acadêmica mundial dos últimos cinco anos acerca da propriedade intelectual, da inovação e/ou da intangibilidade e seus impactos sobre o desempenho ou valor econômico-financeiro de empresas ...Marina Bezerra da Silva, Maria da Conceição Nascimento Dias de Sousa, Maria Emília Camargo, Mariane Camargo Priesnitz, Suzana Leitão Russo +4 moredoaj RNA Promotes Synapsin Condensates That Organize Synaptic Vesicles in Live Neurons and Enable Localized Translation in Reconstituted System
Advanced Science, EarlyView.Condensates at synapses organize synaptic vesicles (SVs) and are crucial for efficient neurotransmitter release, yet how RNA contributes to this mesoscale architecture remains poorly understood. Here we uncover that RNA modulates synapsin–driven condensates.Branislava Rankovic, Zachary M. Geisterfer, Akshita Chhabra, Vladimir M. Jovanovic, Ian Seim, Christian Hoffmann, Antonela Condric, Gerard Aguilar Pérez, Rinse de Boer, Lars T. Hofstede, Jingao Sun, Kiara Freitag, Katja Nowick, Marina Jendrach, Frank L. Heppner, Vladimir Despic, Michaela Müller‐McNicoll, Stephan Sigrist, Geert van den Bogaart, Sofiia Reshetniak, Amy S. Gladfelter, Dragomir Milovanovic +21 morewiley +1 more sourceBrasil. Lei n. 12.470, de 31 de agosto de 2011
, 2011 Altera os arts. 21 e 24 da Lei n. 8212, de 24 de julho de 1991, que dispõe sobre o Plano de Custeio da Previdência Social, para estabelecer alíquota diferenciada de contribuição para o microempreendedor individual e do segurado facultativo sem renda ...Brasilcore
