Leigh disease - Open Access .click

Results 161 to 170 of about 12,985,405 (284)

NDUFS7 variant in dogs with Leigh syndrome and its functional validation in a Drosophila melanogaster model

Scientific Reports
Two Jack-Russell Terrier × Chihuahua mixed-breed littermates with Leigh syndrome were investigated. The dogs presented with progressive ataxia, dystonia, and increased lactate levels.
Matthias Christen +9 more
doaj +1 more source

Vulnerability of marine megafauna to global at‐sea anthropogenic threats

Conservation Biology, Volume 40, Issue 1, February 2026.
Abstract Marine megafauna species are affected by a wide range of anthropogenic threats. To evaluate the risk of such threats, species’ vulnerability to each threat must first be determined. We build on the existing threats classification scheme and ranking system of the International Union for Conservation of Nature (IUCN) Red List of Threatened ...
Michelle VanCompernolle +309 more
wiley +1 more source

Reflections on the Connections Between Work and Health [PDF]

, 2000
Describes approaches that TCWF is using to improve health through employment-related strategies, and identifies some of the challenges the foundation has experienced in the cross-disciplinary endeavor.
Irene Yen, Ruth Tebbets Brousseau
core

Social Frailty in Heart Failure: Concept, Impact and Preventive Strategies

Journal of Advanced Nursing, Volume 82, Issue 2, Page 1819-1826, February 2026.
ABSTRACT Aims To explore the conceptualisation of social frailty and discuss its role in shaping the disease trajectory of heart failure. Based on the discussion, recommendations on how to prevent and manage social frailty in this clinical cohort are delineated. Design A discursive paper.
Miao Miao +2 more
wiley +1 more source

Immunohistochemical Analysis of Tom20 in Choroid Plexus Epithelial Cells From Elderly Brains With Neurodegenerative Diseases

Neuropathology, Volume 46, Issue 1, February 2026.
ABSTRACT The choroid plexus (CP) contributes to cerebrospinal fluid (CSF) production and regulation of circadian rhythm. Recently, many neuroimaging studies have reported enlarged CP volumes in patients with neurodegenerative diseases, including Alzheimer's disease (AD).
Ryuta Murakami +8 more
wiley +1 more source

Site‐Specific Mitochondrial RNA N1‐Methyladenosine Demethylation via an Engineered MTS‐PUF‐ALKBH3 Fusion Protein

Advanced Science, Volume 13, Issue 1, 5 January 2026.
A CRISPR‐free mitochondrial RNA m1A demethylation (MRD) editor combining MTS, PUF proteins, and ALKBH3 enables precise m1A removal from mitochondrial mRNA and tRNA, which influences mitochondrial protein levels, cellular proliferation, ATP production, and mitochondrial respiration. Subsequently, in vivo demethylation of the m1A modification is achieved
Xiangrui Li +13 more
wiley +1 more source

Complex Metabolomic Changes in a Combined Defect of Glycosylation and Oxidative Phosphorylation in a Patient with Pathogenic Variants in PGM1 and NDUFA13

Cells
Inherited metabolic disorders (IMDs) are genetic disorders that occur in as many as 1:2500 births worldwide. Nevertheless, they are quite rare individually and even more rare is the co-occurrence of two IMDs in one individual.
Silvia Radenkovic +8 more
doaj +1 more source

Does Education Reduce Blood Pressure? Estimating the Biomarker Effect of Compulsory Schooling in England [PDF]

This paper is the first of its kind to estimate the exogenous effect of schooling on reduced blood pressure and the incidence of hypertension. Using the changes of the minimum school-leaving age in the United Kingdom from age 14 to 15 in 1947, and from ...
Nattavudh Powdthavee
core

To be or Not to be Hybrids? A Case‐Study in an Allochthonous Population Involving Illegal Introductions of the Endangered Golden‐Headed and Golden Lion Tamarins

American Journal of Primatology, Volume 88, Issue 1, January 2026.
Genetic analyses of an allochthonous population of Leontopithecus, illegally introduced into an area of the Brazilian Atlantic Forest in Rio de Janeiro, did not detect signs of hybridization. This data provides crucial information to support conservation efforts and prevent new threats to the endangered lion tamarins. ABSTRACT Allochthonous species can
Gabriela Aliaga‐Samanez +11 more
wiley +1 more source

The microbiota–gut–brain axis in mild cognitive impairment and Alzheimer's disease: a scoping review of human studies

Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.
Abstract Alzheimer's disease (AD) is projected to become the highest‐burden neurological disorder globally. Mounting evidence implicates the gut microbiome in AD pathogenesis. This scoping review of gut microbiomes in mild cognitive impairment (MCI) and AD included dietary and probiotic interventions.
Alison Warren +10 more
wiley +1 more source

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