Results 1 to 10 of about 5,164,021 (213)

Oral delivery of carrier-free dual-drug nanocrystal self-assembled microspheres improved NAD+ bioavailability and attenuated cardiac ischemia/reperfusion injury in mice

Drug Delivery, 2021
Nicotinamide riboside (NR), as a dietary supplement, can be converted to nicotinamide adenine dinucleotide (NAD+) in cells to support mitochondrial energy metabolism.
Hongfei Nie, Yarong Zhang, Haiyang Yu, Hong Xiao, Tao Li, Qian Yang   +5 more
doaj   +1 more source

Metabolic network analysis of pre-ASD newborns and 5-year-old children with autism spectrum disorder

Communications Biology
Classical metabolomic and new metabolic network methods were used to study the developmental features of autism spectrum disorder (ASD) in newborns (n = 205) and 5-year-old children (n = 53). Eighty percent of the metabolic impact in ASD was caused by 14
Sai Sachin Lingampelly, Jane C. Naviaux, Luke S. Heuer, Jonathan M. Monk, Kefeng Li, Lin Wang, Lori Haapanen, Chelsea A. Kelland, Judy Van de Water, Robert K. Naviaux   +9 more
doaj   +1 more source

Adult-onset Sandhoff disease presenting with a motor neuron disease phenotype: clinical and mechanistic insights from patient-derived models

Acta Neuropathologica Communications
Sandhoff disease (SD) is a subtype of GM2 gangliosidosis caused by pathogenic variants in Hexosaminidase B (HEXB). It most frequently presents in infancy or early childhood, whereas adult-onset disease is rare and remains incompletely characterized. Here,
Yao Tang, Didi Shan, Hongxu Wang, Xinbo Ji, Yichang Jiao, Jianing Li, Zexin Zhan, Shuangwu Liu, Xiaohan Sun, Pengfei Lin, Jingwen Xu, Dongdong Wang, Xiulian Sun, Chuanzhu Yan, Yuying Zhao, Fuchen Liu   +15 more
doaj   +1 more source

Incomplete Healing as a Cause of Aging: The Role of Mitochondria and the Cell Danger Response

Biology, 2019
The rate of biological aging varies cyclically and episodically in response to changing environmental conditions and the developmentally-controlled biological systems that sense and respond to those changes.
Robert K. Naviaux
doaj   +1 more source

Primary mitochondrial disease in the US: Data from patients and physicians' perspective on health care delivery

Data in Brief, 2019
This article presents data that examine the patient's perception of health care delivery for mitochondrial disease in the US. It also presents the opinions of mitochondrial disease expert physicians about creating a specialised network of clinics to ...
Amel Karaa, Amy Goldstein, Cristy Balcells, Kira Mann, Laura Stanley, Philip E. Yeske, Sumit Parikh   +6 more
doaj   +1 more source

A Recombinant Antibody Against Human DRP1 Serine 616 Phosphorylation Enables Detection of BRAF^V600E-Associated Mitochondrial Division in Cancer

Antibodies
Background/Objectives: Mitochondria are dynamic organelles that continuously undergo balanced cycles of fusion and division to maintain optimal function.
Shanon T. Nizard, Yiyang Chen, Madhavika N. Serasinghe, Ruben Fernandez-Rodriguez, Kamrin D. Shultz, Jesminara Khatun, Anthony Mendoza, Jesse D. Gelles, Juan F. Henao-Martinez, Ioana Abraham-Enachescu, Md Abdullah Al Noman, Stella G. Bayiokos, J. Andrew Duty, Shane Meehan, Mihaela Skobe, Jerry Edward Chipuk   +15 more
doaj   +1 more source

Variable effects of omaveloxolone (RTA408) on primary fibroblasts with mitochondrial defects

Frontiers in Molecular Biosciences, 2022
Omaveloxolone (RTA408) is a second-generation oleanane triterpenoid Nrf2 inducer with antioxidant and anti-inflammatory properties and was reported to improve mitochondrial bioenergetics.
Madleen Zighan, David Arkadir, David Arkadir, Liza Douiev, Liza Douiev, Guy Keller, Guy Keller, Guy Keller, Chaya Miller, Ann Saada, Ann Saada   +10 more
doaj   +1 more source

A gated hydrophobic funnel within BAX binds bioactive lipids to potentiate pro-apoptotic function

Nature Communications
Mitochondria maintain a distinct biochemical environment that cooperates with pro-apoptotic BAX and BH3‑only proteins (e.g., BIM) to promote mitochondrial outer membrane permeabilization (MOMP), the key event to initiate physiological and pharmacological
Jesse D. Gelles, Yiyang Chen, Mark P. A. Luna-Vargas, Ariele Viacava Follis, Md Abdullah Al Noman, Md Kabir, Stella G. Bayiokos, Jarvier N. Mohammed, Tara M. Sebastian, Ngoc Dung Pham, Yi Shi, Jian Jin, Richard W. Kriwacki, Jerry Edward Chipuk   +13 more
doaj   +1 more source

The combined effects of physical exercise training and detraining on adiponectin in overweight and obese children

Integrative Medicine Research, 2013
Background: The purpose of this study is to assess the combined exercise programs (12 weeks' physical exercise training, resistance and aerobic) and 6 weeks' detraining on the correlation of metabolic syndrome (MS) markers and plasma adiponectin level in
Jae-Young Jeon, Jin Han, Hyun-Jun Kim, Moon Soo Park, Dae Yun Seo, Yi-Sub Kwak   +5 more
doaj   +1 more source

Energy metabolism and whole-exome sequencing-based analysis of Sasang constitution: a pilot study

Integrative Medicine Research, 2017
Background: Traditional Korean Sasang constitutional (SC) medicine categorizes individuals into four constitutional types [Tae-eum (TE), So-eum (SE), Tae-yang (TY), or So-yang (SY)] based on biological and physiological characteristics.
Hyoung Kyu Kim, Heetak Lee, Ji Ho So, Seung Hun Jeong, Dae Yun Seo, Jong-Yeol Kim, Sanguk Kim, Jin Han   +7 more
doaj   +1 more source