Results 31 to 40 of about 5,164,021 (213)

A direct interaction between mitochondrial proteins and amyloid-β peptide and its significance for the development and treatment of Alzheimer’s disease [PDF]

, 2015
This work was supported by the Ministry of Education, Youth and Sports CZ (no. LD14009, no. SV/FVZ201201, no. SVV260062), COST CM1103, MH CZ - DRO (UHHK, 00179906), The Alzheimer’s Society, The Barcopel Foundation and the MSD Scottish Life Sciences fund ...
Gunn-Moore, Frank J, Musilek, Kamil, Benek, Ondrej, Kuca, Kamil, Aitken, Laura, Hroch, Lukas   +5 more
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Gene expression in a drosophila model of mitochondrial disease [PDF]

, 2010
Background A point mutation in the Drosophila gene technical knockout (tko), encoding mitoribosomal protein S12, was previously shown to cause a phenotype of respiratory chain deficiency, developmental delay, and neurological abnormalities similar to ...
Esko Kemppainen, Jacobs, H.T., Daniel J M Fernández-Ayala, Shanjun Chen, Fernandez-Ayala, Daniel JM, Kemppainen, E., Kevin M C O'Dell, O'Dell, Kevin MC, Jacobs, Howard T, Chen, S., Chen, Shanjun, Kemppainen, Esko, O'Dell, K.M.C., Kevin M. C. O'Dell, Howard T. Jacobs, Fernández-Ayala, D.J.M., Howard T Jacobs, Daniel J. M. Fernández-Ayala   +17 more
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Anesthetic considerations of Joubert syndrome in patients with mitochondrial disease - A case report - [PDF]

Anesthesia and Pain Medicine, 2021
Background Joubert syndrome and mitochondrial disease are rare congenital diseases in which a wide range of symptoms affects multiple organs. Patients with these diseases present characteristic symptoms related to the musculoskeletal, respiratory, and ...
Jeong Yeon Kim, Koun Jeong, Ki Seob Han, Ji Eun Park, Mun Gyu Kim, Mi Roung Jun   +5 more
doaj   +1 more source

Mitochondria and quality control defects in a mouse model of Gaucher Disease-links to Parkinson's Disease [PDF]

, 2013
Mutations in the glucocerebrosidase (gba) gene cause Gaucher disease (GD), the most common lysosomal storage disorder, and increase susceptibility to Parkinson's disease (PD).
Duchen, Michael R., Gegg, ME, Osellame, LD, Gegg, Matthew E., Osellame, Laura D., Richard-Londt, A, Hargreaves, Iain P., Brandner, Sebastian, Brandner, S, Richard-Londt, Angela, Waddington, Simon N., Hargreaves, IP, Waddington, SN, Schapira, AHV, Rahim, AA, Rahim, Ahad A., Duchen, MR, Schapira, AH, Schapira, Anthony H.V.   +18 more
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Echinochrome A Protects Mitochondrial Function in Cardiomyocytes against Cardiotoxic Drugs

Marine Drugs, 2014
Echinochrome A (Ech A) is a naphthoquinoid pigment from sea urchins that possesses antioxidant, antimicrobial, anti-inflammatory and chelating abilities.
Seung Hun Jeong, Hyoung Kyu Kim, In-Sung Song, Seon Joong Lee, Kyung Soo Ko, Byoung Doo Rhee, Nari Kim, Natalia P. Mishchenko, Sergey A. Fedoryev, Valentin A. Stonik, Jin Han   +10 more
doaj   +1 more source

E3 ligase activity of Carboxyl terminus of Hsc70 interacting protein (CHIP) in Wharton's jelly derived mesenchymal stem cells improves their persistence under hyperglycemic stress and promotes the prophylactic effects against diabetic cardiac damages

Bioengineering & Translational Medicine, 2021
Recent studies indicate that umbilical cord stem cells are cytoprotective against several disorders. One critical limitation in using stem cells is reduction in their viability under stressful conditions, such as diabetes.
Ayaz Ali, Wei‐Wen Kuo, Chia‐Hua Kuo, Jeng‐Fan Lo, Michael Y. C. Chen, Jayasimha R. Daddam, Tsung‐Jung Ho, Vijaya Padma Viswanadha, Marthandam Asokan Shibu, Chih‐Yang Huang   +9 more
doaj   +1 more source

Ubiquitin-proteasome dependent mitochondrial protein quality control [PDF]

, 2014
Dysfunctional mitochondria cause many neurodegenerative disorders and with aging in general, mechanisms of mitochondrial quality control are essential for cellular function.
Benischke, Anne-Sophie
core   +1 more source

Acetylcholinesterase Inhibitory Activity of Pigment Echinochrome A from Sea Urchin Scaphechinus mirabilis

Marine Drugs, 2014
Echinochrome A (EchA) is a dark-red pigment of the polyhydroxynaphthoquinone class isolated from sea urchin Scaphechinus mirabilis. Acetylcholinesterase (AChE) inhibitors are used in the treatment of various neuromuscular disorders, and are considered as
Sung Ryul Lee, Julius Ryan D. Pronto, Bolor-Erdene Sarankhuu, Kyung Soo Ko, Byoung Doo Rhee, Nari Kim, Natalia P. Mishchenko, Sergey A. Fedoreyev, Valentin A. Stonik, Jin Han   +9 more
doaj   +1 more source

The Mitochondrial Chaperone Protein TRAP1 Mitigates α-Synuclein Toxicity [PDF]

, 2012
Overexpression or mutation of alpha-Synuclein is associated with protein aggregation and interferes with a number of cellular processes, including mitochondrial integrity and function.
Butler, Erin K., Jane P Toegel, Jane P. Toegel (185544), Winklhofer Konstanze F., A Kathrin Lutz, Voigt Aaron, Falkenburger, Bjoern, Toegel Jane P., Konstanze F. Winklhofer (185550), Gerhardt, Ellen, Karsten Peter, A. Kathrin Lutz (185542), Voigt, Aaron, Butler Erin K., Toegel, Jane P., Peter Karsten (123433), Björn Falkenburger (185548), Schulz, Joerg B., Falkenburger, Bjoern H., Peter Karsten, Ellen Gerhardt (185546), Andrea Reinartz (185549), Reinartz, Andrea, Erin K Butler, Ellen Gerhardt, Lutz A. Kathrin, Jörg B Schulz, Gerhardt Ellen, Aaron Voigt (123446), Reinartz Andrea, Jörg B. Schulz (123442), Lutz, A. Kathrin, Karsten, Peter, Konstanze F Winklhofer, Aaron Voigt, Björn Falkenburger, Schulz Jörg B., Erin K. Butler (185540), Winklhofer, Konstanze F., Falkenburger Björn, Andrea Reinartz, Toegel, Jane Patricia   +41 more
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Echinochrome A Increases Mitochondrial Mass and Function by Modulating Mitochondrial Biogenesis Regulatory Genes

Marine Drugs, 2014
Echinochrome A (Ech A) is a natural pigment from sea urchins that has been reported to have antioxidant properties and a cardio protective effect against ischemia reperfusion injury.
Seung Hun Jeong, Hyoung Kyu Kim, In-Sung Song, Su Jin Noh, Jubert Marquez, Kyung Soo Ko, Byoung Doo Rhee, Nari Kim, Natalia P. Mishchenko, Sergey A. Fedoreyev, Valentin A. Stonik, Jin Han   +11 more
doaj   +1 more source