Results 21 to 30 of about 5,164,021 (213)

Rescue of Heart Failure by Mitochondrial Recovery [PDF]

International Neurourology Journal, 2016
Heart failure (HF) is a multifactorial disease brought about by numerous, and oftentimes complex, etiological mechanisms. Although well studied, HF continues to affect millions of people worldwide and current treatments can only prevent further ...
Jubert Marquez, Sung Ryul Lee, Nari Kim, Jin Han   +3 more
doaj   +1 more source

Mapping gene associations in human mitochondria using clinical disease phenotypes [PDF]

, 2009
Nuclear genes encode most mitochondrial proteins, and their mutations cause diverse and debilitating clinical disorders. To date, 1,200 of these mitochondrial genes have been recorded, while no standardized catalog exists of the associated clinical ...
Curt Scharfe, Allen, Edward A., Enns, Gregory M., Guan-Cheng Li, Henry Horng-Shing Lu, Lu, Henry Horng-Shing, Neuenburg, Jutta K., Ronald W. Davis, Jutta K Neuenburg, Tina M. Cowan, Cowan, Tina M., Thomas Klopstock, Jutta K. Neuenburg, Klopstock, Thomas, Tina M Cowan, Scharfe, Curt, Li, Guan-Cheng, Edward A Allen, Ronald W Davis, Edward A. Allen, Davis, Ronald W., Gregory M Enns, Gregory M. Enns   +22 more
core   +1 more source

Exercise and Neuroinflammation in Health and Disease [PDF]

International Neurourology Journal, 2019
Neuroinflammation is a central pathological feature of several acute and chronic brain diseases, including Alzheimer disease (AD), Parkinson disease (PD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS).
Dae-Yun Seo, Jun-Won Heo, Jeong Rim Ko, Hyo-Bum Kwak   +3 more
doaj   +1 more source

Neurodegenerative stress related mitochondrial proteostasis [PDF]

, 2015
1.1 Background: Mitochondria are the main site of energy production in most cells. Furthermore, they are involved in a multitude of other essential cellular processes, such as regulating the cellular calcium pool, lipid metabolism and programmed cell ...
Fang, Lei
core   +1 more source

Signal transducer and activator of transcription 2 deficiency is a novel disorder of mitochondrial fission [PDF]

, 2015
Defects of mitochondrial dynamics are emerging causes of neurological disease. In two children presenting with severe neurological deterioration following viral infection we identified a novel homozygous STAT2 mutation, c.1836C4A (p.Cys612Ter), using ...
Jan-Willem Taanman, Shamima Rahman, Laura D. Osellame, Gilmour, Kimberley, Glenn Anderson, Jacques, Thomas S, Sophie Hambleton, Cale, Catherine, Osellame, Laura, Plagnol, Vincent, Chalasani, A, Annapurna Chalasani, Gilmour, KC, Hambleton, Sophie, Wedatilake, Yehani, Gilmour, Kimberley C, Duchen, Michael R, Osellame, LD, Taanman, Jan-Willem, Jacques, S, Vincent Plagnol, Plagnol, V, Rahman, S, Yehani Wedatilake, Michael R. Duchen, Shahni, Rojeen, Qasim, Waseem, Thomas S. Jacques, Catherine M. Cale, Duchen, Michael, Cale, Catherine M, Waseem Qasim, Anderson, Glenn, Wadatilake, Y, Cale, CM, Rahman, Shamima, Osellame, Laura D, Taanman, JW, Chan, E, Jacques, Thomas, Anderson, G, Rojeen Shahni, Chalasani, Annapurna, Kimberly C. Gilmour, Qasim, W, Emma Chan, Hambleton, S, Duchen, MR, Shahni, R, Chan, Emma   +49 more
core   +1 more source

Mechanism of neurodegeneration of neurons with mitochondrial DNA mutations [PDF]

, 2010
Mutations of mitochondrial DNA are associated with a wide spectrum of disorders, primarily affecting the central nervous system and muscle function. The specific consequences of mitochondrial DNA mutations for neuronal pathophysiology are not understood.
Turnbull, Douglass M., Turnbull, Doug, Kirby, Denise M., Abramov, Andrey Y., Duchen, Michael, Abramov, Andrey, Smulders-Srinivasan, Tora, Smulders-Srinivasan, Tora K.; id_orcid, Duchen, Michael R., Acin-Perez, Rebecca, Enriquez, José Antonio, Kirby, Denise, Smulders-Srinivasan, Tora K., Lightowlers, Robert, Acin-Perez, Rebeca, Enriquez, Jose, Lightowlers, Robert N.   +16 more
core   +1 more source

Mitochondria as a Target for Future Diabetes Treatments

International Journal of Medical Students, 2015
Diabetes mellitus is rapidly becoming the world’s most dangerous serial killer. Type 1 diabetes (T1D) is a currently incurable autoimmune disease marked by progressive, and eventually exhaustive, destruction of the insulin-producing pancreatic beta cells.
Franziska Thimm, Marten Szibor
doaj   +3 more sources

Morning and evening exercise

Integrative Medicine Research, 2013
A growing body of evidence suggests that exercise may contribute to preventing pathological changes, treating multiple chronic diseases, and reducing mortality and morbidity ratios.
Dae Yun Seo, SungRyul Lee, Nari Kim, Kyung Soo Ko, Byoung Doo Rhee, Byung Joo Park, Jin Han   +6 more
doaj   +1 more source

Mitochondrial dysfunction in Parkinson's disease : pathogenesis and neuroprotection [PDF]

, 2011
Peer ...
Teismann, Peter, Mounsey, Ross B, Ross B. Mounsey, Peter Teismann   +3 more
core   +1 more source

Pu-18-N-butylimide-NMGA-GNP conjugate is effective against hepatocellular carcinoma

Integrative Medicine Research, 2013
Background: Photodynamic therapy (PDT) is a new modality in the treatment of cancer. This study thus aims to examine whether the PDT is effective against in vivo hepatocellular carcinoma.
Jin-Geun Kwon, In-Sung Song, Min-Soo Kim, Beom Hee Lee, Jung Hwa Kim, Il Yoon, Young Key Shim, Nari Kim, Jin Han, Jae Boum Youm   +9 more
doaj   +1 more source