Echinochrome A Inhibits Melanogenesis in B16F10 Cells by Downregulating CREB Signaling [PDF]
Marine Drugs, 2022 Excessive increase in melanin pigment in the skin can be caused by a variety of environmental factors, including UV radiation, and can result in spots, freckles, and skin cancer.
Mi Ran Choi +11 more
doaj +4 more sources
Echinochrome A Reverses Kidney Abnormality and Reduces Blood Pressure in a Rat Model of Preeclampsia [PDF]
Marine Drugs, 2022 We aimed to observe the effects of Echinochrome A (Ech A) on systemic changes using a rat model of preeclampsia. The results showed that an infusion of angiotensin II (Ang II) through an osmotic pump (1 μg/kg/min) on GD 8 increased systolic and diastolic
Huixing Cui +6 more
doaj +4 more sources
Multiple Effects of Echinochrome A on Selected Ion Channels Implicated in Skin Physiology [PDF]
Marine Drugs, 2023 Echinochrome A (Ech A), a naphthoquinoid pigment from sea urchins, is known to have anti-inflammatory and analgesic effects that have been suggested to be mediated by antioxidant activity and intracellular signaling modulation.
Sung Eun Kim +8 more
doaj +4 more sources
Echinochrome A Prevents Diabetic Nephropathy by Inhibiting the PKC-Iota Pathway and Enhancing Renal Mitochondrial Function in db/db Mice [PDF]
Marine Drugs, 2023 Echinochrome A (EchA) is a natural bioproduct extracted from sea urchins, and is an active component of the clinical drug, Histochrome®. EchA has antioxidant, anti-inflammatory, and antimicrobial effects. However, its effects on diabetic nephropathy (DN)
Trong Kha Pham +11 more
doaj +4 more sources
Equinocromo A en el fluido celómico de Arbacia stellata (Echinodermata: Echinoidea) con interés para la acuicultura [PDF]
AquaTechnica, 2021 Within the framework of the generation of research studies in applied biology for the diversification of aquaculture in Ecuador, the native sea urchin Arbacia stellata was considered with potential for its aquaculture and extraction of macroenergetic ...
Javier José Palma-Chávez +2 more
doaj +3 more sources
Natural Substances vs. Approved Drugs in the Treatment of Main Cardiovascular Disorders-Is There a Breakthrough? [PDF]
Antioxidants (Basel), 2023 Cardiovascular diseases (CVDs) are a group of diseases with a very high rate of morbidity and mortality. The clinical presentation of CVDs can vary from asymptomatic to classic symptoms such as chest pain in patients with myocardial infarction.
Grujić-Milanović J +6 more
europepmc +4 more sources
Multi-omic analysis reveals genes and proteins integral to bioactivity of Echinochrome A isolated from the waste stream of the sea urchin industry in Aotearoa New Zealand. [PDF]
Food Sci NutrThe mechanism of action of Echinochrome A (Ech A) was evaluated using unbiased genomic and proteomic analyses. Growth analyses of gene deletions and measurements of protein abundance identified the importance of 20 genes and 92 proteins. The antioxidant activity of Ech A may begin with alterations in DNA replication, followed by iron chelation and ...
Hammond J +7 more
europepmc +2 more sources
Development of Novel Pharmaceutical Forms of the Marine Bioactive Pigment Echinochrome A Enabling Alternative Routes of Administration [PDF]
Marine Drugs, 2023 Echinochrome A (EchA), a marine bioactive pigment isolated from various sea urchin species, is the active agent of the clinically approved drug Histochrome®.
Stefanos Kikionis +8 more
doaj +2 more sources
Hematopoietic effect of echinochrome on phenylhydrazine-induced hemolytic anemia in rats [PDF]
PeerJ, 2023 Background Hemolytic anemia (HA) is a serious health condition resulting from reduced erythrocytes’ average life span. Echinochrome (Ech) is a dark-red pigment found in shells and spines of sea urchins.
Mona S. E. F. El-Shehry +11 more
doaj +3 more sources
PHNQ from Evechinus chloroticus Sea Urchin Supplemented with Calcium Promotes Mineralization in Saos-2 Human Bone Cell Line [PDF]
Marine Drugs, 2020 Polyhydroxylated naphthoquinones (PHNQs), known as spinochromes that can be extracted from sea urchins, are bioactive compounds reported to have medicinal properties and antioxidant activity.
Yakun Hou +9 more
doaj +2 more sources