Echinochrome A Inhibits Melanogenesis in B16F10 Cells by Downregulating CREB Signaling [PDF]
Marine Drugs, 2022 Excessive increase in melanin pigment in the skin can be caused by a variety of environmental factors, including UV radiation, and can result in spots, freckles, and skin cancer.
Elena Vasileva +2 more
exaly +4 more sources
Regulation of Inflammation-Mediated Endothelial to Mesenchymal Transition with Echinochrome a for Improving Myocardial Dysfunction [PDF]
Marine Drugs, 2022 Endothelial–mesenchymal transition (EndMT) is a process by which endothelial cells (ECs) transition into mesenchymal cells (e.g., myofibroblasts and smooth muscle cells) and induce fibrosis of cells/tissues, due to ischemic conditions in the heart ...
Woochul Chang +2 more
exaly +4 more sources
Echinochrome A Treatment Alleviates Atopic Dermatitis-like Skin Lesions in NC/Nga Mice via IL-4 and IL-13 Suppression [PDF]
Marine Drugs, 2021 Atopic dermatitis (AD) is a chronic inflammatory skin disease in which skin barrier dysfunction leads to dryness, pruritus, and erythematous lesions. AD is triggered by immune imbalance and oxidative stress.
Elena Vasileva +2 more
exaly +4 more sources
Echinochrome A Reverses Kidney Abnormality and Reduces Blood Pressure in a Rat Model of Preeclampsia [PDF]
Marine Drugs, 2022 We aimed to observe the effects of Echinochrome A (Ech A) on systemic changes using a rat model of preeclampsia. The results showed that an infusion of angiotensin II (Ang II) through an osmotic pump (1 μg/kg/min) on GD 8 increased systolic and diastolic
Huixing Cui +6 more
doaj +2 more sources
Multi-omic analysis reveals genes and proteins integral to bioactivity of Echinochrome A isolated from the waste stream of the sea urchin industry in Aotearoa New Zealand. [PDF]
Food Sci NutrThe mechanism of action of Echinochrome A (Ech A) was evaluated using unbiased genomic and proteomic analyses. Growth analyses of gene deletions and measurements of protein abundance identified the importance of 20 genes and 92 proteins. The antioxidant activity of Ech A may begin with alterations in DNA replication, followed by iron chelation and ...
Hammond J +7 more
europepmc +2 more sources
Echinochrome A Treatment Alleviates Fibrosis and Inflammation in Bleomycin-Induced Scleroderma
Marine Drugs, 2021 Scleroderma is an autoimmune disease caused by the abnormal regulation of extracellular matrix synthesis and is activated by non-regulated inflammatory cells and cytokines.
Ki-Tae Ha +2 more
exaly +3 more sources
Echinochrome A Prevents Diabetic Nephropathy by Inhibiting the PKC-Iota Pathway and Enhancing Renal Mitochondrial Function in db/db Mice [PDF]
Marine Drugs, 2023 Echinochrome A (EchA) is a natural bioproduct extracted from sea urchins, and is an active component of the clinical drug, Histochrome®. EchA has antioxidant, anti-inflammatory, and antimicrobial effects. However, its effects on diabetic nephropathy (DN)
Trong Kha Pham +11 more
doaj +2 more sources
Development of Novel Pharmaceutical Forms of the Marine Bioactive Pigment Echinochrome A Enabling Alternative Routes of Administration [PDF]
Marine Drugs, 2023 Echinochrome A (EchA), a marine bioactive pigment isolated from various sea urchin species, is the active agent of the clinically approved drug Histochrome®.
Stefanos Kikionis +8 more
doaj +2 more sources
Hematopoietic effect of echinochrome on phenylhydrazine-induced hemolytic anemia in rats [PDF]
PeerJ, 2023 Background Hemolytic anemia (HA) is a serious health condition resulting from reduced erythrocytes’ average life span. Echinochrome (Ech) is a dark-red pigment found in shells and spines of sea urchins.
Mona S. E. F. El-Shehry +11 more
doaj +3 more sources
Antiviral and Antioxidant Properties of Echinochrome A
Marine Drugs, 2018 The aim of this study was to examine the in vitro antioxidant and antiviral activities of echinochrome A and echinochrome-based antioxidant composition against tick-borne encephalitis virus (TBEV) and herpes simplex virus type 1 (HSV-1).
Galina Leonova +2 more
exaly +3 more sources