Results 1 to 10 of about 17,741,837 (346)

Favipiravir at high doses has potent antiviral activity in SARS-CoV-2−infected hamsters, whereas hydroxychloroquine lacks activity

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance The previous lack of consensus around the use of hydroxychloroquine for COVID-19 patients underlines the need to thoroughly assess the in vivo efficacy of drugs against SARS-CoV-2.
Suzanne J. F. Kaptein, Sofie Jacobs, Lana Langendries, L. Seldeslachts, Sebastiaan ter Horst, L. Liesenborghs, B. Hens, V. Vergote, E. Heylen, Karine Barthélémy, E. Maas, Carolien de Keyzer, Lindsey Bervoets, Jasper Rymenants, T. Van Buyten, Xin Zhang, R. Abdelnabi, J. Pang, Rachel J. Williams, H. Thibaut, K. Dallmeier, R. Boudewijns, Jens Wouters, P. Augustijns, N. Verougstraete, C. Cawthorne, J. Breuer, C. Solas, B. Weynand, P. Annaert, I. Spriet, Greetje Vande Velde, J. Neyts, J. Rocha-Pereira, L. Delang   +34 more
semanticscholar   +1 more source

Antiviral activity of hemocyanins [PDF]

Invertebrate Survival Journal, 2013
Hemocyanins are giant biological macromolecules acting as oxygen-transporting glycoproteins. Most of them are respiratory proteins of arthropods and mollusks, but besides they also exhibit protecting effects against bacterial, fungal and viral invasions.
P Dolashka,, W Voelter
doaj   +2 more sources

Research progress on the antiviral activities of natural products and their derivatives: Structure–activity relationships

Frontiers in Chemistry, 2022
Viruses spread rapidly and are well-adapted to changing environmental events. They can infect the human body readily and trigger fatal diseases. A limited number of drugs are available for specific viral diseases, which can lead to non-efficacy against ...
Yajing Guo, Anna Ma, Xinyan Wang, Chen Yang, Xi Chen, Gen Li, Feng Qiu, Feng Qiu   +7 more
doaj   +1 more source

Camostat mesylate inhibits SARS-CoV-2 activation by TMPRSS2-related proteases and its metabolite GBPA exerts antiviral activity

bioRxiv, 2020
Antiviral therapy is urgently needed to combat the coronavirus disease 2019 (COVID-19) pandemic, which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
M. Hoffmann, Heike Hofmann-Winkler, Joan C. Smith, Nadine Krüger, L. K. Sørensen, O. Søgaard, J. Hasselstrøm, M. Winkler, Tim Hempel, L. Raich, S. Olsson, Takashi Yamazoe, Katsura Yamatsuta, H. Mizuno, S. Ludwig, Frank Noé, J. Sheltzer, M. Kjolby, S. Pöhlmann   +18 more
semanticscholar   +1 more source

Lack of antiviral activity of darunavir against SARS-CoV-2

medRxiv, 2020
Given the high need and the absence of specific antivirals for treatment of COVID-19 (the disease caused by severe acute respiratory syndrome-associated coronavirus-2 [SARS-CoV-2]), human immunodeficiency virus (HIV) protease inhibitors are being ...
S. De Meyer, D. Bojkova, J. Cinatl, E. Van Damme, Christophe Buyck, M. Van Loock, Brian Woodfall, S. Ciesek   +7 more
semanticscholar   +1 more source

Antiviral Activity of CD437 Against Mumps Virus

Frontiers in Microbiology, 2021
Many efforts have been dedicated to the discovery of antiviral drug candidates against the mumps virus (MuV); however, no specific drug has yet been approved.
Fumihiro Kato, Yuichiro Nakatsu, Keiko Murano, Aika Wakata, Toru Kubota, Takayuki Hishiki, Toshiyuki Yamaji, Minoru Kidokoro, Minoru Kidokoro, Hiroshi Katoh, Makoto Takeda   +10 more
doaj   +1 more source

Antiviral activity of green tea and black tea polyphenols in prophylaxis and treatment of COVID-19: A review

Phytomedicine, 2020
Background The rapid spread of novel coronavirus called SARS-CoV-2 or nCoV has caused countries all over the world to impose lockdowns and undertake stringent preventive measures.
S. Mhatre, Tishya Srivastava, S. Naik, V. Patravale   +3 more
semanticscholar   +1 more source

Glycyrrhizic‐Acid‐Based Carbon Dots with High Antiviral Activity by Multisite Inhibition Mechanisms

Small, 2020
With the gradual usage of carbon dots (CDs) in the area of antiviral research, attempts have been stepped up to develop new antiviral CDs with high biocompatibility and antiviral effects.
Ting Tong, Hong-Wei Hu, Junwei Zhou, Shuangfei Deng, Xiaotong Zhang, Wantao Tang, Liurong Fang, Shaobo Xiao, Jian-Gong Liang   +8 more
semanticscholar   +1 more source

Polysaccharides as antiviral agents: antiviral activity of carrageenan [PDF]

Antimicrobial Agents and Chemotherapy, 1987
A number of polysaccharides showed good antiviral activity against several animal viruses. At 5 micrograms/ml, carrageenan prevented the cell monolayer from destruction by herpes simplex virus type 1 (HSV-1) growth. At 10 micrograms/ml, carrageenan reduced the formation of new infectious HSV-1 by almost five logs.
González, M. E., Alarcón, Balbino, Carrasco, Luís   +2 more
openaire   +3 more sources

Antiviral activity of sulfated polysaccharides from marine algae and its application in combating COVID-19: Mini review

Bioresource Technology Reports, 2020
Marine-derived sulfated polysaccharides possess various antiviral activities against a broad range of enveloped and non-enveloped viruses. It has become the potential source of antiviral drugs for pharmaceutical development.
Nidhi Hans, A. Malik, S. Naik
semanticscholar   +1 more source