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Broad-spectrum antiviral activity of ebselen [PDF]
Scientific ReportsBroad-spectrum antivirals are essential for pandemic preparedness, helping reduce mortality and mitigate social disruption. Ebselen, a synthetic organoselenium compound, is under investigation for treating various conditions, including viral infections ...
Kunlakanya Jitobaom +4 more
doaj +2 more sources
The Antiviral Activity of Polyphenols. [PDF]
Mol Nutr Food ResABSTRACT Polyphenols are secondary metabolites produced by a large variety of plants. These compounds that comprise the class of phenolic acids, stilbenes, lignans, coumarins, flavonoids, and tannins have a wide range of employment, from food production to medical usages.
Burkard M +5 more
europepmc +3 more sources
Reactive oxygen species promotion drives auranofin’s antiviral activity against hepatitis E virus [PDF]
Journal of VirologyHepatitis E virus (HEV) causes roughly 20 million yearly global infections and is associated with chronic hepatitis, neurological sequelae, and pregnancy-related adverse outcomes that require antiviral intervention.
Kateland Tiller +5 more
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Phosphorylation of Shiftless by casein kinase 1 δ/ε is required for its antiviral activity [PDF]
Journal of VirologyShiftless (SHFL) is a host antiviral factor that inhibits the viral −1 programmed ribosomal frameshifting (−1PRF). How the antiviral activity of SHFL is regulated is not known. Here, we report that the phosphorylation of SHFL by the casein kinase 1 delta
Yongle Wang +3 more
doaj +2 more sources
Antiviral activity of berberine [PDF]
Archives of Virology, 2020 AbstractPlants are a rich source of new antiviral, pharmacologically active agents. The naturally occurring plant alkaloid berberine (BBR) is one of the phytochemicals with a broad range of biological activity, including anticancer, anti-inflammatory and antiviral activity.
Alicja Warowicka +2 more
openaire +2 more sources
PLoS ONE, 2023 Vitamin D has been shown to have antiviral activity in a number of different systems. However, few studies have investigated whether the antiviral activity is exerted through the vitamin D receptor (VDR).
Janejira Jaratsittisin +4 more
doaj +1 more source
MxA: a broadly acting effector of interferon-induced human innate immunity
Visualized Cancer Medicine, 2022 The Human MxA protein belongs to the dynamin superfamily of large GTPases and plays a vital role in human immunity against a broad spectrum of viruses. Evasion from MxA restriction accounts for the zoonotic transmission of many pathogenic viruses.
Liao Shuang, Gao Song
doaj +1 more source
Antiviral activities of flavonoids
Biomedicine & Pharmacotherapy, 2021 Flavonoids are natural phytochemicals known for their antiviral activity. The flavonoids acts at different stages of viral infection, such as viral entrance, replication and translation of proteins. Viruses cause various diseases such as SARS, Hepatitis, AIDS, Flu, Herpes, etc.
Badshah, Syed Lal +5 more
openaire +3 more sources
Poly(ADP-ribose) potentiates ZAP antiviral activity.
PLoS Pathogens, 2022 Zinc-finger antiviral protein (ZAP), also known as poly(ADP-ribose) polymerase 13 (PARP13), is an antiviral factor that selectively targets viral RNA for degradation.
Guangai Xue +10 more
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Anti–SARS‐CoV‐2 Repurposing Drug Database: Clinical Pharmacology Considerations
CPT: Pharmacometrics & Systems Pharmacology, 2021 A critical step to evaluate the potential in vivo antiviral activity of a drug is to connect the in vivo exposure to its in vitro antiviral activity. The Anti–SARS‐CoV‐2 Repurposing Drug Database is a database that includes both in vitro anti–SARS‐CoV‐2 ...
Xinyuan Zhang +13 more
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