Results 1 to 10 of about 6,413,077 (257)

Antiviral Drug Research Proposal Activity

Journal of Microbiology & Biology Education, 2011
The development of antiviral drugs provides an excellent example of how basic and clinical research must be used together in order to achieve the final goal of treating disease.
Lisa Injaian, Ann C. Smith, Jennifer German Shipley, Gili Marbach-Ad, Brenda Fredericksen   +4 more
doaj   +2 more sources

Broad-spectrum antiviral activity of ebselen [PDF]

Scientific Reports
Broad-spectrum antivirals are essential for pandemic preparedness, helping reduce mortality and mitigate social disruption. Ebselen, a synthetic organoselenium compound, is under investigation for treating various conditions, including viral infections ...
Kunlakanya Jitobaom, Usa Boonyuen, Chompunuch Boonarkart, Thanyaporn Sirihongthong, Prasert Auewarakul   +4 more
doaj   +2 more sources

The vitamin D receptor agonist EB1089 can exert its antiviral activity independently of the vitamin D receptor.

PLoS ONE, 2023
Vitamin D has been shown to have antiviral activity in a number of different systems. However, few studies have investigated whether the antiviral activity is exerted through the vitamin D receptor (VDR).
Janejira Jaratsittisin, Wannapa Sornjai, Thanathom Chailangkarn, Anan Jongkaewwattana, Duncan R Smith   +4 more
doaj   +1 more source

Potential antiviral activity of eleutherine, isoeleutherine, eleuthinone and elecanacine compounds in Eleutherine palmifolia (L.) Merr against NSP3 SARS-COV-2: in silico study [PDF]

, 2023
Eleutherine, isoeleutherine, eleuthinone and elecanacine are secondary metabolites of Dayak onion (Eleutherine palmifolia (L.) Merr) belonging to the naphtoquinone group and considered to have antiviral activity by inhibiting HIV replication.
Nafisa, Belia Bima, Santoso, Sanarto, Mutiah, Roihatul, Rahmah, Zainabur, null Sanarto Santoso, null Roihatul Muti’ah, null Belia Bima Nafisa, null Zainabur Rahmah   +7 more
core   +1 more source

MxA: a broadly acting effector of interferon-induced human innate immunity

Visualized Cancer Medicine, 2022
The Human MxA protein belongs to the dynamin superfamily of large GTPases and plays a vital role in human immunity against a broad spectrum of viruses. Evasion from MxA restriction accounts for the zoonotic transmission of many pathogenic viruses.
Liao Shuang, Gao Song
doaj   +1 more source

Poly(ADP-ribose) potentiates ZAP antiviral activity.

PLoS Pathogens, 2022
Zinc-finger antiviral protein (ZAP), also known as poly(ADP-ribose) polymerase 13 (PARP13), is an antiviral factor that selectively targets viral RNA for degradation.
Guangai Xue, Klaudia Braczyk, Daniel Gonçalves-Carneiro, Daria M Dawidziak, Katarzyna Sanchez, Heley Ong, Yueping Wan, Kaneil K Zadrozny, Barbie K Ganser-Pornillos, Paul D Bieniasz, Owen Pornillos   +10 more
doaj   +1 more source

Anti–SARS‐CoV‐2 Repurposing Drug Database: Clinical Pharmacology Considerations

CPT: Pharmacometrics & Systems Pharmacology, 2021
A critical step to evaluate the potential in vivo antiviral activity of a drug is to connect the in vivo exposure to its in vitro antiviral activity. The Anti–SARS‐CoV‐2 Repurposing Drug Database is a database that includes both in vitro anti–SARS‐CoV‐2 ...
Xinyuan Zhang, Yuching Yang, Manuela Grimstein, Guansheng Liu, Eliford Kitabi, Jianghong Fan, Ying‐Hong Wang, Justin Earp, James L. Weaver, Hao Zhu, Jiang Liu, Kellie S. Reynolds, Shiew‐Mei Huang, Yaning Wang   +13 more
doaj   +1 more source

Antiviral efficacy of nanomaterial-treated textiles in real-life like exposure conditions

Heliyon, 2023
Due to the growing interest towards reducing the number of potentially infectious agents on critical high-touch surfaces, the popularity of antimicrobially and antivirally active surfaces, including textiles, has increased.
Alexandra Nefedova, Kai Rausalu, Eva Zusinaite, Vambola Kisand, Mati Kook, Krisjanis Smits, Alexander Vanetsev, Angela Ivask   +7 more
doaj   +1 more source

Antiviral Activity of Ribosome-Inactivating Proteins

Toxins, 2021
Ribosome-inactivating proteins (RIPs) are rRNA N-glycosylases from plants (EC 3.2.2.22) that inactivate ribosomes thus inhibiting protein synthesis. The antiviral properties of RIPs have been investigated for more than four decades.
Lucía Citores, Rosario Iglesias, José M. Ferreras   +2 more
doaj   +1 more source

Antiviral activity of hemocyanins [PDF]

Invertebrate Survival Journal, 2013
Hemocyanins are giant biological macromolecules acting as oxygen-transporting glycoproteins. Most of them are respiratory proteins of arthropods and mollusks, but besides they also exhibit protecting effects against bacterial, fungal and viral invasions.
P Dolashka,, W Voelter
doaj   +2 more sources