Results 31 to 40 of about 6,413,077 (257)

Advanced virtual screening enables the discovery of a host-targeting and broad-spectrum antiviral agent

, 2023
We employed an advanced virtual screening (AVS) approach to identify potential inhibitors of human dihydroorotate dehydrogenase (DHODH), a validated target for development of broad-spectrum antivirals.
Shavina, Anastasiya, Anastasiya Shavina, Anna Shtro, Daria Danilenko, Erik Arabyan, Zakaryan, Hovakim, Matevosyan, Mher, Harutyunyan, Vardan, Shtro, Anna, Gayane Manukyan, Arabyan, Erik, Mher Matevosyan, Chilingaryan, Garri, Abelyan, Narek, Hietel, Benjamin, Danilenko, Daria, Hovakim Zakaryan, Izmailyan, Roza, Rafayela Grigoryan, Benjamin Hietel, Roza Izmailyan, Hamlet Khachatryan, Vardan Harutyunyan, Khachatryan, Hamlet, Manukyan, Gayane, Narek Abelyan, Grigoryan, Rafayela, Garri Chilingaryan   +27 more
core   +1 more source

Importance of Apolipoprotein A-I and A-II Composition in HDL and Its Potential for Studying COVID-19 and SARS-CoV-2

Medicines, 2021
The composition and properties of apolipoprotein (apo) A-I and apoA-II in high-density lipoproteins (HDL) might be critical to SARS-CoV-2 infection via SR-BI and antiviral activity against COVID-19.
Kyung-Hyun Cho
doaj   +1 more source

Antiviral potential of cathelicidins [PDF]

, 2014
The global burden of morbidity and mortality arising from viral infections is high; however, the development of effective therapeutics has been slow.
Davidson, Donald J, Barlow, Peter G, Gwyer Findlay, Emily, Findlay, Emily Gwyer, Currie, Silke M, Davidson, D.J., Barlow, Peter G., Findlay, E.G., Currie, S.M.   +8 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Antiviral Effects and Mechanisms of Active Ingredients in Tea

Molecules
Viruses play a significant role in human health, as they can cause a wide range of diseases, from mild illnesses to severe and life-threatening conditions.
Xinghai Zhang, Haonan Yu, Panjie Sun, Mengxin Huang, Bo Li   +4 more
doaj   +1 more source

Antiviral Activity of Interferon Alpha-2b and Taurine Combination Against SARS-CoV-2 in vitro

Антибиотики и Химиотерапия, 2022
Interferons (IFN) have antiviral activity against many viruses, including SARS-CoV-2. A combination of IFN-a2b and the antioxidant taurine is widely used in the Russian Federation, and its antiviral activity has not been studied before.
N. P. Kartashova, A. V. Ivanina, E. A. Glubokova, I. N. Falynskova, A. A. Poromov, I. A. Leneva   +5 more
doaj   +1 more source

Comparative analysis of the lambda-interferons IL-28A and IL-29 regarding their transcriptome and their antiviral properties against hepatitis C virus. [PDF]

, 2010
Specific differences in signaling and antiviral properties between the different Lambda-interferons, a novel group of interferons composed of IL-28A, IL-28B and IL-29, are currently unknown.
Ralf Bartenschlager, Brand, Stephan, Burkhard Göke, Göke, Burkhard, Artur Kaul, Stephan Brand, Beigel, Florian, Kaul, Artur, Kathrin Zitzmann, Helmut M. Diepolder, Diegelmann, Julia, Diepolder, Helmut M., Christoph J Auernhammer, Bartenschlager, Ralf, Helmut M Diepolder, Christoph J. Auernhammer, Julia Diegelmann, Florian Beigel, Zitzmann, Kathrin, Auernhammer, Christoph J., Bartenschlager Ralf, Auernhammer Christoph J., Diegelmann Julia, Zitzmann Kathrin, Diepolder Helmut M., Göke Burkhard, Brand Stephan, Kaul Artur, Beigel Florian   +28 more
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Triagem da potencial atividade antiviral de peptídeos antimicrobianos e da hemolinfa de ostras [PDF]

, 2005
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Programa de Pós-Graduação em Biotecnologia.Os produtos naturais constituem uma fonte inesgotável de compostos com atividades farmacológicas promissoras, incluindo ação antiviral.
Gomes, Márcia Cristina Carriel
core  

Antiviral activity of GS-5801 across HBV genotypes.

, 2022
Antiviral activity of GS-5801 across HBV genotypes.
Katherine M. Brendza (158359), Thomas Boesen (57139), Ricardo Ramirez (8153424), Mike Matles (1833883), Li Li (14993), Helen Yu (237158), Tetsuya Kobayashi (556062), Uli Schmitz (158404), Madeleine Willkom (4506652), Gregg Czerwieniec (2101444), Ryan Dick (5566745), Gregory T. Notte (2230342), Chin H. Tay (14232182), Danny Tam (2155843), Tara L. Cheung (14232173), Yili Xu (120717), William E. Delaney IV (12334057), Dwight Barnes (14232176), Marc Labelle (1817047), Eric Paoli (14232179), Chelsea Snyder (3401960), Joy Y. Feng (120703), Todd C. Appleby (3704362), Sarah A. Gilmore (460665), Becket Feierbach (20356), Julie Farand (1843951), Gabriel Birkus (846452)   +26 more
core   +1 more source